Understanding Emotion and Social Impairment in Schizophrenia

了解精神分裂症的情绪和社交障碍

• 批准号: 8246422
• 负责人: JACK J. BLANCHARD
• 金额: $ 12.64万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-08 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8246422
• 关键词: 18 year old; Adult; Affect; Affective; Anhedonia; Area; Basic Science; Behavior; Behavioral; Characteristics; Clinical; Clip; Collaborations; Communities; Complement; Consult; Consultations; Coupled; Development; Development Plans; Disease; Educational workshop; Electroencephalography; Emotional; Emotions; Family Relationship; Film; Food; Foxes; Functional disorder; Funding; Future; Goals; Impairment; Independent Scientist Award; Individual Differences; Intervention; Left; Longitudinal Studies; Maryland; Mentors; Methods; Neurocognitive Deficit; Neurosciences; Neurosciences Research; Outcome; Patient Self-Report; Pattern; Performance; Procedures; Psychophysiology; Relative (related person); Research; Research Activity; Research Methodology; Research Personnel; Risk; Role; Sampling; Schizophrenia; Social Behavior; Social Interaction; Social support; Socialization; Stimulus; Sum; Temperament; Testing; Time; Training; Translational Research; Withdrawal; affection; affective neuroscience; base; career development; cohort; developmental psychology; follow-up; indexing; meetings; neuropsychological; peer; response; skills; social; social group; social neuroscience; trait; young adult

DESCRIPTION (provided by applicant): This is an application for an Independent Scientist Award (K02) that would enable the PI to further develop his research on emotional and social impairment within schizophrenia. The career development plan will allow the PI to obtain training in affective and social neuroscience research that can then serve as the basis for additional translational research in the study and treatment of schizophrenia. This training will involve the following interrelated areas: developmental perspectives on peer relationship formation and socialization, developmental approaches to the understanding of individual differences in temperament and emotion, psychophysiological methods in the study of emotion, and social neuroscience approaches to the study of social behavior and emotion. These career development goals will be met through consultation, research activities, and collaborations with senior researchers in the areas of developmental psychology, basic emotion research, and social neuroscience. Classroom and technical training as well as attendance at scientific meetings and workshops will complement these consulting activities. The proposed didactic and career development activities are closely coupled with the research plan that is, in part, based on the PI's current funded research on anhedonia in schizophrenia and schizotypy (R01 MH512460). Ongoing and planned research will focus on understanding how emotion is altered in schizotypy and schizophrenia including how these emotional changes contribute to disturbances in affiliation and resulting social impairment. This research will span community samples involving schizophrenia-spectrum disorders as well as planned studies on schizophrenia. In sum, an Independent Scientist Award will provide the needed protected time for the PI to develop new skills in the study of emotion and social behavior from a basic science perspective. These new skills will be applied by the PI to future translational research aimed at understanding the profound emotional and social deficits occurring in schizophrenia and will have direct benefit to the development of future interventions in schizophrenia.

描述（由申请人提供）：这是一份独立科学家奖（K02）的申请，该奖将使 PI 能够进一步发展他对精神分裂症情绪和社交障碍的研究。职业发展计划将使 PI 能够获得情感和社会神经科学研究方面的培训，然后可以作为精神分裂症研究和治疗方面其他转化研究的基础。该培训将涉及以下相互关联的领域：同伴关系形成和社会化的发展视角、理解气质和情绪个体差异的发展方法、研究情绪的心理生理学方法以及研究社会行为和社会化的社会神经科学方法。情感。这些职业发展目标将通过咨询、研究活动以及与发展心理学、基础情感研究和社会神经科学领域的高级研究人员的合作来实现。课堂和技术培训以及参加科学会议和研讨会将补充这些咨询活动。拟议的教学和职业发展活动与研究计划密切相关，该研究计划部分基于 PI 当前资助的精神分裂症和精神分裂症快感缺失研究 (R01 MH512460)。正在进行和计划中的研究将侧重于了解精神分裂症和精神分裂症中情绪如何改变，包括这些情绪变化如何导致归属感障碍和由此产生的社交障碍。这项研究将涵盖涉及精神分裂症谱系疾病的社区样本以及计划中的精神分裂症研究。总之，独立科学家奖将为 PI 提供所需的受保护时间，以从基础科学的角度发展情感和社会行为研究的新技能。这些新技能将被 PI 应用到未来的转化研究中，旨在了解精神分裂症中发生的深刻的情感和社交缺陷，并将直接有利于精神分裂症未来干预措施的发展。

项目成果

Social anhedonia and affiliation: examining behavior and subjective reactions within a social interaction.

社交快感缺乏和归属感：检查社交互动中的行为和主观反应。

• DOI: 10.1016/j.psychres.2012.07.050
• 发表时间: 2012
• 期刊: Psychiatry research
• 影响因子: 11.3
• 作者: Llerena,Katiah;Park,StephanieG;Couture,ShannonM;Blanchard,JackJ
• 通讯作者: Blanchard,JackJ

Is social anhedonia related to emotional responsivity and expressivity? A laboratory study in women.

• DOI: 10.1016/j.schres.2010.06.012
• 发表时间: 2010-12
• 期刊: SCHIZOPHRENIA RESEARCH
• 影响因子: 4.5
• 作者: Leung, Winnie W.;Couture, Shannon M.;Blanchard, Jack J.;Lin, Stephanie;Llerena, Katiah
• 通讯作者: Llerena, Katiah