REGARDS - MI Study

问候 - MI 研究

• 批准号: 7816309
• 负责人: Monika M Safford
• 金额: $ 2.45万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7816309
• 关键词: Acute; Address; African American; Age; American; Ancillary Study; Area; Cardiac; Caring; Case Fatality Rates; Cause of Death; Cessation of life; Coronary; Coronary heart disease; Data; Data Collection; Economic Factors; Ethnic Origin; European; Event; Female; Funding; Geography; Goals; Healthy People 2010; Heart; Heart Diseases; Hospitalization; Hospitals; Hypertension; Incidence; Individual; Knowledge; Medical; Medical Records; Mississippi; Myocardial Infarction; National Institute of Neurological Disorders and Stroke; Observational Study; Ohio; Outcome; Participant; Pharmaceutical Preparations; Plant Roots; Population; Predisposition; Prevalence; Prevention; Procedures; Public Health; Reasons for Geographic And Racial Differences in Stroke; Recruitment Activity; Recurrence; Research Infrastructure; Research Personnel; Risk Factors; Rivers; Sampling; Services; Socioeconomic Factors; Stroke; Testing; United States National Institutes of Health; Variant; Woman; base; cost; follow-up; geographic difference; health disparity; heart disease risk; insight; knowledge base; meetings; men; mortality; programs; racial difference

BACKGROUND. As for stroke, geographic and ethnic variations in CHD mortality are recognized but poorly understood. NIH (NINDS) funded the Reasons for Geographic And Racial Differences in Stroke (REGARDS) study to follow 30,000 individuals(age >44; 1/2 African American, 1/2 European American; 1/2 female; 1/2 from the stroke belt/ buckle areas) over 3.5 years for stroke incidence and mortality. SPECIFIC AIMS. The overall goal of the REGARDS-MI Ancillary Study is to capitalize on a narrow window of opportunity to leverage REGARD'S infrastructure by quantifying geographic and ethnic variations in CHD mortality, attack rates (new and recurrent hospitalized acute CHD and pre-hospital CHD death in the population) and case fatality (among those with an acute CHD event, death within 28 days). Our Specific Aims are to (1) estimate US geographic- and ethnic-specificrates of CHD mortality, attack rates, and case fatality; (2) study the relationshipbetween US geographic- and ethnic-specific attack rates and variation in the prevalence of CHD risk factors; and (3) study the relationship between US geographic- andethnic-specific CHD case fatality and socioeconomic factors, medical care and CHD risk factors. METHODS. We will retrieve medical records for all heart-related hospitalizations(-6000) among REGARDS participants and collect data on all deaths (-500). We will adjudicatehospitalizations and deaths for CHD, collect cardiac procedures and medications, and merge this with extensive data already being collected by REGARDS. Using multivariable multi-levelanalyses, we will test 10 specific hypotheses. IMPLICATIONS. This will be the first nationwidestudy to relate CHD attack rate and case fatality, including pre-hospital deaths, to geographic and ethnic variations in CHD mortality. REGARDS offers aunique opportunity to attain our specific aims without the massive participant recruitment and follow-up costs that otherwise would be necessary. There is no budgetary overlap between REGARDS and REGARDS-MI as REGARDS focuses only on potential strokes. Our results will contribute significantlyto the knowledge base essential for attaining the Healthy People 2010 goal of reducing health disparities.

背景。至于中风，冠心病死亡率的地理和种族差异已得到认可，但认识不足 明白了。 NIH (NINDS) 资助了中风地理和种族差异的原因研究 （问候）研究跟踪 30,000 人（年龄 >44 岁；1/2 非洲裔美国人，1/2 欧洲裔美国人； 1/2 女性； 3.5 年内中风发生率和死亡率的 1/2（来自中风带/带扣区域）。 具体目标。 REGARDS-MI 辅助研究的总体目标是利用狭窄的范围 通过量化地理和种族差异来利用 REGARD 基础设施的机会之窗 CHD 死亡率、发病率（新发和复发的住院急性 CHD 以及院前 CHD 死亡） 人口）和病死率（急性 CHD 事件患者中，28 天内死亡）。我们的具体 目的是 (1) 估计美国特定地理和种族的 CHD 死亡率、发病率和病例 死亡； (2) 研究美国特定地理和种族的攻击率与变异之间的关系 冠心病危险因素的患病率； (3) 研究美国地理和种族特定之间的关系 CHD 病死率和社会经济因素、医疗保健和 CHD 危险因素。 方法。我们将检索其中所有与心脏相关的住院治疗（-6000）的医疗记录 问候参与者并收集所有死亡人数 (-500) 的数据。我们将裁定住院和死亡 对于先心病，收集心脏手术和药物，并将其与已经存在的大量数据合并 由问候收集。使用多变量多水平分析，我们将测试 10 个具体假设。 影响。这将是第一项将冠心病发病率和病死率联系起来的全国性研究，包括 院前死亡、冠心病死亡率的地理和种族差异。 REGARDS 提供独特的 有机会实现我们的特定目标，而无需大量的参与者招募和后续成本 否则将是必要的。 REGARDS 和 REGARDS-MI 之间不存在预算重叠，因为 REGARDS 仅关注潜在的中风。我们的结果将对知识库做出重大贡献 对于实现《2010 年健康人民》缩小健康差距的目标至关重要。