Mechanisms and Markers of Prostate Cancer Metastases

前列腺癌转移的机制和标志物

• 批准号: 8120394
• 负责人: ROBERT Louis VESSELLA
• 金额: $ 212.73万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8120394
• 关键词: Mechanisms; Markers; Prostate; Cancer; Metastases

DESCRIPTION (provided by applicant): In this renewal resubmission, we. propose to continue studies on prostate cancer (CaP) metastasis, especially focusing on the dissemination and growth of CaP in bone. This effort has coordinated much previous work from a variety of sources within the University of Washington (UW) milieu and is multidisciplinary, incorporating cancer and bone biology, cancer endocrinology, pathology and genomics. Institutional partners include the Fred Hutchinson Cancer Research Center and the UW Institute of Stem Cell Sciences. Inquiries into the mechanisms of CaP bone metastasis, are poorly studied, in part because of a lack of appropriate animal models and specimens. As the Progress Reports will demonstrate, these limitations have been largely overcome by our investigators, and the derived resources will enable the pursuit of the scientific objectives proposed. This P01 consists of 3 projects and 2 cores. Project 1 is entitled "The Detection, Isolation and Characterization of Disseminated Tumor Cells". This project will genomically characterize the DTC, looking at correlates to progression and biological function. It incorporates multiple studies exploring the stem cell aspects of DTC and the role of DTC in tumor dormancy. This is a new project, led by Dr. Robert Vessella that replaces the previous Project 1. Project 2 is entitled "Transmembrane Proteases and Prostate Carcinogenesis". This project, led by Dr. Pete Nelson, will focus heavily on the serine protease TMPRSS2 and the gene fusion TMPRSS2-ERG. Project 3 is entitled: "Determinants of Response to Type 1 Insulin-like Growth Factor Inhibition in Prostate Cancer". This project is led by Dr. Steve Plymate and is highly translational as it is focused on better understanding the role of IGF-1R as clinical trials at UW and elsewhere are being conducted to target this receptor. Projects 2 and 3 are continuations of very successful studies during the current funding period. Core A is the Biospecimen Core which acquires processes and distributes biospecimens. It also conducts pre-clinical xenograft studies and provides statistical support to the overall P01 program. Core B is the Administrative Core which provides overall administrative support to the investigators.

描述（由申请人提供）：在此续签重新提交中，我们。建议继续研究前列腺癌（CAP）转移，尤其是专注于骨骼中帽的传播和生长。这项工作已经协调了华盛顿大学（UW）环境中各种来源的许多工作，并且是多学科的，结合了癌症和骨骼生物学，癌症内分泌，病理学和基因组学。机构伙伴包括弗雷德·哈钦森癌症研究中心和大学干细胞科学研究所。对帽骨转移机制的调查，研究很少，部分原因是缺乏适当的动物模型和标本。正如进度报告所表明的那样，这些局限性在很大程度上被我们的调查人员克服了，而派生的资源将使提出的科学目标追求。该P01由3个项目和2个核心组成。项目1的标题为“检测，隔离和表征的传播肿瘤细胞”。该项目将在基因组中表征DTC，研究与进展和生物功能相关。它结合了探索DTC干细胞方面的多项研究以及DTC在肿瘤休眠中的作用。这是一个由Robert Consella博士领导的新项目，取代了先前的项目1。项目2的标题为“跨膜蛋白酶和前列腺癌发生”。由皮特·尼尔森（Pete Nelson）博士领导的该项目将重点关注丝氨酸蛋白酶TMPRSS2和Gene Fusion TMPRSS2-ERG。项目3的标题为：“对1型胰岛素样生长因子抑制的反应决定因素”。该项目由史蒂夫·普莱曼（Steve Plymate）博士领导，并且高度转化，因为它专注于更好地理解IGF-1R作为UW和其他地方的临床试验的作用，以瞄准该受体。项目2和3是在当前资助期间非常成功的研究的延续。核心A是获取过程并分布生物测量的生物晶体核心。它还进行了临床前异种移植研究，并为整个P01计划提供统计支持。核心B是为调查人员提供总体行政支持的行政核心。