GWAS FOR CARDIOVASCULAR HEALTH IN ELDERLY PUERTO RICANS

GWAS 促进波多黎各老年人的心血管健康

基本信息

批准号：
8238326
负责人：
Jose M. Ordovas
金额：
$ 25.5万
依托单位：
NORTHEASTERN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-04-01 至 2015-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8238326
关键词：
Acculturation Admixture Adult Affect Biochemistry Bioinformatics Biological Biological Markers Blood Vessels Boston Cardiovascular Diseases Cardiovascular system Characteristics Chronic Chronic Disease Cohort Studies Complement Conflict (Psychology)Copy Number Polymorphism DNA DNA Biochemistry Data Data Set Detection Development Diabetes Mellitus Diagnosis Diet Dietary intake Disease Elderly Environment Ethnic group Europe Foundations Funding Gene Targeting Genes Genetic Genetic Markers Genotype Goals Health Health behavior High Prevalence Hispanics Human Hypertension Impaired cognition Individual Interview Knowledge Life Life Style Lipids Logistic Regressions Longitudinal Studies Measures Memory Minority Minority Groups Mission Modeling National Institute of Mental Health Non-Insulin-Dependent Diabetes Mellitus Not Hispanic or Latino Outcome Pattern Pharmaceutical Preparations Phenotype Physical activity Population Population Genetics Population Sizes Premature aging syndrome Prevalence Prevention strategy Public Health Puerto Rican Questionnaires Relative (related person)Reporting Research Research Personnel Resources Risk Risk Factors Single Nucleotide Polymorphism Socioeconomic Status Speed Strategic Planning Stress Technology Testing United States United States National Institutes of Health Validation Vulnerable Populations Work age group aged aging nutrition base cardiovascular disorder risk cohort demographics disability disorder risk follow-up genetic analysis genetic association genetic variant genome wide association study genome-wide health disparity high risk improved novel population health racial and ethnic socioeconomics success tool

项目摘要

The rapid developments in genetic analyses have opened an exciting chapter in population health. There has been a tremendous rise in the reporting of genes and pol5Tnorphisms potentially impacting health outcomes. In particular, genome wide scanning technology and bioinformatics are providing exciting information on disease risk. However, most available data, and particularly genome-wide association (GWAS) studies, are based on non-Hispanic white populations. With the projected increase ofthe US Hispanic population and the rise of health disparities in this population, their inclusipn in genetic studies is imperative. We provide a unique resource, in that we have a cohort of Puerto Rican adults with DNA available, and extensive and detailed phenotypic data. To our knowledge, this is the largest cohort study of Puerto Ricans of this type. The genetics of this population has not been studied before to this extent and intensity, and this will, therefore, complement the goals ofthe GWAS consortium. We vAW focus on two prevalent conditions seen in excess in this population: hypertension and type 2 diabetes as it relates to cardiovascular disease (CVD). Within our NIH funded Center on Population Health and Health Disparities (CPHHD, 5P01-AG023394), we have a longitudinal study of 1450 Puerto Rican adults, aged 45-75 y. The study includes data on demographics, socio-economics, dietary intake and health behaviors, anthropometric measures, biochemistries and genot5q)es of over 150 genetic variants. Further, we have already completed 2-year-interviews of more than 900 subjects in our ongoing follow-up. GWAS will provide an efficient way to advance our understanding of health disparities and, as a population with excess risk, to identify novel genetic contributors to these conditions. Using GWAS in conjunction with in-depth bioinformatic analyses, we will further prioritize 450 SNPs that are associated with CVD and risk. Selected SNPs will be replicated in other two populations: the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN), for which a GWAS is being conducted in our laboratotory, and the Nutrition, Aging, and Memory in Elders Study (NAME), an elderly cohort which has enriched phenotypes for vascular health and high prevalance of h3T)ertension and diabetes. Building on findings from the four other projects, we will explore genotype interaction with environmental variables, including diet, physical activity, acculturation and measures of stress to increase understanding ofthe risk of CVD. While the population size may appear small, the high prevalence of chronic diseases, such as hypertension and diabetes in this population and our success in detecting genetic associations for CVD and risk demonstrate the sufficient power of this population for GWAS. The findings from this study combined with those ofthe four other projects vnll allow us to (1) provide a fiill spectrum of genetic characteristics of CVD of this population; (2) create the foundation for a new understanding of health disparities in terms of genetics and environment (diets and lifestyle); (3) confirm potential genetic relationships in two additional populations.

遗传分析的快速发展为人口健康开辟了令人兴奋的一章。有基因的报告和POL5TNORPHISS的报告可能会影响健康结果。特别是，基因组广泛的扫描技术和生物信息学正在提供有关令人兴奋的信息疾病风险。但是，大多数可用数据，尤其是全基因组关联（GWAS）研究，是基于非西班牙裔白人种群。随着美国西班牙裔人口的预计增加在这个人群中，健康差异的上升是，他们在遗传研究中的含义是必须的。我们提供一个独特的资源，因为我们有一群可提供DNA的波多黎各人，而且广泛，详细的表型数据。据我们所知，这是对这类波多黎各人的最大队列研究。这在此之前和强度之前，尚未对该人群的遗传学进行研究，因此，这将补充GWAS财团的目标。我们关注的是两个普遍的条件该人群：与心血管疾病（CVD）有关的高血压和2型糖尿病。在我们内部 NIH资助的人口健康与健康差异中心（CPHHD，5P01-AG023394），我们有一个 1450名波多黎各成年人的纵向研究，年龄45-75岁。该研究包括有关人口统计数据的数据，社会经济，饮食摄入和健康行为，人体测量措施，生物化学和超过150种遗传变异的Genot5q）ES。此外，我们已经完成了超过我们正在进行的后续行动中有900名受试者。 GWAS将提供一种有效的方法来提高我们对健康差异，并且作为具有过多风险的人群，以确定这些新的遗传因素状况。将GWAS与深入的生物信息学分析结合使用，我们将进一步优先考虑450 与CVD和风险相关的SNP。选定的SNP将在其他两个人群中复制：脂质降低药物和饮食网络（GOLDN）的遗传学，在我们的 Laboratotory，以及长者研究（名称）的营养，衰老和记忆，这是一个具有富集的表型，用于血管健康和H3T的高流行和糖尿病。建立来自其他四个项目的发现，我们将探索与环境变量的基因型相互作用，包括饮食，体育锻炼，适应和压力措施，以增加对 CVD。虽然人口规模可能很小，但慢性疾病的高流行率，例如该人群中的高血压和糖尿病以及我们在检测CVD和CVD遗传关联方面的成功风险证明了该人群对GWAS的足够力量。这项研究的发现结合了与其他四个项目中的那些vnll一起，我们可以（1）提供遗传特征的菲尔该人群的CVD；（2）从遗传与环境（饮食与生活方式）；（3）确认另外两个的潜在遗传关系人群。