False positive newborn hearing screening results and autism spectrum disorder

新生儿听力筛查结果假阳性与自闭症谱系障碍

基本信息

批准号：
10296153
负责人：
Nicole Talge
金额：
$ 32.82万
依托单位：
MICHIGAN STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10296153
关键词：
Age Age-Months Attention deficit hyperactivity disorder Auditory Brainstem Responses Auditory Perception Base of the Brain Behavior Behavioral Symptoms Biodiversity Biological Markers Biological Process Birth Certificates Brain Brain Stem CNS processing Cephalic Child Cochlea Data Data Set Databases Detection Development Diagnosis Diagnostic Disease Electrophysiology (science)Enrollment Epigenetic Process Epilepsy Esthesia Etiology Exhibits Failure Family Future Genetic Hearing Heterogeneity Hospitals Immune Individual Infant Intellectual functioning disability Intervention Lead Link Magnetic Resonance Imaging Measurable Medicaid Medical Metabolic Michigan Morphology Neonatal Screening Neurodevelopmental Disorder Newborn Infant Pathway interactions Perinatal Premature Birth Premature Infant Process Public Health Recording of previous events Records Research Risk Risk Assessment Risk Factors Sampling Screening Result Siblings Structure Subgroup Symptoms Target Populations Time Treatment Efficacy Ultrasonography United States United States Dept. of Health and Human Services administrative database auditory processing autism onset autism spectrum disorder autistic children base comorbidity disorder risk follow-up health administration hearing impairment hearing screening improved indexing infancy interest male perinatal brain perinatal health population based postnatal postnatal period predictive marker prenatal prospective response risk prediction screening screening program sex sociodemographics stem

项目摘要

Abstract Biomarkers have garnered great interest in the study of autism spectrum disorder (ASD) due to their potential to inform etiology as well as diagnostic risk prediction. Despite the diversity of biological processes implicated in ASD (epigenetic, metabolic, immune), final common pathways involve disruptions to prenatal and/or early postnatal brain development. As a result, brain-based biomarkers – particularly those that can be assessed during early infancy -- hold unique potential in advancing our understanding of the disorder. To this end, auditory brainstem responses (ABRs) may be a biomarker worth further consideration. ABRs exhibit strong cross-sectional associations with ASD, can be non-invasively and reliably assessed in young infants, and are a common target of population-based newborn hearing screening programs. However, it remains unclear whether ABR alterations precede the onset of ASD symptoms, are confounded by or interact with known ASD risk factors (e.g., family history, perinatal risk), or generalize to other neurodevelopmental disorders (e.g., attention deficit hyperactivity disorder). The objective of this proposal is to evaluate whether false positive, ABR-based newborn hearing screening results (i.e., failure in the absence of hearing loss) are prospectively associated with ASD. To do this, we will combine and analyze Michigan Department of Health and Human Services (MDHHS) datasets from 2004- 2020: newborn hearing screening records, birth certificates, and Medicaid claims. As part of this effort, we will evaluate whether findings differ according to known ASD risk factors (male sex; preterm delivery; sibling ASD diagnosis) and comorbidities (intellectual disability; epilepsy). We will also examine whether false positive newborn hearing screening findings are associated with attention deficit hyperactivity disorder (ADHD) – a neurodevelopmental disorder that, like ASD, is linked to perinatal etiologies as well as ABR alterations. Findings from this rigorous and well-powered population-based analysis have the potential to launch multiple lines of research that may lead to breakthroughs in our understanding of and surveillance for ASD.

抽象的由于潜力告知病因以及诊断风险预测。在ASD（表观遗传学，代谢，免疫）中，最终的共同途径涉及产前和 /或早期的中断结果，大脑后，可以评估的基于大脑的生物标志物在婴儿早期期间 - 具有促进我们对疾病的理解的独特潜力。艾伯。与ASD表现出强大的交叉交流婴儿，是基于人群的新生儿听力筛查计划的共同目标。尚不清楚在ASD症状的发作之前，是否被混淆或相互作用具有已知的ASD风险因素（例如家族史，围产期风险）或推广到其他神经发育障碍（例如注意力缺陷多动障碍）。该提案的目的是评估误报，基于ABR的新生儿听力筛查是否结果（即在没有听力损失的情况下失败）与ASD相关。从2004年组合和分析密歇根州卫生与公共服务部（MDHHS）数据集 2020年：新生儿筛查记录，出生证明和医疗补助索赔。评估发现是否根据已知的ASD风险因素（男性）有所不同诊断）和合并症新生儿听力筛查结果与达到缺陷多动障碍（ADHD）有关像ASD一样，神经发育障碍与围产期依ilololololatis有关。严格且基于人口的严格分析的发现有可能推出多个可能会导致我们对ASD的理解和监视的突破性研究。