PAROXETINE EFFECTS ON RESPONSE TO MENTAL STRESS IN PATIENTS WITH STABLE ANGINA

帕罗西汀对稳定型心绞痛患者精神压力反应的影响

• 批准号: 7375876
• 负责人: MICHAEL KOTLYAR
• 金额: $ 0.07万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375876
• 关键词: PAROXETINE; EFFECTS; RESPONSE; MENTAL; STRESS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This double-blind crossover placebo controlled crossover study is assessing the effect of 1 month of paroxetine administration on cardiovascular response and psychological discomfort during 2 mental stress tasks in patients with stable angina or a history of angina. After a screening visit, subjects are randomized to receive one month of treatment with either paroxetine (10mg/day for 1 week followed by 20 mg/day) or placebo after which they return to the GCRC for "mental stress testing." Cardiovascular response is measured while subjects perform two tasks expected to result in some mental stress. These tasks consist of giving a short speech and performing a mental arithmetic task. Starting one-half hour prior to mental stress testing and continuing until the conclusion of the visit, blood pressure and heart rate are measured at 1 to 2 minute intervals via an automated blood pressure measuring device. Blood (20 cc's) is drawn immediately prior to mental stress testing (at the end of the relaxation phase) and during each mental stress task. Psychological discomfort during the procedure is assessed after mental stress testing is complete. For the following month, subjects receive the alternate treatment after which "mental stress testing" is repeated.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。这项双盲交叉安慰剂对照交叉研究正在评估稳定型心绞痛或有心绞痛病史的患者在 2 项精神压力任务期间服用帕罗西汀 1 个月对心血管反应和心理不适的影响。筛选访视后，受试者被随机分配接受一个月的帕罗西汀治疗（10 毫克/天，持续 1 周，随后 20 毫克/天）或安慰剂，之后他们返回 GCRC 进行“精神压力测试”。当受试者执行两项预计会导致一些精神压力的任务时，测量心血管反应。这些任务包括发表简短演讲和执行心算任务。从精神压力测试前一个半小时开始，通过自动血压测量设备每隔 1 至 2 分钟测量一次血压和心率，一直持续到访视结束。在精神压力测试之前（放松阶段结束时）和每次精神压力任务期间抽取血液（20 cc）。精神压力测试完成后，将评估手术过程中的心理不适。在接下来的一个月中，受试者接受替代治疗，然后重复“精神压力测试”。