Biospecimen Shared Resource

生物样本共享资源

基本信息

批准号：
9120324
负责人：
ROY A. JENSEN
金额：
$ 6.29万
依托单位：
UNIVERSITY OF KANSAS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-11 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9120324
关键词：
Address Back Biometry Blood Blood specimen Cancer Center Cancer Center Support Grant Clinical Clinical Data Clinical Distribution Clinical Research Clinical Trials Clinics and Hospitals Collaborations Collection Comprehensive Cancer Center Computerized Medical Record Consent Database Management Systems Databases Diagnostic Drug or chemical Tissue Distribution Enrollment Ethics Evaluation Family history of Freezing Funding Future Health Histology Histopathology Hospital Personnel Hospitals Housing Human Image Analysis Immunohistochemistry Informed Consent Institutional Review Boards Instruction Intervention Joints Kansas Laboratories Leadership Link Malignant Neoplasms Medical Oncologist Medical center Medicine Midwestern United States Mission Names Outcome Paraffin Participant Pathologist Pathology Patient Self-Report Patients Peer Review Phenotype Play Population Population Heterogeneity Postdoctoral Fellow Preparation Privacy Procedures Process Recording of previous events Records Research Research Personnel Research Support Resource Sharing Role Rural Sampling Security Series Services Slide Specimen Staining method Stains Supervision Surgeon Surgical Pathology Time Tissue Banks Tissue Microarray Tissue Sample Tissues Training Translational Research Universities Urine Work Writing bench to bedside biobank data management digital ethnic diversity experience histotechnology improved informatics shared resource lifestyle factors meetings neoplasm registry peripheral blood programs repository sample collection sample fixation tissue processing

项目摘要

PROJECT SUMMARY (See instructions): The University of Kansas Cancer Center (KUCC) has established biospecimen banking activities to coordinate the ethical collection, storage, annotation, and distribution of tissue and peripheral blood samples to support translational research. This center-wide activity is overseen by an inter-programmatic Internal Advisory Board (I AB), under the recent supervision of Andrew K. Godwin within the Department of Pathology and Laboratory Medicine. The BSR has three major functions: 1) identify participants, administer informed consent, collect tissue, blood, and/or urine samples from selected populations, and obtain information on personal and family histories of cancer, clinical intervention, and lifestyle factors for use in research; 2) process and house human biospecimens obtained through investigator-initiated studies; and 3) provide expert histology technical procedures and pathological evaluation of tissue samples. Working in collaboration with pathologists, medical oncologists, surgeons and other hospital personnel, specially trained staff obtain patient consent, collect samples and assemble comprehensive clinical information about each donor and the corresponding samples. As part of this banking the BSR staff provides i) outstanding diagnostic pathology support; ii) a comprehensive informed consent process for the use of tissue, blood, and/or urine from patients and participants for research; iii) a specialized biospecimen bank devoted to the collection and distribution of specimens to support research; iv) extensive supporting data from the clinical record and self-reported health history of each participant, and v) fixation, paraffin processing, slide preparation and routine staining, immunohistochemistry support, tissue microarray, image analysis and digital pathology. All specimens will be linked to comprehensive clinical databases supported by the Biostatistics and Informatics Shared Resource. The BSR currently houses over 2,000 cases with fresh-frozen tissue samples and over 2,000 cases with blood samples and has access to over 28,000 surgical pathology cases on file. In 2010 the BSR served 16 (Q peer-reviewed funded) KUCC investigators across the four programs, including distribution of 382 fresh and fresh-frozen specimens, 666 units of activity to support investigator-initiated studies, and 3,105 units of histotechnology services. 47.4% of the BSR's use in 2010 was by peer-reviewed funded investigators.

项目摘要（参见说明）：堪萨斯大学癌症中心 (KUCC) 已建立生物样本库活动，以协调组织和外周血样本的道德收集、存储、注释和分发，以支持转化研究。这项中心范围内的活动由跨项目内部咨询委员会 (IAB) 监督，最近由病理学和实验医学系 Andrew K. Godwin 负责监督。 BSR 具有三个主要功能：1) 识别参与者、给予知情同意、从选定人群中收集组织、血液和/或尿液样本，并获取有关个人和家族癌症史、临床干预和生活方式因素的信息，以用于研究; 2) 处理和保存通过研究者发起的研究获得的人类生物样本； 3) 提供专家组织学技术程序和组织样本的病理学评估。经过专门培训的工作人员与病理学家、肿瘤内科医师、外科医生和其他医院人员合作，获得患者同意、收集样本并收集有关每个捐赠者和相应样本的全面临床信息。作为该银行业务的一部分，BSR 工作人员提供 i) 出色的诊断病理学支持； ii) 使用患者和参与者的组织、血液和/或尿液进行研究的全面知情同意程序； iii) 专门的生物样本库，专门收集和分发样本以支持研究； iv) 来自每个参与者的临床记录和自我报告的健康史的广泛支持数据，以及 v) 固定、石蜡处理、载玻片制备和常规染色、免疫组织化学支持、组织微阵列、图像分析和数字病理学。所有标本都将链接到由生物统计和信息学共享资源支持的综合临床数据库。 BSR 目前保存着 2,000 多例新鲜冷冻组织样本和 2,000 多例血液样本，并可查阅 28,000 多例存档的外科病理病例。 2010 年，BSR 为四个项目的 16 名（Q 同行评审资助）KUCC 研究人员提供了服务，包括分发 382 个新鲜和新鲜冷冻标本、支持研究者发起的研究的 666 个活动单位以及 3,105 个组织技术服务单位。 2010 年，47.4% 的 BSR 使用是由同行评审资助的研究人员使用的。