CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH

CTSA 儿科研究基础设施

• 批准号: 8173833
• 负责人: Barry Coller
• 金额: $ 41.46万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173833
• 关键词: Education; Pediatric Research; Research Infrastructure

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Rockefeller University Hospital, a GCRC awardee since 1963, has been the continuous "home" for clinical and translational science at Rockefeller since 1910. It has been the site of numerous landmark scientific and clinical contributions, and many of its trainees have gone on to become academic leaders. With the new resources available under a Clinical and Translational Science Award (CTSA), a core faculty of. distinguished investigators, whose research spans the basic-translational spectrum and encompasses a broad range of scientific and medical disciplines, will integrate and expand their scientific and educational programs in a new Rockefeller University Center for Clinical and Translational Science. The new Center will transform clinical and translational research by encouraging new studies, and by enhancing and centralizing the support structures required to conduct studies with scientific rigor and an absolute commitment to protection of human subjects and participant safety. The key elements in the transformation will be: 1) A new governance structure reflecting the NIH cooperative agreement (U54) "assistance" mechanism, 2) Creation of a new K-12 Clinical Research Scholars Program offering Masters and PhD level degrees to complement the current Clinical Scholars,Program, 3) Infrastructure enhancements to facilitate the development and conduct of clinical protocols under the principle of Good Clinical Practice (GCP), including biomedical informatics, biostatistics. bionutrition, research nursing, research pharmacy, participant recruitment and community engagement, and regulatory support and oversight from the clinical research (research subject advocate) support office, 4) Development of innovative and novel core methodologies related to dendritic cell therapy; hepatitis C, and malignancies; genetics/genomics; assessing the immune response; and metabolic phenotyping. The Center will continue Rockefeller's tradition of focusing on the interface between scientific discovery, human pathophysiology, and novel diagnostic, preventive and therapeutic strategies. It will partner with industry, when mutually beneficial, to achieve these goals. The Center will also be an active member of the National CTSA Consortium, offering the Consortium novel ideas and tools for conducting and evaluating clinical and translational research. It will also eagerly adopt the best practices identified by the Consortium and adhere to the standards set by the Consortium.

该子项目代表了 CTSA 资金百分比的估计 被用于广泛的研究领域（艾滋病研究、儿科研究或 临床试验）。 列出的总成本只是 CTSA 金额的估计值 该研究领域的基础设施，而不是直接资助 NCRR 向子项目或子项目人员提供的补助金。 洛克菲勒大学医院自 1963 年以来一直是 GCRC 获奖者，自 1910 年以来一直是洛克菲勒临床和转化科学的“家”。它是众多具有里程碑意义的科学和临床贡献的场所，许多受训者都继续在成为学术带头人。和 临床和转化科学奖 (CTSA) 提供的新资源是该奖的核心院系。 杰出的研究人员的研究跨越基础翻译领域并涵盖广泛的科学和医学学科，他们将整合和扩展他们的科学和教育 洛克菲勒大学新的临床和转化科学中心的课程。新中心将通过鼓励新研究、加强和集中以科学严谨和绝对承诺开展研究所需的支持结构来改变临床和转化研究。 保护人类受试者和参与者的安全。转型的关键要素将是：1）反映 NIH 合作协议（U54）“援助”机制的新治理结构，2）创建新的 K-12 临床研究学者计划，提供硕士和博士学位水平学位作为补充 当前的临床学者计划，3）增强基础设施，以促进根据良好临床实践（GCP）原则制定和实施临床方案，包括生物医学信息学、生物统计学。生物营养、研究护理、研究药学、参与者招募和社区参与以及临床研究的监管支持和监督（研究主题 倡导者）支持办公室，4）开发与树突状细胞治疗相关的创新和新颖的核心方法；丙型肝炎和恶性肿瘤；遗传学/基因组学；评估免疫反应；和代谢表型。该中心将延续洛克菲勒的传统，专注于 科学发现、人类病理生理学以及新的诊断、预防和治疗策略之间的联系。它将与业界合作，在互惠互利的情况下实现这些目标。该中心还将成为国家 CTSA 联盟的积极成员，为联盟提供新颖的想法 以及进行和评估临床和转化研究的工具。它还将积极采用联盟确定的最佳实践，并遵守联盟制定的标准。