Noninvasive Evaluation of Pediatric CNS Tumors

儿童中枢神经系统肿瘤的无创评估

• 批准号: 8763439
• 负责人: Katherine e Warren
• 金额: $ 10.27万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8763439
• 关键词: Adult; Angiogenesis Inhibition; Angiogenesis Inhibitors; Antineoplastic Agents; Biological; Biopsy; Brain Neoplasms; Central Nervous System Neoplasms; Child; Childhood Central Nervous System Neoplasm; Cytostatics; Diagnostic radiologic examination; Diffusion; Diffusion Magnetic Resonance Imaging; Discipline of Nuclear Medicine; Disease; Dose; Edema; Evaluation; Failure; Flare; Gadolinium; Goals; Gold; Image; Laboratories; Life Expectancy; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Maximum Tolerated Dose; Measurement; Measures; Modality; New Agents; Outcome; Patients; Perfusion; Phase I Clinical Trials; Phase II Clinical Trials; Physiology; Positron-Emission Tomography; Prognostic Factor; Progression-Free Survivals; Research; Spectrum Analysis; Surrogate Markers; Time; Toxic effect; Vascular Endothelial Growth Factors; Vascular Permeabilities; Work; antitumor agent; bevacizumab; drug efficacy; experience; gadolinium oxide; imaging modality; neuro-oncology; response; success; tumor; tumor progression; two-dimensional

There are several sections of this project involving different aspects of imaging. 1. MR sequences: We are currently working in the Laboratory of Diagnostic Radiology Research evaluating multiple MR sequences on children with brain tumors, longitudinally, to assess outcome to tehrapy and prognostic factors. These imaging modalities include spectroscopy (single voxel, CSI and multislice multivoxel), perfusion studies (DEMRI, DSC-MRI) and diffusion tenor imaging. 2. Results from NMRS are being compared to the "gold standard" in adult neuro-oncology, i.e. FDG-PET, to determine the correlation between results of each modality.

该项目有几个部分涉及成像的不同方面。 1。MR序列：我们目前正在诊断放射学研究实验室工作，该研究评估了对脑肿瘤儿童（纵向）的多个MR序列，以评估Tehrapy和预后因素的结果。这些成像方式包括光谱（单素体素，CSI和多疗多毒素），灌注研究（DEMRI，DSC-MRI）和扩散男高音成像。 2。正在将NMR与成人神经肿瘤学（即FDG-PET）中的“黄金标准”进行比较，以确定每种模式的结果之间的相关性。