Establishment of an International DIPG Registry

建立国际 DIPG 登记处

• 批准号: 8349530
• 负责人: Katherine e Warren
• 金额: $ 6.23万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8349530
• 关键词: Bioinformatics; Biology; Biopsy; Brain Stem Glioma; Child; Classification; Clinical; Clinical/Radiologic; Collaborations; Data; Databases; Development; Diagnosis; Diffuse; Enrollment; Excision; Glioma; International; Lead; Lesion; Link; Location; Molecular; Operative Surgical Procedures; Pathologic; Patients; Pontine structure; Recruitment Activity; Regimen; Registries; Research Personnel; effective therapy; follow-up; outcome forecast; repository; research study

Diffuse intrinsic pontine gliomas (DIPG) comprise 70-80% of all brainstem gliomas in children. Approximately 300 children develop brainstem gliomas per year. Prognosis for patients with DIPGs remains dismal with a median survival of less than 1 year and no improvement in survival has been realized in more than three decades. No effective chemotherapeutic regimens are currently available.Little is known about the biology of these lesions because they are typically not biopsied and surgical resection is impossible given their location.We are establishing an International Diffuse Intrinsic Pontine Glioma Registry to provide a comprehensive database of clinical, radiologic and pathologic data linked to a bioinformatics repository of molecular data of patients. This is a new project, currently under development. Two initial studies are planned.

弥漫性内在的蓬托神经胶质瘤（DIPG）占儿童所有脑干胶质瘤的70-80％。每年大约有300名儿童患脑干神经胶质瘤。 DIPGS患者的预后仍然令人沮丧，中位存活率少于1年，并且在三十多年来没有实现生存率的改善。目前尚无有效的化学治疗方案。对于这些病变的生物学知识，因为它们通常不是活检，并且鉴于其位置不可能进行手术切除。我们正在建立一个国际弥漫性的固有庞然大兰胶质瘤注册表，以提供临床，放射学和病理学数据链接到Bioectic sorminorics corminitics的临床，放射学和病理学数据的全面数据库。 这是一个新项目，目前正在开发中。计划了两项初步研究。