INFANT PRIMATE RESEARCH LABORATORY

婴儿灵长类动物研究实验室

• 批准号: 8357623
• 负责人: Thomas M Burbacher
• 金额: $ 15.66万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357623
• 关键词: Animals; Auditory Brainstem Responses; Autistic Disorder; Behavior; Childhood; Consultations; Data; Data Collection; Development; Disease Outbreaks; Electroencephalography; Elevator; Equipment; Face; Floor; Funding; Grant; Health; Housing; Human; Infant; Infant Food; Infant formula; Journals; Laboratories; Laboratory Research; Learning; Maintenance; Memory; Methods; Modeling; Monkeys; National Center for Research Resources; Pattern; Pregnancy; Primates; Principal Investigator; Procedures; Protocols documentation; Regulation; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Safety; Services; Site; Smooth Pursuit; Source; Stem Cell Research; Stimulus; Students; Supervision; System; Testing; Time; Touch sensation; Training; Translational Research; United States National Institutes of Health; Virus; Work; abstracting; biobehavior; computerized; cost; environmental enrichment for laboratory animals; food preparation; improved; infancy; interest; meetings; neurobehavioral; primate development; programs; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. During the past grant year, laboratory staff continued to provide vital support to on-going research projects. Services included consultation, training, on-site supervision, equipment maintenance and development, normative and experimental data collection and data summary and analysis. During the last year, the renovation of the lab was successfully completed. The 12 million dollar renovated lab includes an internal elevator connecting the 2 floors of the IPRL for the first time, a new cage washer, a state-of-the-art kitchen for infant formula and food preparation, smaller animal rooms to better control disease outbreaks, new playrooms, and specialized rooms for virus studies. A new locker room and bathrooms and showers for IPRL staff were included in the renovation. In addition to improving safety for both monkeys and human handlers, the physical facilities also meet current and anticipated regulations regarding environmental enrichment for laboratory-housed monkeys. During 2010, we made further advances in the development of biobehavioral assessment protocols. These include1) our touch-sensitive computerized testing system for the assessment of learning and memory, 2) protocols to actively collect optokinetic and smooth pursuit eye movement data, 3) methods to evaluate the auditory brainstem response and 4) procedures to study EEG responses to a variety of stimuli (faces, abstract patterns) in autism-related work. All procedures are noninvasive, modeled from human infancy work and provide the opportunity to make strong advances in pediatric health research. In addition, we continue to work with a myriad of investigators to provide healthy, gestation-known infants for projects conducted in the lab. We also continue to serve as a national resource for laboratories and federal agencies interested in stem cell research and infant neurobehavioral development. Our popular student research program is now fully operational with plans to include a monthly journal club on Primate Development and Behavior (including topics on primate translational research).

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 在过去的一年中，实验室人员继续为正在进行的研究项目提供重要的支持。 服务包括咨询，培训，现场监督，设备维护和开发，规范和实验数据收集以及数据摘要和分析。 在过去的一年中，实验室的翻新成功完成了。 经过翻新的1200万美元的实验室包括第一次连接IPRL的2层的内部电梯，新的笼子洗衣机，一个用于婴儿配方奶粉和食物准备的最先进的厨房，较小的动物室以更好地控制疾病爆发，新的游戏室和病毒研究的专业室。装修中包括一个新的更衣室，浴室和淋浴。除了改善猴子和人类处理人员的安全性外，物理设施还符合有关实验室猴子环境丰富的当前和预期的法规。 在2010年，我们在生物行为评估方案的发展方面取得了进一步的进步。 其中包括1）我们的触摸敏感计算机测试系统，用于评估学习和记忆，2）协议，以积极收集光学动力学和光滑的追捕眼动动作数据，3）评估听觉脑干响应的方法，以及4）研究EEG对EEG响应的过程自闭症相关工作中的各种刺激（面部，抽象模式）。 所有程序都是无创的，以人类婴儿期的工作为基础，并提供了在小儿健康研究方面取得强大进步的机会。 此外，我们继续与无数的调查人员合作，为在实验室中进行的项目提供健康的妊娠婴儿。 我们还将继续作为对干细胞研究和婴儿神经行为发展感兴趣的实验室和联邦机构的国家资源。 我们受欢迎的学生研究计划现在正在全面运作，计划包括一个每月关于灵长类动物发展和行为的期刊俱乐部（包括关于灵长类动物转化研究的主题）。