Breast Cancer Family Registry Cohort

乳腺癌家族登记队列

基本信息

批准号：
8374040
负责人：
Irene Andrulis
金额：
$ 272.31万
依托单位：
CANCER PREVENTION INSTIT OF CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-12 至 2017-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8374040
关键词：
Affect Behavior Therapy Behavioral Breast Cancer Prevention Trial Clinical Clinical Research Collaborations Collection Communication Data Epidemiology Family Family Cancer History Family member Genetic screening method Genotype Health behavior Hereditary Breast Carcinoma Hereditary Disease Immunohistochemistry Individual International Knowledge Malignant Neoplasms Molecular Molecular Genetics Outcome Pathology Predisposition Preventive Prospective Studies Protocols documentation Questionnaires Recording of previous events Recurrence Research Research Infrastructure Research Personnel Resources Risk Risk Factors Scientist Screening procedure Site Specimen Translations Tumor Subtype Update Variant Woman base breast cancer family breast cancer family registry cancer risk clinical practice cohort epidemiologic data follow-up gene discovery high risk insight instrument malignant breast neoplasm member men translational study tumor uptake

项目摘要

DESCRIPTION (provided by applicant): The objective of this UM1 application is to maintain and enhance the core infrastructure of the Breast Cancer Family Registry (BCFR), an international resource of multi-generational families established for interdisciplinary collaboratie research on breast cancer. The BCFR Cohort, established in 1995 at 6 sites is comprised of 34,000 individuals from 11,900 families who provided data on family history and epidemiologic risk factors as well as bio specimens. Over the next five years, the BCFR investigator team will continue 1) to actively follow the family cohort using common instruments and protocols, update the cancer family histories to identify new breast and other cancers in the families, and administer a follow-up questionnaire to update baseline epidemiologic data; 2) to maintain the extensive data and bio specimen resources and enhance them by conducting pathology review for all new breast cancers ascertained since baseline, completing molecular sub typing of tumors, and completing genotyping of known common breast cancer susceptibility variants; 3) to collect new data on screening, uptake of risk reductive and preventive health behaviors, knowledge of genetic disease, and uptake of genetic testing and communication to family members that will facilitate the translation of findings into clinical practice; and 4) to continue and expand collaborations with external investigators by sharing of BCFR data and bio specimen resources for a wide range of studies of gene discovery, cancer-related outcomes, risk factors in high-risk individuals, behavioral interventions and cancer prevention trials among at-risk family members. The BCFR Cohort is unique in that it is family-based and the first large prospective study of breast cancer risk for women at a continuum of risk. In addition to the unaffected cohort, the BCFR has one of the largest affected cohorts and will therefore provide a powerful resource for translational and clinical studies of recurrences, second primaries and survival.

描述（由申请人提供）：该UM1申请的目的是维护和增强乳腺癌家族登记处（BCFR）的核心基础设施，这是建立用于跨学科乳腺癌研究的多代家庭的国际资源。 BCFR队列成立于1995年，在6个地点成立，由来自11,900个家庭的34,000名个人组成，他们提供了有关家族史和流行病学风险因素以及生物标本的数据。在接下来的五年中，BCFR调查员团队将继续1）使用普通工具和协议积极关注家庭队列，更新癌症家族历史以识别家庭中的新乳房和其他癌症，并管理后续调查表以更新基准基线流行病学数据； 2）维持广泛的数据和生物标本资源，并通过对自基线以来确定的所有新乳腺癌进行病理审查，完成肿瘤的分子亚键入以及完成已知普通乳腺癌易感变体的基因分型； 3）收集有关筛查的新数据，摄入风险减少和预防性健康行为，遗传疾病知识以及对家人的遗传检测和沟通的吸收，这将有助于将发现转化为临床实践； 4）继续并通过共享BCFR数据和生物标本资源来扩大与外部研究人员的合作，以对基因发现，与癌症相关的结果，高危个人的危险因素，行为干预措施和癌症预防试验的广泛研究。 BCFR队列的独特之处在于它是基于家庭的，并且是对处于风险连续的女性乳腺癌风险的首次大型前瞻性研究。除了未受影响的队列外，BCFR还有受影响最大的队列之一，因此将为复发，第二个初选和生存的转化和临床研究提供强大的资源。