CLABSIs in Ambulatory Pediatric Oncology Patients

门诊儿科肿瘤患者中的 CLABSI

• 批准号: 8279034
• 负责人: Michael L Rinke
• 金额: $ 13.87万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8279034
• 关键词: CLABSIs; Ambulatory; Pediatric; Oncology; Patients

DESCRIPTION (provided by applicant): The overall goal of this K08 mentored clinical scientist research career development award is to develop Dr. Michael Rinke into an independent clinical investigator in pediatric patient safety and quality, focusing on eliminating ambulatory central line-associated blood stream infections (CLABSIs). This goal will be accomplished during the grant period through doctorate level coursework in survey and cohort designs at the Johns Hopkins Bloomberg School of Public Health, advanced training in patient safety methodologies at Johns Hopkins' Center for Innovation in Quality Patient Care and at the Institute for Health Care Delivery and Research at Intermountain Healthcare, intensive mentorship from experienced health services researchers such as Dr. Marlene Miller, Dr. Allen Chen, Dr. Aaron Milstone and Dr. David Bundy and protected research time focused on CLABSIs in ambulatory pediatric oncology patients. Dr. Rinke's patient safety research aims to understand the epidemiology of ambulatory pediatric oncology patient CLABSIs and evaluate strategies to decrease ambulatory CLABSIs using best-practice care bundles. CLABSIs cause significant morbidity and mortality in all patients and are understudied in ambulatory populations. Dr. Rinke's research will 1) compare the burden of ambulatory pediatric oncology patient CLABSIs to inpatient pediatric oncology patient CLABSIs via CLABSIs counts, and describe specific risk factors and outcomes associated with ambulatory CLABSIs. The proposal will also 2) compare both pediatric homecare agency central line care policies and ambulatory pediatric oncology family central line care practices with best-practice central line care bundles, and describe barriers to implementation of best-practice central line care bundles in these populations. Finally, this proposal will 3) determine whether consistent clinic, homecare agency and family implementation of best-practice central line care bundles is associated with a decrease in ambulatory pediatric oncology patient CLABSI rates. Evaluating strategies to prevent CLABSIs in ambulatory pediatric oncology patients will improve outcomes for this vulnerable population. Successful completion of these projects will allow Dr. Rinke to become an independent clinical investigator and spread ambulatory CLABSI prevention efforts to other institutions and to other ambulatory pediatric and adult populations with long-term central lines. . PUBLIC HEALTH RELEVANCE: This proposal will evaluate strategies to decrease harmful central line-associated blood stream infections in ambulatory pediatric patients. Successful completion will generate an evidence base to prevent central line infections in all care settings, including homes and clinics.

描述（由申请人提供）：这一K08指导的临床科学家研究职业发展奖的总体目标是将迈克尔·林克（Michael Rinke）博士发展成为一名独立的儿科患者安全和质量的临床研究者，重点是消除与卧床中央线相关的血流感染（Clabsis）。这一目标将在赠款期间通过调查和队列设计的博士学位课程在约翰·霍普金斯彭博公共卫生学院的研究和队列设计中实现戴维·邦迪（David Bundy）和保护的研究时间集中在卧床儿科肿瘤患者中。 Rinke博士的患者安全研究旨在了解卧床儿科肿瘤学患者clabsis的流行病学，并评估使用最佳实践护理捆绑包来减少门诊的策略。 clabsis在所有患者中引起明显的发病率和死亡率，并且在门诊人群中被研究了。 Rinke博士的研究将1）比较卧床儿科肿瘤学患者的负担与住院儿科肿瘤学通过clabsis计数的负担，并描述与卧床性clabsis相关的特定危险因素和结果。该提案还将2）比较小儿居家机构中央线护理政策和门诊小儿肿瘤科家庭中心线护理实践与最佳实践中心线护理捆绑包，并描述了在这些人群中实施最佳实践中央线护理捆绑包的障碍。最后，该提案将3）确定一致的诊所，家庭保健机构和家庭最佳练习中心线护理束的实施是否与卧床儿科肿瘤学患者CLABSI率的降低有关。评估防止卧床儿科肿瘤学患者中的神经质的策略将改善这种脆弱人群的预后。这些项目的成功完成将使Rinke博士成为一名独立的临床研究者，并向其他机构以及具有长期中央线的其他机构以及其他卧床儿科和成年人种群传播卧床性Clabsi的预防工作。 。 公共卫生相关性：该提案将评估策略，以减少卧床儿科患者中与中枢相关的有害中心线相关的血流感染。成功完成将产生证据基础，以防止在包括房屋和诊所在内的所有护理环境中中央感染。