Neuroimaging Core Facility

神经影像核心设施

• 批准号: 8342307
• 负责人: Daniel Weinberger
• 金额: $ 51.26万
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8342307
• 关键词: Affect; Biological; Brain; Brain Diseases; Clinical; Clinical Investigator; Cognition; Complex; Computers; Copying Processes; Core Facility; Data; Data Analyses; Data Set; Diagnostic Procedure; Diffusion Magnetic Resonance Imaging; Equipment; Functional Magnetic Resonance Imaging; Galvanic Skin Response; Genes; Genetic Variation; Genomics; Goals; Image; Image Analysis; Imaging Techniques; Inpatients; Intervention; Knowledge; Laboratories; MRI Scans; Magnetic Resonance Imaging; Maintenance; Manuals; Measurement; Measures; Medical; Mental disorders; Methods; Modality; Multimodal Imaging; Patients; Phenotype; Physicians; Physiological; Procedures; Productivity; Protocols documentation; Psychotic Disorders; Pulse Pressure; Quality Control; Relative (related person); Research; Research Personnel; Schizophrenia; Services; Siblings; Specialist; Spectrum Analysis; Supervision; Surface; Techniques; Training; United States National Institutes of Health; Update; base; computerized data processing; data mining; distributed data; high standard; improved; interest; neuroimaging; operation; programs

The GCAP Neuroimaging Core implements quality control procedures, optimizes and updates imaging protocols, and collects all clinical imaging data from the CBDB sibling and inpatient studies, and maintains and analyzes all structural, spectroscopy, DTI, and large scale archival fMRI data used in these studies. The Neuroimaging Core covers the following neuroimaging domains: 1. Structural MRI: acquisition, quality control, segmentation, automated and manual regions-of-interest (ROI) definition and measurements, surface extraction; 2. Functional MRI: acquisition, quality control, preprocessing, standardized analyses; 3. Spectroscopy: acquisition, quality control, preprocessing, ROI-based and voxel-based; 4. DTI: acquisition, quality control, preprocessing; 5. Implementing new MRI techniques. The Neuroimaging Core subserves the following functions: 1. Medical coverage and image acquisition, image quality control (for data acquired by the core); 2. Maintenance of stimulation equipment, liaison with other NIH imaging core facilities; 3. Implementing and maintaining acquisition of physiological measurements and interventions, (e.g. galvanic skin response, pupillometry, pulse pressure); 4. Creates and updates a manual of MR acquisition and data analysis methods; 5. Training and supervising of research assistants and fellows in neuroimaging methods and analysis; 6. Perform standardized analyses and analysis quality control; and 7. Data mining and distributing of raw and processed data to GCAP investigators; integration with genomic and other scientific data maintained within GCAP. It is expected that other imaging studies performed in GCAP may use the Neuroimaging Core protocols and facilities for those parts (such as structural MRI scanning) it can perform to facilitate integrating and relating these data to the larger archival datasets. To function clinically, the core requires the participation of several staff physicians to perform data mining and analysis functions; requires computer specialists, and a fairly large group of research assistants who rotate between imaging and image analyses and are trained to maintain a standard level of knowledge in imaging and analysis. Day-to-day operation of the core is overseen by the Director of the Neuroimaging Core. Neuroimaging Core's strategy and supervision is under the direction of the Director of the Genes, Cognition and Psychosis Program and a panel consisting of clinical investigators and the Clinical and Scientific Directors.

GCAP神经成像核心核心实现质量控制程序，优化和更新成像协议，并从CBDB同胞和住院研究中收集所有临床成像数据，并维持和分析所有结构性，情视镜，DTI以及这些研究中使用的大型FMRI数据。 神经成像核心涵盖以下神经影像学域： 1。结构MRI：获取，质量控制，分割，自动化和手动区域（ROI）定义和测量，表面提取； 2。功能性MRI：获取，质量控制，预处理，标准化分析； 3。光谱：采集，质量控制，预处理，基于ROI的基于ROI和基于体素； 4。DTI：获取，质量控制，预处理； 5。实施新的MRI技术。 神经成像核心范围可用于以下功能： 1。医疗覆盖范围和图像获取，图像质量控制（对于由核心获取的数据）； 2。维护刺激设备，与其他NIH成像核心设施联络； 3。实施和维持生理测量和干预措施的获取（例如电能皮肤反应，瞳孔测定法，脉压）； 4。创建和更新MR采集和数据分析方法的手册； 5。在神经影像学方法和分析中培训和监督研究助手和研究员； 6。执行标准化分析和分析质量控制；和 7。将原始数据和经过处理的数据挖掘和分发给GCAP研究人员；与GCAP中维持的基因组和其他科学数据的整合。 可以预期，在GCAP中进行的其他成像研究可能会为这些部分（例如结构性MRI扫描）使用神经成像核心方案和设施，以促进将这些数据集成和将这些数据与较大的档案数据集进行集成和关联。 要在临床上发挥作用，核心要求几位员工的医生参与执行数据挖掘和分析功能。需要计算机专家，以及相当大的研究助理，他们在成像和图像分析之间旋转，并接受培训以保持成像和分析方面的标准知识水平。核心的日常操作由神经成像核心主管监督。 神经影像核心的策略和监督在基因，认知和精神病计划主任的指导下，以及由临床研究人员以及临床和科学主管组成的小组。