University of Kansas Cancer Center Midwest Pre-Clinical Imaging Center

堪萨斯大学癌症中心中西部临床前影像中心

• 批准号: 10795272
• 负责人: ROY A. JENSEN
• 金额: $ 800万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-08 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10795272
• 关键词: Animal Model; Animals; Basic Science; Cancer Center; Cancer Model; Clinical; Elements; Ensure; Floor; Funding; Future; Health care facility; Health system; Image; Imaging Techniques; Inpatients; Joints; Kansas; Laboratory Animals; Leadership; Longevity; Magnetic Resonance Imaging; Medical center; Midwestern United States; Modernization; Plants; Pre-Clinical Model; Process; Research; Research Activity; Research Project Grants; Techniques; Time; Translational Research; Universities; animal facility; animal imaging; aspirate; imaging capabilities; imaging facilities; mouse model; multimodality; preclinical imaging; serial imaging

Abstract The University of Kansas Medical Center seeks to build a state-of-the-art multi-modality pre-clinical imaging facility as a critical element of a campus-wide master planning process. This facility while serving the entire KUMC campus will also be an important asset for our cancer center as it seeks to expand its efforts in developing and utilizing mouse models of cancer by leveraging cutting edge experimental imaging techniques. The campus master planning effort that has taken place over the past year has focused on achieving better alignment of the capabilities of our physical plant with our basic and translational research aspirations, while simultaneously enabling the future expansion of our inpatient clinical facilities. The animal imaging facility will serve the research needs of the entire medical center campus and will be housed within the barrier of a newly constructed campus-wide vivarium that will occupy the first two floors of a planned cancer center building. This facility will be an important asset for the University and region as we seek to expand, modernize and optimize the use of animal models for preclinical translational research activities. Placement of the facility within the vivarium barrier will allow us to reduce the number of animals necessary for specific research projects by enabling serial imaging capability via a wide variety of techniques that are not possible with our current facilities. The current vivarium is approximately 50 years old, is nearing its useful lifespan, is projected to reach capacity within the next five years, cannot accommodate CT or MRI imaging, and occupies land that is needed for a critically important expansion of our inpatient health care facilities. As a result, this C06 opportunity represents an ideal time to rethink, reimagine, and renew our laboratory animal facilities and ensure that they meet the needs of KUMC in the 21st century. The proposed project is a critical element the new vivarium and in realizing the new campus master plan and will provide tenant fit-out of planned shell space on the University of Kansas Medical Center Campus. Cancer center, University, and Health System leadership have made this building their highest collective priority and ~$150 Million have been raised have been raised thus far to fund the joint facility through philanthropic efforts and three Congressionally directed spending allocations.

抽象的 堪萨斯大学医学中心致力于建立最先进的多模态临床前成像 设施作为整个校园总体规划过程的关键要素。该设施同时服务于整个 KUMC 校园也将成为我们癌症中心的重要资产，因为它致力于扩大其在以下方面的努力： 利用尖端实验成像技术开发和利用小鼠癌症模型。 过去一年进行的校园总体规划工作的重点是实现更好的目标 将我们物理工厂的能力与我们的基础和转化研究愿望保持一致，同时 同时实现我们住院临床设施的未来扩展。 动物成像设施将满足整个医学中心园区的研究需求，并将 坐落在新建的校园范围内的动物园的屏障内，该动物园将占据一个建筑的前两层 计划中的癌症中心大楼。正如我们所寻求的那样，该设施将成为大学和地区的重要资产 扩大、现代化和优化临床前转化研究活动中动物模型的使用。 将设施放置在动物园屏障内将使我们能够减少饲养所需的动物数量 通过各种技术实现串行成像功能，从而实现特定的研究项目 我们现有的设施是可能的。目前的动物园已有大约 50 年的历史，即将投入使用 寿命，预计在未来五年内达到容量，无法容纳 CT 或 MRI 成像， 并占用了我们住院医疗保健设施极其重要的扩建所需的土地。作为一个 结果，这个 C06 机会代表了重新思考、重新想象和更新我们的实验动物的理想时机 设施并确保它们满足 KUMC 21 世纪的需求。拟议的项目是一个关键 元素新的动物园和实现新的校园总体规划，并将为租户提供装修 堪萨斯大学医学中心校园的规划外壳空间。癌症中心、大学和 卫生系统领导层已将这座建筑作为他们的最高集体优先事项，并已投入约 1.5 亿美元 迄今为止，已筹集到通过慈善努力和三项国会拨款为联合设施提供资金 定向支出分配。