Smoking, Antidepressants and Response to Mental Stress

吸烟、抗抑郁药和精神压力反应

• 批准号: 6922501
• 负责人: MICHAEL KOTLYAR
• 金额: $ 13.36万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6922501
• 关键词: behavioral /social science research tag; blood pressure; cardiovascular disorder; cardiovascular pharmacology; catecholamines; clinical research; heart rate; human subject; human therapy evaluation; mental disorder chemotherapy; paroxetine; patient oriented research; psychological stressor; psychopharmacology; psychosomatic disorders; questionnaires; smoking; tobacco abuse

DESCRIPTION (provided by applicant): This proposal is the second revision of an application originally submitted in February 2003 and resubmitted in November 2003. The goal of the proposed Mentored Patient-Oriented Research Career Development Award is to build upon the previous training and experience of Michael Kotlyar, PharmD, a tenure track assistant professor in Experimental and Clinical Pharmacology and Psychiatry. Via the mentorship, training and research proposed in this application, it is expected that Dr. Kotlyar can develop into an independent, funded investigator. To further develop skills in clinical trial design, biostatistics and ethics, Dr. Kotlyar will enroll in a formal program of study leading to a Master's degree in the Clinical Research Masters Program at the University of Minnesota. Dr. Dorothy Hatsukami, PhD, the director of the Tobacco Use Research Center will serve as Dr. Kotlyar's mentor. The research will assess the effect of paroxetine on the physiological response (blood pressure, heart rate and plasma catecholamine concentrations) and psychological discomfort during laboratory-administered mental stress tasks, administered immediately after smoking a cigarette. The research will be conducted in the NIH funded General Clinical Research Center (GCRC). We hypothesize that relative to placebo; paroxetine will decrease physiological response and reduce perceived psychological discomfort during mental stress tasks. The rationale for this research is that smokers often report smoking in response to stressful situations. Smoking and stress each result physiologically in an increase in sympathetic activity. When smoking is combined with stress, these effects are additive as assessed by measures such as increases in heart rate and blood pressure. Although high reactivity to stress is known to be detrimental to cardiovascular health, there is currently no data assessing the effect of antidepressants on the physiological response to stress in smokers or during the acute smoking period. The training and mentored research project combined with the guidance provided by an interdisciplinary advisory group should well prepare the candidate for a career as an independent, successful patient-oriented researcher.

描述（由申请人提供）： 该提案是对最初于 2003 年 2 月提交并于 2003 年 11 月重新提交的申请的第二次修订。拟议的以患者为导向的研究职业发展奖的目标是建立在药学博士、终身教授 Michael Kotlyar 之前的培训和经验基础上。实验和临床药理学和精神病学助理教授。通过本申请中提出的指导、培训和研究，预计 Kotlyar 博士可以发展成为一名独立的、受资助的研究者。为了进一步发展临床试验设计、生物统计学和伦理学方面的技能，Kotlyar 博士将参加明尼苏达大学临床研究硕士项目的正式学习项目，获得硕士学位。烟草使用研究中心主任 Dorothy Hatsukami 博士将担任 Kotlyar 博士的导师。该研究将评估帕罗西汀对吸烟后立即进行的实验室精神压力任务中的生理反应（血压、心率和血浆儿茶酚胺浓度）和心理不适的影响。该研究将在 NIH 资助的普通临床研究中心（GCRC）进行。我们假设相对于安慰剂而言；帕罗西汀会减少精神压力任务期间的生理反应并减少感知的心理不适。这项研究的基本原理是，吸烟者经常报告吸烟是为了应对压力情况。吸烟和压力都会导致生理上交感神经活动的增加。当吸烟与压力相结合时，通过心率和血压增加等措施评估，这些影响会叠加。尽管已知对压力的高反应性不利于心血管健康，但目前尚无数据评估抗抑郁药对吸烟者或急性吸烟期对压力的生理反应的影响。培训和指导的研究项目与跨学科咨询小组提供的指导相结合，应该为候选人作为独立、成功的以患者为导向的研究人员的职业生涯做好充分准备。