Neonatal Research Network: the Lurie Children's - Northwestern University Study Center

新生儿研究网络：卢里儿童 - 西北大学研究中心

基本信息

批准号：
10682322
负责人：
AARON HAMVAS
金额：
$ 33.12万
依托单位：
LURIE CHILDREN'S HOSPITAL OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-01 至 2030-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10682322
关键词：
Address Admission activity Advocacy Basic Science Beds Biological Factors Birth Chicago Child Child health equity Childhood Clinical Clinical Research Clinical Trials Collaborations Collection Communities Complex Data Data Coordinating Center Development Discipline of obstetrics Disease Disparity Early Diagnosis Education Environmental Exposure Equity Ethnic Origin Genetic Geography Goals Growth Health Hospitals Infant Infant Mortality Institution Intervention Investigation Knowledge Lead Maternal Mortality Maternal-Fetal Medicine Units Network Maternal-fetal medicine Medical center Metabolic Minority Groups Mothers Multi-Institutional Clinical Trial Multicenter Neonatal Research Network National Institute of Child Health and Human Development Neighborhoods Neonatal Neonatology Newborn Infant Obesity Observational Study Outcome Overweight Participant Patient Recruitments Pediatric Hospitals Perinatal Physicians Population Heterogeneity Positioning Attribute Pregnancy Outcome Pregnant Women Premature Birth Procedures Process Protocols documentation Provider Race Records Reduce health disparities Refractory Research Research Infrastructure Research Institute Research Personnel Research Support Resources Scientist Site Therapeutic Training United States Universities Woman adverse maternal outcomes clinical care clinical center fetal programming follow-up health equity health equity promotion high risk improved in utero infancy infant outcome maternal stress medical schools medically underserved member mother nutrition neonatal outcome next generation novel nutrition organizational structure outcome disparities participant retention pediatric department postnatal premature prenatal recruit retention rate service delivery social factors success

项目摘要

PROJECT SUMMARY Improving neonatal outcomes and addressing outcome disparities for mothers and their infants require national centers with excellence in clinical care and research that partner with communities to address these challenges equitably. The existence of these disparities based on race and ethnicity, specifically in maternal and infant mortality and preterm birth, highlight the complex prenatal and postnatal social and biological factors that influence pregnancy outcomes. The NICHD Neonatal Research Network (NRN), by creating a geographically diverse multi-institutional research infrastructure, has an ongoing commitment to improving health outcomes and reducing known disparities in infants born preterm and in other high-risk situations. The Lurie Children’s - Northwestern University Study Center, comprised of the Division of Neonatology at the Ann & Robert H. Lurie Children’s Hospital of Chicago and the Department of Pediatrics at Northwestern University Feinberg School of Medicine, is anchored by 12,000 deliveries per year and 1700 admissions per year to our 148 NICU beds at Lurie Children’s Hospital and Prentice Women’s Hospital and our collaboration with our partners at the Northwestern Maternal-Fetal Medicine Units (MFMU) Study Center. We have a long-standing tradition of clinical excellence, investigator-initiated and multi-center investigation, a commitment to train the next generation of physician scientists, and advocacy to promote health equity. Thus, we are well-positioned to be a strong addition as a Clinical Center to the NRN. To achieve the goals of the NRN, the Lurie Children’s-Northwestern Study Center will: 1) capitalize on the existing synergistic relationships within the Lurie Children’s / Northwestern Medical Center and underserved neighborhoods of Chicago to “facilitate greater involvement of diverse populations” and promote recruitment of pregnant women and their newborns for study protocols and facilitate their retention through the follow-up period; 2) propose and participate in novel clinical studies and analyses that capitalize on unique resources at the Lurie Children’s-Northwestern site; 3) utilize our site’s effective organizational structure and management approach to support the objectives of the NRN; 4) establish and implement high-quality data and biospecimen collection processes that meet the requirements and standards of the NRN based on our current success with these processes; and 5) contribute to the scientific collaboration among the NICHD, the NRN and MFMU clinical centers, and the Data Coordinating Center to support the research networks’ objectives.

项目概要改善新生儿结局并解决母亲及其婴儿的结局差异需要具有卓越临床护理和研究能力的国家中心与社区合作解决这些挑战的存在基于种族和族裔，特别是在种族和族裔方面。孕产妇和婴儿死亡率和早产，凸显了复杂的产前和产后社会和生物学问题 NICHD 新生儿研究网络 (NRN) 通过创建一个地理上多样化的多机构研究基础设施，持续致力于改善健康结局并减少早产儿和其他高风险情况下的已知差异。儿童 - 西北大学研究中心，由 Ann & Robert 新生儿科组成芝加哥 H. Lurie 儿童医院和西北大学 Feinberg 儿科医学院每年接生 12,000 例，148 个新生儿重症监护病房 (NICU) 每年接待 1700 名新生儿 Lurie 儿童医院和 Prentice 妇女医院的床位以及我们与合作伙伴的合作西北母胎医学中心 (MFMU) 研究中心拥有悠久的临床传统。卓越、研究者发起和多中心调查、致力于培养下一代因此，我们有能力成为一个强大的补充。作为 NRN 的临床中心为了实现 NRN 的目标，卢里儿童西北研究。中心将： 1) 利用卢里儿童医院/西北大学现有的协同关系医疗中心和芝加哥服务不足的社区“促进多元化的更多参与” 人口”并促进招募孕妇及其新生儿进行研究方案并促进他们在随访期间的保留；2）提出并参与新的临床研究和分析：利用 Lurie Children's-Northwestern 网站的独特资源 3) 利用我们网站的有效性；支持 NRN 目标的组织结构和管理方法； 4) 建立和实施符合要求和标准的高质量数据和生物样本采集流程 NRN 基于我们目前在这些过程中取得的成功；5) 为科学合作做出贡献； NICHD、NRN 和 MFMU 临床中心以及数据协调中心之间的合作，以支持研究网络的目标。