Clinical Research and Assay Support

临床研究和检测支持

• 批准号: 8350166
• 负责人: Mary Walter
• 金额: $ 167.89万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8350166
• 关键词: Accounting; Aliquot; Biological Assay; Biological Markers; Biological Preservation; Blood; Clinical; Clinical Research; Collection; DNA; Data; Databases; Diabetes Mellitus; Endocrine; Ensure; Enteroglucagon; Genomics; Goals; Hormones; Hour; Human; Instruction; Label; Leptin; Liquid substance; Measurement; Measures; Metabolic; Methods; National Institute of Diabetes and Digestive and Kidney Diseases; Online Systems; Oxidative Stress; Plasma; Preparation; Principal Investigator; Process; Protocols documentation; Research; Research Personnel; Sampling; Services; Specimen; Statutes and Laws; System; Technology; Testing; Tube; Whole Blood; adipokines; adiponectin; biobank; cytokine; des-n-octanoyl ghrelin; ghrelin; glucagon-like peptide; programs; trend

The Clinical Research Core is responsible for processing human samples from numerous clinical studies currently in progress. Once the samples are acquired we process it according to the instructions on the protocol, aliquot, label and store the samples for the various principal investigators as per their instructions. We are currently processing an average of 986 samples/week. All samples processed in the lab are set up with a tracking number and entered into a database which is maintained by the Core lab. Studies that have started since January 2008 are labeled using a 2D-barcode system. In addition to the biorepository needs of the PIs, the Clinical Research Core also provides assay services for analyses which are currently not available at DLM. We have tested and validated numerous methods to measure total and active Glucagon-like Peptide-1, Acyl Ghrelin, Desacyl Ghrelin, Leptin, Adiponectin, Oxyntomodulin and several other markers in human plasma.

临床研究核心负责处理目前正在进行的许多临床研究的人类样本。 获取样品后，我们根据协议的说明，等分试样，标记和存储各种主要研究人员的样品，按照其说明进行处理。 我们目前平均每周处理986个样本。 实验室中处理的所有样本均使用跟踪号进行设置，并输入由Core Lab维护的数据库。自2008年1月以来开始的研究使用2D-Barcode系统标记。 除了PIS的生物验证需求外，临床研究核心还为DLM目前尚不可用的分析提供了测定服务。 我们已经测试并验证了众多方法，用于测量人类血浆中总血浆中总和活跃的胰高血糖素样肽-1，酰基生长素蛋白，乙酰生长素蛋白，瘦素，脂联素，氧胞毒素和其他几种标记。