Biospecimen Shared Resource

生物样本共享资源

• 批准号: 8557664
• 负责人: ROY A. JENSEN
• 金额: $ 4.09万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-11 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8557664
• 关键词: Address; Back; Biometry; Blood; Blood specimen; Cancer Center; Cancer Center Support Grant; Clinic; Clinical; Clinical Data; Clinical Distribution; Clinical Research; Clinical Trials; Clinics and Hospitals; Collaborations; Collection; Comprehensive Cancer Center; Computerized Medical Record; Consent; Database Management Systems; Databases; Diagnostic; Drug or chemical Tissue Distribution; Enrollment; Ethics; Evaluation; Family history of; Freezing; Funding; Future; Health; Histology; Histopathology; Hospital Personnel; Hospitals; Housing; Human; Image Analysis; Immunohistochemistry; Informed Consent; Institutional Review Boards; Instruction; Intervention; Joints; Kansas; Laboratories; Leadership; Link; Malignant Neoplasms; Medical Oncologist; Medical center; Medicine; Mission; Names; Outcome; Paraffin; Participant; Pathologist; Pathology; Patient Self-Report; Patients; Peer Review; Phenotype; Play; Population; Population Heterogeneity; Postdoctoral Fellow; Preparation; Privacy; Procedures; Process; Recording of previous events; Records; Research; Research Personnel; Research Support; Resource Sharing; Role; Rural; Sampling; Security; Series; Services; Slide; Specimen; Staining method; Stains; Supervision; Surgeon; Surgical Pathology; Time; Tissue Banks; Tissue Microarray; Tissue Sample; Tissues; Training; Translational Research; Universities; Urine; Work; Writing; biobank; data management; digital; experience; improved; informatics shared resource; lifestyle factors; meetings; neoplasm registry; peripheral blood; programs; repository; sample collection; sample fixation; tissue processing

PROJECT SUMMARY (See instructions): The University of Kansas Cancer Center (KUCC) has established biospecimen banking activities to coordinate the ethical collection, storage, annotation, and distribution of tissue and peripheral blood samples to support translational research. This center-wide activity is overseen by an inter-programmatic Internal Advisory Board (I AB), under the recent supervision of Andrew K. Godwin within the Department of Pathology and Laboratory Medicine. The BSR has three major functions: 1) identify participants, administer informed consent, collect tissue, blood, and/or urine samples from selected populations, and obtain information on personal and family histories of cancer, clinical intervention, and lifestyle factors for use in research; 2) process and house human biospecimens obtained through investigator-initiated studies; and 3) provide expert histology technical procedures and pathological evaluation of tissue samples. Working in collaboration with pathologists, medical oncologists, surgeons and other hospital personnel, specially trained staff obtain patient consent, collect samples and assemble comprehensive clinical information about each donor and the corresponding samples. As part of this banking the BSR staff provides i) outstanding diagnostic pathology support; ii) a comprehensive informed consent process for the use of tissue, blood, and/or urine from patients and participants for research; iii) a specialized biospecimen bank devoted to the collection and distribution of specimens to support research; iv) extensive supporting data from the clinical record and self-reported health history of each participant, and v) fixation, paraffin processing, slide preparation and routine staining, immunohistochemistry support, tissue microarray, image analysis and digital pathology. All specimens will be linked to comprehensive clinical databases supported by the Biostatistics and Informatics Shared Resource. The BSR currently houses over 2,000 cases with fresh-frozen tissue samples and over 2,000 cases with blood samples and has access to over 28,000 surgical pathology cases on file. In 2010 the BSR served 16 (Q peer-reviewed funded) KUCC investigators across the four programs, including distribution of 382 fresh and fresh-frozen specimens, 666 units of activity to support investigator-initiated studies, and 3,105 units of histotechnology services. 47.4% of the BSR's use in 2010 was by peer-reviewed funded investigators.

项目摘要（请参阅说明）：堪萨斯大学癌症中心（KUCC）已经建立了生物测量银行活动，以协调组织和外围血液样本的道德收集，存储，注释和分布，以支持转化研究。在病理学和实验室医学系中的安德鲁·戈德温（Andrew K. BSR具有三个主要功能：1）确定参与者，管理知情同意，从选定人群中收集组织，血液和/或尿液样本，并获取有关癌症的个人和家庭历史的信息，临床干预以及研究中使用的生活方式因素； 2）通过研究者发起的研究获得的过程和容纳人类生物测量； 3）提供组织样品的专家组织学技术程序和病理评估。与病理学家，医学肿瘤学家，外科医生和其他医院工作人员合作，经过专门培训的员工获得患者同意，收集样本并收集有关每个捐助者和相应样本的综合临床信息。作为该银行业务的一部分，BSR员工提供了i）出色的诊断病理支持； ii）研究患者和参与者进行研究的全面知识同意过程； iii）专门用于收集和分发标本以支持研究的专业生物循环银行； iv）从临床记录和每个参与者的自我报告的健康病史中获得广泛的支持数据，v）固定，石蜡加工，幻灯片制备和常规染色，免疫组织化学支持，组织微阵列，图像分析和数字病理学。所有标本都将链接到由生物统计学和信息能源共享资源支持的综合临床数据库。 BSR目前拥有2,000例新鲜的组织样本和2,000例血液样本的病例，并可以使用超过28,000例手术病理病例。 2010年，BSR在这四个计划中提供了16个KUCC研究者（由Q PEER评审资助的）研究人员，包括分布382个新鲜和新鲜的标本，666个活动单位以支持研究者提出的研究和3,105个组织技术技术服务。 2010年，BSR使用的47.4％是通过同行评审的资助研究人员。