MIDWEST PROGENITOR CELL CONSORTIUM

中西部祖细胞联盟

• 批准号: 8358235
• 负责人: James Alexander Thomson
• 金额: $ 31.28万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358235
• 关键词: Cardiac; Cells; Cellular biology; Collaborations; Funding; Genetic Programming; Goals; Grant; Hematopoietic stem cells; Human; Minnesota; National Center for Research Resources; Pluripotent Stem Cells; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Somatic Cell; Source; Stem cells; United States National Institutes of Health; Universities; Wisconsin; cost; progenitor; programs; self-renewal

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To convert human pluripotent stem and somatic cells into hematopoietic stem cells (HSCs) and self renewing cardiac progenitor cells. The Midwest Progenitor Cell Consortium is a collaboration between the UW-Madison and the University of Minnesota, which will serve as a research hub within the NHLBI's Progenitor Cell Biology Consortium. The goal is to develop new strategies to convert human pluripotent stem and somatic cells into hematopoietic stem cells (HSCs) and self renewing cardiac progenitor cells through identification of genetic program leading to formation of pre-HSCs and cardiac progenitors and activation of self-renewal program in lineage restricted cells. This project uses WNPRC Stem Cell Resources.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 目的：将人多能干和体细胞转化为造血干细胞（HSC）和自我更新心脏祖细胞。 中西部祖细胞联盟是UW-Madison和明尼苏达大学之间的合作，该公司将在NHLBI的祖细胞生物学财团内充当研究中心。目的是制定新的策略，通过鉴定遗传程序，从而形成前HSC和心脏祖细胞，以及在谱系受限细胞中的自我更新计划的激活，将人类多能干和体细胞转化为造血干细胞（HSC）和自我更新心脏祖细胞。 该项目使用WNPRC干细胞资源。