Noninvasive Evaluation of Pediatric CNS Tumors

儿童中枢神经系统肿瘤的无创评估

• 批准号: 8349452
• 负责人: Katherine e Warren
• 金额: $ 12.47万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8349452
• 关键词: Adult; Angiogenesis Inhibition; Angiogenesis Inhibitors; Antineoplastic Agents; Biological; Biopsy; Brain Neoplasms; Brain Stem Neoplasms; Central Nervous System Neoplasms; Child; Childhood; Childhood Central Nervous System Neoplasm; Cytostatics; Diagnostic radiologic examination; Diffuse; Diffusion; Diffusion Magnetic Resonance Imaging; Discipline of Nuclear Medicine; Disease; Dose; Edema; Evaluation; Failure; Flare; Gadolinium; Glioma; Goals; Gold; Image; Laboratories; Life Expectancy; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Malignant Glioma; Maximum Tolerated Dose; Measurement; Measures; Modality; New Agents; Outcome; Patients; Performance; Perfusion; Phase I Clinical Trials; Phase II Clinical Trials; Physiology; Positron-Emission Tomography; Prognostic Factor; Progression-Free Survivals; Protons; Radiation; Radiation therapy; Radioisotopes; Reaction Time; Research; Safety; Spectrum Analysis; Surrogate Markers; Time; Toxic effect; Vascular Endothelial Growth Factors; Vascular Permeabilities; Work; antitumor agent; bevacizumab; drug efficacy; experience; fluorodeoxyglucose positron emission tomography; gadolinium oxide; imaging modality; neuro-oncology; response; success; tumor; tumor progression; two-dimensional

There are several sections of this project involving different aspects of imaging. 1. MR sequences: We are currently working in the Laboratory of Diagnostic Radiology Research evaluating multiple MR sequences on children with brain tumors, longitudinally, to assess outcome to tehrapy and prognostic factors. These imaging modalities include spectroscopy (single voxel, CSI and multislice multivoxel), perfusion studies (DEMRI, DSC-MRI) and diffusion tenor imaging. 2. Results from NMRS are being compared to the "gold standard" in adult neuro-oncology, i.e. FDG-PET, to determine the correlation between results of each modality. 3. New nuclear medicine studies involving alternate radioisotopes are being evaluated. We have opened a study involving pediatric patients with high grade gliomas or diffuse brainstem tumors who will be evaluated by FLT, FDG and NMRS.The objectives of this study specifically are: Determine the feasibility of 18F-FLT PET imaging in pediatric patients with malignant gliomas Determine the ability of 18F-FLT PET imaging to detect treatment changes in pediatric patients with malignant gliomas undergoing radiation therapy Determine the safety and toxicity profile of PET imaging using 18F-FLT in pediatric patients with malignant gliomas To correlate changes in 18F-FLT PET before and after radiation with outcome (12 month PFS) To compare the performance of 18F-FLT-PET to that of MR perfusion, proton magnetic resonance spectroscopy (1H-MRSI) and 18F-FDG PET in prediction of tumor response, time to progression and overall survival time.

该项目有几个部分涉及成像的不同方面。 1. MR 序列：我们目前正在诊断放射学研究实验室纵向评估脑肿瘤儿童的多个 MR 序列，以评估治疗结果和预后因素。这些成像模式包括光谱学（单体素、CSI 和多层多体素）、灌注研究（DEMRI、DSC-MRI）和弥散期成像。 2. NMRS 的结果与成人神经肿瘤学的“金标准”（即 FDG-PET）进行比较，以确定每种模式结果之间的相关性。 3. 正在评估涉及替代放射性同位素的新核医学研究。我们已经开展了一项研究，涉及患有高级别神经胶质瘤或弥漫性脑干肿瘤的儿科患者，他们将通过 FLT、FDG 和 NMRS 进行评估。这项研究的具体目标是： 确定 18F-FLT PET 成像在患有恶性神经胶质瘤的儿科患者中的可行性确定 18F-FLT PET 成像检测接受放射治疗的恶性神经胶质瘤儿科患者的治疗变化的能力 确定使用 18F-FLT PET 成像的安全性和毒性特征将 18F-FLT PET 的变化与放疗前后的结果（12 个月 PFS）关联起来 将 18F-FLT-PET 的性能与 MR 灌注、质子磁共振波谱 (1H-MRSI) 的性能进行比较18F-FDG PET 预测肿瘤反应、进展时间和总生存时间。