Animal Behavior Core

动物行为核心

基本信息

批准号：
10224300
负责人：
Thomas M Burbacher
金额：
$ 17.65万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-28 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10224300
关键词：
Animal Behavior Animal Model Area Behavior Behavior assessment Behavioral Research Biological Models Brain imaging Budgets Calcium Signaling Characteristics Child Child Development Clinical Cognitive Consultations Counseling Data Development Ensure Environmental Exposure Equipment Experimental Designs Fiber Gene-Modified Genes Genetic Grant Infrastructure Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Intervention Knowledge Laboratories Methods Mission Modeling Motor Neurosciences Operative Surgical Procedures Pharmaceutical Preparations Photometry Primates Protocols documentation Publications Rattus Regulation Research Research Institute Research Personnel Research Project Grants Research Training Resources Rodent Rodent Model Sensory Services Students Study models Techniques Technology Testing Training Translational Research Universities Update Washington Work animal care animal imaging base behavior test brain behavior brain research clinical application clinical development cost cost effective cost estimate data management environmental chemical functional outcomes in vivo innovation insight nonhuman primate novel optogenetics prevent programs relating to nervous system response social tool

项目摘要

PROJECT SUMMARY – ANIMAL BEHAVIOR CORE The Animal Behavior Core (ABC) provides an infrastructure for investigators to perform the most advanced and innovative functional assessments in rodent models to assist in understanding the origins and treatment of intellectual and developmental disabilities (IDD). The ABC supports efforts aimed at developing and characterizing novel rodent models of IDD that result from gene identification or gene modification research or environmental exposure studies performed by IDDRC Research Affiliates. Furthermore, the ABC is critical as IDDRC investigators evaluate the functional outcomes of intrinsic (gene-based) and/or extrinsic (surgical, environmental, chemical, or drug-based) interventions. Specific Aims of the ABC are: 1. Provide scientific, management, and budgeting services to Research Affiliates using animal models for studies of IDD; 2. Provide behavioral testing equipment, research space, and novel testing protocols for investigators that enable state-of-the-art assessment of behavior in rodent models of IDD; 3. Train Research Affiliates and their staff in appropriate testing protocols; 4. Coordinate services across other IDDRC Cores and support development of clinical applications; and 5. Promote the development of additional innovative techniques that can be utilized in conjunction with assessments of behavioral functions in rodent models of IDD.

项目摘要——动物行为核心动物行为核心 (ABC) 为研究人员提供了一个基础设施，使其能够发挥最大作用对啮齿动物模型进行先进和创新的功能评估，以帮助了解起源和 ABC 支持旨在发展智力和发育障碍的努力。并表征由基因鉴定或基因修饰研究产生的新型 IDD 啮齿动物模型或 IDDRC 研究附属机构进行的环境暴露研究此外，ABC 也至关重要。 IDDRC 研究人员评估内在（基于基因）和/或外在（手术、 ABC 的具体目标是： 1. 提供科学的、基于环境的、化学的或基于药物的干预措施。为使用动物模型研究 IDD 的研究附属机构提供管理和预算服务； 2. 为研究人员提供行为测试设备、研究空间和新颖的测试方案 3. 培训研究附属机构及其 4. 协调其他 IDDRC 核心的服务和支持临床应用的开发；以及 5. 促进其他创新技术的开发可以与 IDD 啮齿动物模型的行为功能评估结合使用。