Breast Cancer Family Registry Cohort

乳腺癌家族登记队列

基本信息

批准号：
10180905
负责人：
Irene Andrulis
金额：
$ 200万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-12 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10180905
关键词：
Address Affect Age Australia BRCA1 gene BRCA2 gene Behavioral Big Data Blood Blood specimen Breast Breast Cancer Risk Factor Canada Cancer Etiology Cell Line Cessation of life Characteristics Chemoprevention Clinical Collaborations Collection Communities Complement Complex DNA Data Data Collection Data Linkages Data Set Databases Death Records Development Diagnosis Early identification Enrollment Environmental Exposure Etiology Event Family Family member Family-Based Registry Gene Mutation Generations Genetic Predisposition to Disease Genetic Risk Genomics Genotype Germ-Line Mutation Goals Health behavior Hereditary Breast Carcinoma Hormones Incidence Individual Infrastructure International Intervention Investigation Knowledge Length Life Life Cycle Stages Life Style Malignant Neoplasms Mammary Gland Parenchyma Mammographic Density Mammography Measurement Measures Menstrual cycle Methods Modeling Molecular Newly Diagnosed Operative Surgical Procedures Optics Outcome Participant Pathologic Physical activity Plasma Positioning Attribute Predisposition Pregnancy Prevention Prevention Research Primary Prevention Questionnaires Radiation Recording of previous events Registries Reproductive History Research Resources Risk Risk Assessment Risk Factors Role Scientist Second Primary Cancers Secondary Prevention Site Spectrum Analysis Techniques Technology Testing Tissue Banks Tissue Sample Translational Research Tumor Tissue Update Woman Women&apos s Health aged base breast cancer diagnosis breast cancer family registry cancer epidemiology cancer risk clinical risk cohort data repository design digital digital imaging early detection biomarkers emerging adult ethnic diversity follow-up genetic discrimination genetic variant genomic data improved intervention program malignant breast neoplasm member men mobile application mortality multiple omics new technology novel novel strategies prospective psychosocial public health research racial diversity recruit risk perception risk prediction model screening screening guidelines survivorship targeted treatment tertiary prevention whole genome young adult young woman

项目摘要

The Breast Cancer Family Registry (BCFR) Cohort is a large and well-characterized international cohort of multi-generational families that has been created for interdisciplinary collaborative research. Established in 1995 at six sites across the US, Canada and Australia, we recruited and followed 40,029 individuals (33,037 women and 6,992 men) from 15,056 families across the full spectrum of familial risk and/or genetic predisposition. Through recruitment of multiple family members across generations, the BCFR Cohort is unique from other cohorts of unrelated individuals, and has a wide range of absolute breast cancer risk, which enables investigation of factors that modify breast cancer susceptibility and outcomes after diagnosis across the spectrum of risk. The BCFR Cohort is also unique for its comprehensive biospecimen resources, including cell lines for many participants complementing standard stored DNA, plasma and tissue samples. We have followed individuals who were unaffected (n=27,671) and affected (n=12,358) with breast cancer at baseline for up to 25 years (average length of follow-up = 15.2 and 16.1 years, respectively) and prospectively ascertained 879 incident breast cancers and 863 second breast events, respectively. The overarching goal of this application is to enrich the BCFR Cohort by building upon and enhancing the core infrastructure using long-term prospective data collection and measurement of key markers to address novel hypotheses in cancer etiology, survival and survivorship. We aim to answer questions on the role of life course accumulation of risk, critical windows of exposure, and the factors underling the increase in breast cancer incidence in young women. We propose to continue a systematic and coordinated approach across all six sites over the next five years to: 1) enhance the BCFR Cohort by enrolling young women aged 18–39 years who are relatives of enrolled family members and collecting detailed data on menstrual cycles, hormone exposure and physical activity using mobile app technology; 2) retain and follow currently enrolled members of the BCFR Cohort through another wave of follow-up questionnaires, and linkages to cancer and death registries; 3) create a big data repository of multiple “omics” datasets (e.g., whole genome, serial digital mammograms); and 4) expand the biospecimen resources, including collection of tissue and repeat blood samples. These activities will include collection and updating of detailed risk factor, biospecimen, clinical, and outcome data through novel approaches and technology (e.g., mobile app technologies, optical spectroscopy) and big data approaches. With the addition of these components, we will continue to provide the research community an important and unique family cohort to address cutting-edge research questions of clinical importance on cancer susceptibility, survival and survivorship (e.g., risk assessment, identification of early detection markers, knowledge and perception of risk). Through this resource, we envision a large platform for translational research that will provide rigorous evidence on complex questions related to primary, secondary and tertiary prevention efforts.

乳腺癌家族注册表（BCFR）队列是一个大型且特征良好的国际队列为跨学科合作研究而创建的多代家庭。建立在 1995年在美国，加拿大和澳大利亚的六个地点，我们招募并遵循4029个人（33,037个人妇女和6,992名男性）来自15,056个家庭的家庭风险和/或遗传倾向。通过招募几代人的多个家庭成员，BCFR队列是与其他无关个体的独特性，并且具有广泛的绝对乳腺癌风险，这是可以投资于改变乳腺癌易感性和诊断后的结果的因素风险范围。 BCFR队列也以其全面的生物测量资源（包括许多参与者的细胞系，完成标准存储的DNA，血浆和组织样品。我们有跟随不受影响的人（n = 27,671）并在基线时受到乳腺癌的影响（n = 12,358）长达25年（随访的平均长度= 15.2和16.1岁）和前瞻性确定了879例事件乳腺癌和863次乳腺事件。总体目标该应用程序是通过使用并增强核心基础架构来丰富BCFR队列长期的前瞻性数据收集和关键标记的测量，以解决癌症的新假设病因，生存和生存。我们的目标是回答有关生命课程累积风险的作用的问题，暴露的关键窗口以及年轻人乳腺癌发病率增加的因素女性。我们建议在接下来的五个站点上继续在所有六个站点上进行系统和协调的方法年：1）通过注册18-39岁的年轻妇女，以增强BCFR队列注册的家庭成员并收集有关月经周期，激素暴露和身体的详细数据使用移动应用技术的活动； 2）保留并关注当前招募的BCFR队列成员通过另一浪跟进问卷，与癌症和死亡登记处的联系； 3）创建一个大多个“ OMIC”数据集的数据存储库（例如，全基因组，串行数字乳房X线照片）； 4）扩展生物测量资源，包括收集组织和重复血液样本。这些活动将通过新颖方法和技术（例如，移动应用技术，光谱法）和大数据方法。通过添加这些组件，我们将继续为研究界提供重要的重要性独特的家庭队列，以解决有关临床重要性对癌症敏感性的尖端研究问题，生存和生存（例如，风险评估，早期检测标记的识别，知识和知识和对风险的感知）。通过此资源，我们设想了一个用于转化研究的大型平台就与初级，中学和第三级预防工作有关的复杂问题提供严格的证据。