Building Capacity for Cardiometabolic Outcomes Research

心脏代谢结果研究能力建设

• 批准号: 8383303
• 负责人: Monika M Safford
• 金额: $ 11.65万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-17 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8383303
• 关键词: Acute; Age; Alabama; Appointment; Area; Award; Blood Pressure; Cardiovascular Diseases; Caring; Clinical; Cohort Studies; Communities; Complex; Coronary heart disease; Counseling; Data; Data Analyses; Data Files; Data Sources; Diabetes Mellitus; Diffusion of Innovation; Disease; Disease Outcome; Education; Educational process of instructing; Effectiveness; Environment; Failure; Fellowship; Fellowship Program; Fostering; Funding; Generic Drugs; Glycosylated hemoglobin A; Goals; Health; Health Services Research; Healthcare; Hearing; Heart failure; Individual; Intervention; K-Series Research Career Programs; Leadership; Life; Link; Lipids; Medical Records; Medicare; Medicine; Mentors; Mentorship; National Heart, Lung, and Blood Institute; National Institute of Neurological Disorders and Stroke; Non-Insulin-Dependent Diabetes Mellitus; Nursing Faculty; Outcome; Outcomes Research; Patients; Peer Review; Pharmaceutical Preparations; Pilot Projects; Population; Positioning Attribute; Principal Investigator; Process; Publishing; Quality of Care; Randomized; Reasons for Geographic And Racial Differences in Stroke; Reporting; Research; Research Personnel; Resources; Risk Factors; Role; Rural Community; Stroke; Testing; Time; Training; Underserved Population; Universities; Work; acute coronary syndrome; acute stroke; base; cardiovascular risk factor; career; cohort; design; effectiveness research; experience; geographic difference; implementation research; implementation trial; improved; medication compliance; next generation; novel; patient oriented; patient oriented research; peer; professor; programs; prospective; racial difference; regional difference; skills; success; theories; therapy design; therapy development

DESCRIPTION (provided by applicant): Monika M. Safford, MD is Associate Professor of Medicine at the University of Alabama at Birmingham (UAB), where she has built a successful research program in observational and implementation research. This proposed award will permit her to consolidate her effort to continue her mentoring activities while also building her research program in two main areas: 1) in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study, a community-dwelling prospective cohort of 30,239 Black and White individuals; and 2) the Encourage program, which consists of two large extramurally funded group-randomized implementation trials of peer support interventions to improve cardiometabolic parameters in individuals with diabetes. Her main scientific career goals are to better understand underlying reasons for regional and racial disparities in acute CHD outcomes, and to test interventions designed to improve them, with a focus on underserved populations and complex patients, especially those with diabetes. Since focusing her career on cardiometabolic research 13 years ago, she has maintained uninterrupted federal funding totaling over $17 million as Principal Investigator (PI) and has published 159 peer-reviewed reports. Over this time, she has also fostered the academic research careers of 18 clinical fellows and junior clinical faculty, many of whom now have successful independent research careers in patient-oriented research. Her position as Co-PI of the UAB Health Services Research (HSR) Fellowship, which includes 18 Fellows at any time, assures a steady supply of potential mentees. Her Mentoring Aims are to continue to build her teaching and mentoring skills, and to continue to provide outstanding mentorship to mentees and trainees through her research program, leveraging her leadership roles in the UAB HSR Fellowship program and the UAB Center for Outcomes and Effectiveness Research and Education to select promising candidates for training throughout the award period. Her Research Aims are 1) to build on her current work to study the link between processes of care and outcomes for acute coronary syndrome and hear failure, by adding Medicare and Area Resource File data to the REGARDS study data, testing hypotheses generated by her current work; 4 mentees will receive training while conducting these studies with the candidate; 2) In the Encourage program, to conduct a pilot study that takes the next step in her intervention work, developing an intervention guided by Roger's Diffusion of Innovations theory to spread the acceptability of generic medication use via peer supporters, aiming to test the hypothesis that the intervention will improve medication adherence and, in turn, cardiometabolic risk factor levels; 4 mentees will receive training and conduct these studies with the candidate. In the strongly supportive and collaborative environment of UAB, this award will permit Dr. Safford to continue to build her research program as well as capitalizing on her deep commitment to mentoring, now including six career development award recipients, as well as four T-32 fellows.

描述（由申请人提供）：医学博士 Monika M. Safford 是阿拉巴马大学伯明翰分校 (UAB) 的医学副教授，她在观察和实施研究方面建立了一个成功的研究项目。该拟议奖项将使她能够巩固自己的努力，继续开展指导活动，同时在两个主要领域建立她的研究计划：1）中风地理和种族差异的原因（REGARDS）研究，这是一项居住在社区的前瞻性队列30,239 名黑人和白人； 2) 鼓励计划，包括两项大型外部资助的小组随机实施同伴支持干预试验，以改善糖尿病患者的心脏代谢参数。她的主要科学职业目标是更好地了解急性冠心病结果地区和种族差异的根本原因，并测试旨在改善这些结果的干预措施，重点关注服务不足的人群和复杂的患者，尤其是糖尿病患者。自从 13 年前专注于心脏代谢研究以来，她作为首席研究员 (PI) 一直不间断地获得联邦资助，总额超过 1700 万美元，并发表了 159 份同行评审报告。在此期间，她还培养了 18 名临床研究员和初级临床教员的学术研究生涯，其中许多人现在在以患者为导向的研究领域拥有成功的独立研究生涯。她担任 UAB 健康服务研究 (HSR) 奖学金的联合 PI，该奖学金随时包括 18 名研究员，确保了潜在学员的稳定供应。她的指导目标是继续培养她的教学和指导技能，并利用她在 UAB HSR 奖学金计划和 UAB 结果和有效性研究中心的领导作用，继续通过她的研究项目为受训者和受训者提供出色的指导。教育在整个奖励期内选择有前途的候选人进行培训。她的研究目标是 1) 在她目前的工作基础上，通过将医疗保险和地区资源文件数据添加到 REGARDS 研究数据中，研究急性冠状动脉综合征和听力衰竭的护理过程和结果之间的联系，测试她当前产生的假设工作; 4 名受训者将在与候选人一起进行这些研究的同时接受培训； 2) 在鼓励计划中，开展一项试点研究，以推动她的干预工作的下一步，制定以罗杰的创新扩散理论为指导的干预措施，通过同行支持者传播仿制药使用的可接受性，旨在检验以下假设：该干预措施将提高药物依从性，进而提高心脏代谢危险因素水平； 4 名学员将接受培训并与候选人一起进行这些研究。在 UAB 的大力支持和协作环境中，该奖项将使 Safford 博士能够继续建立她的研究计划，并利用她对指导的坚定承诺，目前包括六名职业发展奖获得者以及四名 T-32各位。