Adapting and Pilot Testing a Behavioral Intervention to Incorporate Advances in HIV Prevention for Black Young MSM in Alabama

调整和试点测试行为干预措施，以纳入阿拉巴马州黑人青年 MSM 的艾滋病毒预防进展

• 批准号: 9927669
• 负责人: Henna Budhwani
• 金额: $ 17.94万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-08 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9927669
• 关键词: AIDS prevention; AIDS/HIV problem; Acute; Address; Adolescent Medicine Trials Network; Age; Alabama; Attention; Awareness; Behavior Therapy; Belief; Brothers; Clinic Visits; Clinical; Code; Color; Communities; Country; Data; Data Analyses; Deep South; Development; Doctor of Philosophy; Education; Effectiveness; Environment; Epidemic; Focus Groups; Funding; Goals; HIV; HIV Infections; HIV risk; Health; Home environment; Human immunodeficiency virus test; Hybrids; Infection; Infrastructure; Institution; Intervention; Interview; Knowledge; Learning; Link; Mentored Research Scientist Development Award; Mentors; Methods; Midwestern United States; Minority; Modeling; Modernization; Morbidity - disease rate; Outcome; Participant; Perception; Pilot Projects; Population; Positioning Attribute; Prevention education; Process; Public Health; Qualitative Methods; Qualitative Research; Randomized; Randomized Controlled Trials; Research; Research Methodology; Research Personnel; Savings; Scientist; Stigmatization; Structure; Subgroup; Target Populations; Testing; Time; Training; United States; Universities; Update; Work; Youth; base; brief intervention; effectiveness implementation trial; effectiveness testing; eligible participant; experience; health disparity; implementation science; intersectionality; intervention effect; member; men who have sex with men; mortality; outreach; peer; pilot trial; pre-exposure prophylaxis; prevention service; racial minority; research study; same sex behavior; skills; social; social stigma; social structure; success; testing services; theories; therapy development; tool; transgender women; transmission process; trial design; young men who have sex with men

PROJECT SUMMARY The overall goal of this 5-year Mentored Research Scientist Development K01-Award is to support Henna Budhwani, PhD, MPH become an independent investigator in the field of HIV prevention. The proposed project seeks to address the HIV crisis in Alabama, where rates of undiagnosed HIV in black young men who have sex with men (YMSM, 18-29 years) exceed 20%. This project will adapt and test a behavioral intervention to promote HIV rapid testing in the community, deliver culturally appropriate prevention education, offer sociostructural supports, and refer eligible participants for pre-exposure prophylaxis (PrEP). Four training objectives are proposed that are in lockstep with three specific aims. Objective 1 includes an intensive training and mentoring plan in social theory including theories of intersectionality and emerging masculinities. Objective 2 includes in- depth training on qualitative research methods including how to conduct focus groups, in-depth interviews, and qualitative data analysis. Aim 1, which will be conducted after Objective 2, is to elucidate experiences, beliefs, and predictors related to delivery and utilization of HIV testing and prevention services by black YMSM using qualitative research methods, namely in-depth interviews with HIV outreach staff, focus groups with black YMSM, and in-depth interviews with members of key sub-groups (e.g. transgender women) to inform the adaptation of the Brothers Saving Brothers (BSB) intervention. Objective 3 includes didactic and hands-on training on how to scientifically adapt HIV behavioral interventions using validated frameworks, such as intervention mapping. Aim 2 is to adapt the BSB intervention to include two HIV prevention tools (rapid testing and PrEP), to address structural barriers, and to be acceptable to black YMSM in Alabama. Objective 4 includes comprehensive training and mentoring in the field of implementation science. Aim 3, which concludes the proposed research study and K01 project, is to conduct a hybrid type 1 effectiveness-implementation pilot study of the adapted intervention in which the candidate will a) assess acceptability and feasibility of adapted BSB (aBSB); b) preliminarily estimate effects on HIV prevention outcomes; and c) collect data on real-world implementation. These aims will be accomplished by collaborating with two community-based organizations that are well-respected for their HIV prevention work in study communities. This rigorous project includes intensive training at the candidate's home university, the University of Alabama at Birmingham (UAB) and from other prominent institutions that offer very specific training not found at UAB; engagement within the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN); comprehensive mentoring from senior HIV researchers with expertise in minority, youth, and MSM health; and a thoughtful research strategy that addresses significant threats, high rates of undiagnosed HIV and insufficient engagement with HIV prevention services, including PrEP, in black YMSM in Alabama. The combination of the proposed mentoring and training with study findings will culminate in the candidate's attainment of independence and development of a full-scale, implementation science R01 proposal to test aBSB.

项目概要 这个为期 5 年的指导研究科学家发展 K01 奖的总体目标是支持 Henna Budhwani 博士、公共卫生硕士成为艾滋病预防领域的独立研究者。拟议项目 寻求解决阿拉巴马州的艾滋病毒危机，该州发生性行为的黑人年轻男性中未确诊艾滋病毒的比例 男性（YMSM，18-29 岁）超过 20%。该项目将调整和测试行为干预以促进 在社区进行艾滋病毒快速检测，提供适合文化的预防教育，提供社会结构 支持并转介符合资格的参与者进行暴露前预防 (PrEP)。四个培训目标是 提议与三个具体目标保持一致。目标 1 包括强化培训和指导 社会理论计划，包括交叉性和新兴男性气质理论。目标 2 包括 - 定性研究方法的深度培训，包括如何进行焦点小组、深度访谈和 定性数据分析。目标 1 将在目标 2 之后进行，是阐明经验、信念、 与黑人 YMSM 提供和利用艾滋病毒检测和预防服务相关的预测因素 定性研究方法，即对艾滋病毒外展人员进行深入访谈、黑人 YMSM 焦点小组， 以及对关键亚群体成员（例如跨性别女性）的深入访谈，以了解如何适应 兄弟拯救兄弟会（BSB）的干预。目标 3 包括关于如何 使用经过验证的框架（例如干预图）科学地调整艾滋病毒行为干预措施。目的 2 是调整 BSB 干预措施，纳入两种艾滋病毒预防工具（快速检测和 PrEP），以解决 结构性障碍，并为阿拉巴马州黑人 YMSM 所接受。目标 4 包括综合培训 以及实施科学领域的指导。目标 3，总结拟议的研究和 K01项目，旨在对适应干预措施进行混合1型有效性实施试点研究 候选人将 a) 评估改编 BSB (aBSB) 的可接受性和可行性； b) 初步估计 对艾滋病毒预防结果的影响； c) 收集实际实施情况的数据。这些目标将是 这是通过与两个因艾滋病毒而受到尊重的社区组织合作完成的 研究社区的预防工作。这个严格的项目包括在候选人家中进行强化培训 大学、阿拉巴马大学伯明翰分校 (UAB) 以及其他提供非常 UAB 没有提供具体培训；参与艾滋病毒/艾滋病青少年医学试验网络 干预措施（ATN）；由具有少数民族、青年、 和男男性行为者的健康；以及一个深思熟虑的研究策略，解决重大威胁、高未确诊率 阿拉巴马州黑人 YMSM 中的艾滋病毒和对艾滋病毒预防服务（包括 PrEP）的参与不足。这 将拟议的指导和培训与研究结果相结合，最终将使候选人 实现独立性并开发全面的、实施科学的 R01 提案来测试 aBSB。