Tissue and Specimen Core

组织和样本核心

基本信息

批准号：
7314946
负责人：
ROBERT Louis VESSELLA
金额：
$ 31.22万
依托单位：
FRED HUTCHINSON CANCER RESEARCH CENTER
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-01 至 2012-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7314946
关键词：
Address African American Aliquot Androgen Receptor Antibodies Aspirate substance Autopsy Biological Biological Assay Biological Markers Biological Models Biological Preservation Biopsy Bone Marrow Cancer Research Project Cells Cellular Structures Censuses Clinic Clinical Clinical Data Clinical Research Clinical Trials Collaborations Communication Complementary DNA Computer software Confidentiality Confidentiality of Patient Information Consent Country DNA Daily Data Databases Development Dimensions Enrollment Ensure Epidemiology Epithelial Exercise Facility Construction Funding Category Foundations Fred Hutchinson Cancer Research Center Freezing Frozen Sections Funding Future Gel Gel Chromatography Gender Gene Expression Generations Genes Gleason Grade for Prostate Cancer Glycoproteins Goals Grant Health Insurance Portability and Accountability Act Histologic Housing Human Resources Image Immunoassay Immunohistochemistry In Situ Hybridization Individual Industry Information Dissemination Institutes LNCaP Laboratories Lasers Leadership Link Liquid substance Location Lymphocyte Maintenance Malignant neoplasm of prostate Marrow Metastatic Neoplasm to the Bone Methodology Methods Minority Monitor Mus Neoadjuvant Therapy Online Systems Operative Surgical Procedures Pathologic Pathologist Patients Performance Peripheral Blood Lymphocyte Personal Satisfaction Phenotype Pilot Projects Plasma Polymerase Chain Reaction Predictive Value Principal Investigator Process Program Development Progress Reports Prostate Prostate specific antigen measurement Protocols documentation Quality Control RNA RNA Degradation RNA, Ribosomal, 18S Radical Prostatectomy Range Records Recurrence Reproduction spores Research Research Ethics Committees Research Infrastructure Research Personnel Resource Sharing Resources Reverse Transcriptase Polymerase Chain Reaction Sampling Sepharose Serial Passage Series Serum Services Side Slide Sorting - Cell Movement Specimen Specimen Handling Staging Staining method Stains Standards of Weights and Measures Stem cells System Techniques Tissue Microarray Tissue Sample Tissues Training Translating Translational Research Tumor Tissue United States National Institutes of Health Work Xenograft Model Xenograft procedure abstracting base cDNA Expression clinical application cost cost effectiveness crosslink design experience germ free condition human tissue immunoreactivity improved interest laser capture microdissection neoplastic cell novel p27 Cell Cycle Protein p27 Enzyme Inhibitor peripheral blood preclinical study prognostic programs quality assurance repository research and development research study sample collection serum PSA time interval tissue culture tool tumor urologic user-friendly

项目摘要

The Specimen Core provides part of the infrastructure support for Projects 1 - 5 as well as for future pilot and developmental projects. It has been designed to meet the needs of these projects plus serve as a stand- alone resource for collaborative efforts with other SPOREs. This Core will provide a well-organized and standardized system of specimen collection, storage, distribution and related clinical/research information dissemination that is based on over two decades of experience. There will be consistency and quality assurance in the pathological analysis of tissue specimens. Furthermore, the centralized management of the specimens will facilitate their distribution based upon the priorities defined by a panel of investigators familiar with all of our SPORE research endeavors. The operations of this Core group into 5 components: 1. Specimen acquisition, processing, quality control, storage and accessioning into databases. 2. A development program to continually improve the quality and efficiency with which we obtain tissue samples and derivative products. 3. A prostate cancer xenograft maintenance, development and study program. 4. Laboratory services, including interpretation of tissues and tissue localization studies by a urologic pathologist, immunohistochemistry (IHC), quantitative RT-PCR, and immunoassays, i.e. PSA, and tissue culture. The Core will also perform pre-clinical studies using our xenograft resources, and 5. An administrative program to obtain samples from minority patients, prioritize the distribution of specimens, conduct a quality control program, ensure patient confidentiality and compliance with IRB requirements, and to interact with other prostate SPOREs. The performance of translational research mandates that investigators have ready access to well documented clinical specimens and relevant biological models. The investigators directing the Biospecimen Core have decades of experience in recognizing these needs and providing such services not only to local investigators but to those who request specimens on a world-wide basis. For example, samples of specimens from our rapid autopsy program (e.g. prostate cancer bone metastases) and our LuCaP series of prostate cancer xenografts have been distributed internationally. In this renewal, such interactions with our own SPORE investigators, those collaborations with other SPORE investigators and collaborations with non- SPORE investigators will be a high priority. This will truly enhance the translational aspects of the NW Prostate Cancer SPORE.

标本核心提供了针对项目1-5的基础设施支持以及未来的飞行员和发展项目。它旨在满足这些项目的需求，并作为独立仅与其他孢子进行协作的资源。该核心将提供一个井井有条的标本收集，存储，分布和相关临床/研究信息的标准化系统基于超过二十年的经验的传播。会有一致性和质量在组织标本的病理分析中保证。此外，集中管理标本将根据研究人员的定义的优先级来促进其分布熟悉我们所有的孢子研究工作。该核心组的操作分为5个组成部分： 1。采集，处理，质量控制，存储和登录到数据库中。 2。开发计划，以不断提高我们获得组织的质量和效率样品和衍生产品。 3。前列腺癌异种移植，发展和研究计划。 4。实验室服务，包括通过泌尿科对组织和组织定位研究的解释病理学家，免疫组织化学（IHC），定量RT-PCR和免疫测定，即PSA和组织培养。核心还将使用我们的异种移植资源进行临床前研究，并 5。一项行政计划，以获取少数族裔患者的样本，优先分配标本，进行质量控制计划，确保患者机密性和遵守IRB 要求，并与其他前列腺孢子互动。翻译研究的表现要求调查人员可以准备好井井有条记录了临床标本和相关的生物学模型。指导生物循环的调查人员核心在识别这些需求并提供此类服务不仅为本地提供了数十年的经验调查人员，但对那些在世界范围内要求标本的人。例如，样本我们快速尸检计划（例如前列腺癌骨转移）和Lucap系列的标本前列腺癌异种移植物已在国际上分布。在这种续约中，这种与我们的互动自己的孢子调查员，与其他孢子调查员的合作以及与非孢子的合作孢子调查人员将是一个很高的优先事项。这将真正增强西北的翻译方面前列腺癌孢子。