LABORATORY

实验室

• 批准号: 7881857
• 负责人: Jose M. Ordovas
• 金额: $ 17.83万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7881857
• 关键词: Aging; Albumins; Behavior; Biochemical; Biological; Biological Markers; Blood; Blood specimen; C-reactive protein; Candidate Disease Gene; Cardiovascular Diseases; Carotene; Center for Translational Science Activities; Clinical; Creatinine; Elderly; Enrollment; Environment; Epinephrine; Evaluation; Excretory function; Filtration; Folate; Genetic; Glycosylated Hemoglobin; Health behavior; Heart; Home environment; Homocysteine; Homocystine; Hormones; Hydrocortisone; Inflammation; Inflammatory; Interleukin-6; Intervention; Laboratories; Life; Lipids; Measurement; Measures; Metabolic Marker; Norepinephrine; Nutritional; Nutritional status; Plasma; Process; Psychosocial Stress; Puerto Rican; Sampling; Serum; Serum Proteins; Single Nucleotide Polymorphism; Stress; Tumor Necrosis Factor-alpha; Urine; Vitamin B 12; Vitamin B6; Vitamin D; Vitamins; allostatic load; cardiovascular risk factor; cohort; diet and exercise; disability; follow-up; functional decline; genetic analysis; human TNF protein; intervention program; nutrition; programs; urinary

Biological markers are needed to capture the impact of living environment, and accumulated psychosocial stress, along v^dth effects of health behaviors, including diet and exercise on functional declines and disabilities associated with aging. The main objective of this core is to provide laboratory support to all projects. The specific aims ofthe core are to process, analjrze and interpret blood and urinary measures for each ofthe projects. The core will receive blood samples from the field staff, prepare them for analysis and distribute to appropriate labs for analysis or storage. Blood analysis of CBC, lipid profile, glycosylated hemoglobin, albumin, creatinine, C-reactive protein, and serum DHEA-S are performed. Nutritional measures include plasma vitamin (carotenes, folate, vitamin B6, vitamin B12, 25-hydroxy vitamin D) concentrations and metabolic markers (homocysteine). We will also perform genetic analysis for candidate genes in the Genetics Laboratory. Finally, we will analyze urine samples for urinary Cortisol, epinephrine and norepinephrine excretion in the Clinical and Translational Research Center (CTTRC). Each ofthe coordinated proposed projects integrates into the program at least some of these dietary, hematologic and genetic measurements. These functions will be performed for all five projects.

需要生物标记来捕捉生活环境的影响，以及积累的社会心理 压力以及健康行为的影响，包括饮食和运动对功能衰退的影响， 与衰老相关的残疾。该核心的主要目标是为所有人提供实验室支持 项目。核心的具体目标是处理、分析和解释血液和尿液测量结果 每个项目。核心将接收现场工作人员的血液样本，准备进行分析和 分发到适当的实验室进行分析或储存。 CBC、血脂、糖基化的血液分析 进行血红蛋白、白蛋白、肌酐、C 反应蛋白和血清 DHEA-S 检测。营养 措施包括血浆维生素（胡萝卜素、叶酸、维生素 B6、维生素 B12、25-羟基维生素 D） 浓度和代谢标志物（同型半胱氨酸）。我们还将对候选人进行基因分析 遗传学实验室的基因。最后，我们将分析尿液样本中的皮质醇、肾上腺素和 临床和转化研究中心 (CTTRC) 的去甲肾上腺素排泄。每一个协调的 拟议的项目至少将其中一些饮食、血液学和遗传学纳入该计划 测量。这些功能将为所有五个项目执行。