PAROXETINE EFFECTS ON RESPONSE TO MENTAL STRESS IN PATIENTS WITH STABLE ANGINA

帕罗西汀对稳定型心绞痛患者精神压力反应的影响

• 批准号: 7375876
• 负责人: MICHAEL KOTLYAR
• 金额: $ 0.07万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375876
• 关键词: PAROXETINE; EFFECTS; RESPONSE; MENTAL; STRESS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This double-blind crossover placebo controlled crossover study is assessing the effect of 1 month of paroxetine administration on cardiovascular response and psychological discomfort during 2 mental stress tasks in patients with stable angina or a history of angina. After a screening visit, subjects are randomized to receive one month of treatment with either paroxetine (10mg/day for 1 week followed by 20 mg/day) or placebo after which they return to the GCRC for "mental stress testing." Cardiovascular response is measured while subjects perform two tasks expected to result in some mental stress. These tasks consist of giving a short speech and performing a mental arithmetic task. Starting one-half hour prior to mental stress testing and continuing until the conclusion of the visit, blood pressure and heart rate are measured at 1 to 2 minute intervals via an automated blood pressure measuring device. Blood (20 cc's) is drawn immediately prior to mental stress testing (at the end of the relaxation phase) and during each mental stress task. Psychological discomfort during the procedure is assessed after mental stress testing is complete. For the following month, subjects receive the alternate treatment after which "mental stress testing" is repeated.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。这项双盲安慰剂对照跨界研究是评估帕罗西汀给药1个月对稳定心绞痛或心绞痛病史的2个心理压力任务期间的1个月对心血管反应和心理不适的影响。筛查后，受试者被随机接受一个月的帕罗西汀（10mg/天为1周，然后是20 mg/天）或安慰剂，然后他们返回GCRC进行“心理压力测试”。衡量心血管反应，而受试者执行两项预期会导致精神压力的任务。这些任务包括发表简短的演讲和执行精神算术任务。从心理压力测试开始前一半小时开始，然后继续进行访问，通过自动血压测量装置以1至2分钟的间隔测量血压和心率。在进行精神压力测试之前（在放松阶段结束时）和每个精神压力任务之前，立即绘制血液（20 cc）。在完成精神压力测试后，评估手术过程中的心理不适。在接下来的一个月中，受试者会接受替代治疗，然后重复“心理压力测试”。