Medicinal nicotine for preventing stress induced craving and withdrawal symptoms

药用尼古丁用于预防压力引起的渴望和戒断症状

基本信息

批准号：
8333332
负责人：
MICHAEL KOTLYAR
金额：
$ 18.88万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-15 至 2014-06-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Although most smokers indicate a desire to quit smoking, fewer than 30% achieve long term abstinence using currently available treatments. New treatments for tobacco dependence have been introduced rarely with only two non-nicotine pharmacological aids available. The low smoking cessation success rates and the infrequent introduction of new therapies necessitate that the efficacy of currently available therapies be maximized. Nicotine lozenge is often recommended to be used on an as needed basis with smokers generally told to use the nicotine lozenge when craving or withdrawal symptoms occur. Nicotine concentrations however do not increase substantially until about 10 minutes after nicotine lozenge use and do not peak until approximately 30 minutes after starting use. For subjects experiencing acute symptoms of craving or withdrawal, this delay may be too long to prevent relapse. There are a number of smoking triggers that have been demonstrated in laboratory studies to increase craving and in naturalistic studies to precede smoking lapses. One of the two most commonly cited smoking triggers is the presence of a stressful situation. It is not currently known if use of the nicotine lozenge prior to being exposed to a stressful task attenuates the increase in craving that subjects frequently experience during stress. To address this issue and to identify the time-frame (relative to the stressor) during which a nicotine lozenge should be used, a laboratory study is proposed in which craving and withdrawal symptoms will be measured prior and subsequent to a stress task. Each subject will have one laboratory session at which nicotine lozenge is given immediately after the stressor (to approximate current recommended use of NRT - i.e. after craving and withdrawal symptoms occur) and will be randomized to one laboratory session at which nicotine lozenge will be given either a) immediately prior to; b) 10 minutes; c) 20 minutes; or d) 30 minutes prior to the stressor. Data from this study identifying the optimal time-frame for nicotine lozenge administration will be used in a subsequent grant application to assess if counseling smokers to use nicotine lozenge in anticipation of a smoking trigger results in higher cessation rates than the current practice of counseling smokers to use these products when they need them (i.e. after symptoms of craving or withdrawal have already occurred). Ultimately this line of research should lead to more effective use of medicinal nicotine and higher smoking cessation success rates.

描述（由申请人提供）：尽管大多数吸烟者表明渴望戒烟，但使用当前可用的治疗方法少于30％的长期节制。很少引入有关烟草依赖性的新治疗方法，只有两种非新核碱药理学辅助工具可用。戒烟成功率低和新疗法的不经常引入必须最大化当前可用疗法的功效。通常建议在需要的基础上使用尼古丁lozenge使用，通常被告知吸烟者在渴望或戒断症状时使用尼古丁lozenge。然而，尼古丁浓度直到使用尼古丁lozenge后约10分钟，直到开始使用大约30分钟才达到峰值。对于遇到急性或戒断急性症状的受试者，这种延迟可能太长了，无法防止复发。在实验室研究中，已经证明了许多吸烟触发因素，以增加渴望和自然主义研究，以在吸烟失误之前。两个最常见的吸烟触发因素之一是存在压力状况。目前尚不清楚是否在承受压力大的任务之前是否使用尼古丁lozenge会减轻受试者在压力期间经常经历的渴望的增加。为了解决此问题并确定应使用尼古丁lozenge的时间框架（相对于压力源），提出了一项实验室研究，在该研究中，将在压力任务之前及时测量渴望和戒断症状。每个受试者将在压力源后立即给予一个实验室会议（近似于当前的建议使用NRT-渴望和戒断症状），并将随机分配给一个实验室会话，在该实验室会议上，将在该实验室中，在该实验室会议上，将在该实验室会议上立即给予nicotine lozenge。 b）10分钟； c）20分钟；或d）压力源前30分钟。这项研究的数据确定尼古丁lozenge管理的最佳时间框架将用于随后的赠款申请中，以评估吸烟者是否为吸烟者使用尼古丁洛津格（Thigusing Lozenge）是否会导致吸烟触发触发率，从而比当前的咨询者在需要时使用这些产品的咨询率更高（即，在需要时使用这些产品（即渴望或戒断的症状）。最终，这一研究应导致更有效地利用药用尼古丁和更高的戒烟成功率。