Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success

开发、展示和传播创新项目以实现转化成功

基本信息

批准号：
9310443
负责人：
Barry Coller
金额：
$ 515.14万
依托单位：
ROCKEFELLER UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-05 至 2021-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9310443
关键词：
Adopted Back Cessation of life Clinical Clinical Nursing Research Clinical Research Clinical Sciences Communities Conceptions Data Databases Diagnosis Electronic Health Record Funding Genome Health Health Policy Hospitals Human Human Resources Human Subject Research Individual Institutes Knowledge Leadership Learning Methods Multicenter Studies NCI Scholars Program New York Ontology Outcome Participant Perception Performance Pharmaceutical Preparations Phase Phenotype Population Prevention Protocols documentation Public Health Recruitment Activity Research Research Personnel Resources Science Scientist Series Structure Testing Training Translating Translational Research United States National Institutes of Health Universities Vision design experience human disease improved informatics infrastructure innovation instrument member novel outreach programs repository skills success therapeutic development volunteer

项目摘要

Contact PD/PI: Coller, Barry The overall vision of the Rockefeller University Center for Clinical and Translational Science (CCTS), supported by the CTSA program, is to develop, demonstrate, and disseminate innovative programs to achieve translational success and to integrate these into a seamless “Learning Clinical Research Enterprise” that uses outcome data to drive quality improvement for the benefit of human health. To achieve this vision we will enhance our existing programs and add new ones. Specific aims: 1. To integrate our existing and new programs into a Translational Research Navigation (TRN) Program that encourages, facilitates, and insures the integrity of all human subjects research from conception to conclusion, and that will expedite our participation in the CTSA network of multi-center studies. 2. To integrate our existing and new programs into a Translational Workforce Educational Program that insures that all members of the translational workforce have the knowledge and skills required for them to perform their functions individually and as members of diverse scientific teams. 3. To integrate our existing and new programs into a From Discovery to Health- Enhancing Product Program to insure that investigators have the resources to maximize the likelihood that they can translate their novel discoveries into products that improve human health. To achieve this vision, we will: 1. Integrate our Community Engaged Navigation, Protocol Navigation, Research Participant Engagement in Protocol Priorities and Design, Basic Scientist Outreach, Mutually Aligned Community Engaged/ Mechanistic Science, Centralized Recruitment and Research Volunteer Repository, Ontology-Backed Phenotyping, and Research Participant Perception programs with a new Protocol Implementation Navigation program into an overarching TRN program under a new administrative structure with senior leadership. TRN will be supported by an integrated Informatics infrastructure adopting best practices and NIH and CTSA data standards. TRN will support both local protocols and CTSA network protocols with TRN leadership serving on the Liaisons to the Trial and Recruitment Innovation Centers. 2. Integrate our extensive current educational programs, including the KL2 Clinical Scholars program, with new educational initiatives to: prepare community clinicians to participate in research teams, enhance Clinical Research Nursing training, provide a full range of educational experiences in translating scientific discoveries into health-enhancing products, develop ontology-backed phenotyping instruments, and query large electronic health record databases to test scientific hypotheses at the population level. 3. Integrate the new Tri-Institutional Therapeutic Development Institute, which provides access to medicinal chemists and drug project management, with the CCTS Pilot program, the Rockefeller scientific resource centers, the New York Genome Center, the new Robertson Therapeutic Development Fund, the TRN program, and the CCTS Hospital to enable investigators to traverse the Valley of Death through Phase 1/2 studies. Outcome metrics will drive performance improvement throughout. Project Summary/Abstract Page 248 Contact PD/PI: Coller, Barry The Rockefeller University Center for Clinical and Translational Science is dedicated to improving human health by providing resources and personnel to support the conduct of the highest quality research to improve the prevention, diagnosis, and treatment of human disease, as well as to inform and implement public health policy. It will also produce novel methods to improve both the scientific information obtained in the studies and the way in which the research is performed.

联系人 PD/PI：Coller, Barry 洛克菲勒大学临床与转化科学中心（CCTS）的总体愿景，在 CTSA 计划的支持下，旨在开发、展示和传播创新计划，以实现转化成功并将其整合到一个无缝的“学习临床研究企业”中，该企业使用为了实现这一愿景，我们将通过结果数据推动质量改进，造福人类健康。增强我们现有的计划并增加新的具体目标： 1. 整合我们现有的和新的计划。转化研究导航 (TRN) 计划，鼓励、促进和确保所有人类受试者研究从概念到结论的完整性，这将加快我们的进程参与 CTSA 多中心研究网络 2. 将我们现有的和新的项目整合到一个项目中。转化劳动力教育计划，确保转化劳动力的所有成员拥有单独和作为成员履行职责所需的知识和技能 3. 将我们现有的和新的项目整合到“从发现到健康”中。加强产品计划，以确保调查人员拥有资源来最大限度地提高以下可能性：他们可以将他们的新发现转化为改善人类健康的产品。为了实现这一愿景，我们。将： 1. 整合我们的社区参与导航、协议导航、研究参与者参与协议优先级和设计、基础科学家外展、相互协调的社区参与/机制科学、集中招募和研究志愿者存储库、本体支持的表型分析以及研究参与者感知计划与新的协议实施导航计划 TRN 总体计划将在新的 TRN 管理结构下得到支持，并由高级领导层负责。通过综合信息学基础设施最佳采用实践以及 NIH 和 CTSA 数据标准。支持本地协议和 CTSA 网络协议，TRN 领导层负责联络试用和招聘创新中心 2. 整合我们当前广泛的教育计划，包括 KL2 临床学者计划，其新的教育举措旨在：让社区成员做好准备参与研究团队，加强临床研究护理培训，提供全方位的教育将科学发现转化为增强健康的产品、开发本体论支持的经验表型分析仪器，并查询大型电子健康记录数据库以测试科学假设 3. 整合新的三机构治疗发展研究所，该研究所提供通过 CCTS 试点计划、洛克菲勒项目，接触药物化学家和药物项目管理科学资源中心、纽约基因组中心、新罗伯逊治疗发展基金、 TRN 计划和 CCTS 医院使调查人员能够穿越死亡之谷 1/2 阶段的结果指标将推动整个绩效的改进。项目摘要/摘要第 248 页联系人 PD/PI：Coller, Barry 洛克菲勒大学临床和转化科学中心致力于改善人类通过提供资源和人员支持进行最高质量的研究来改善健康状况人类疾病的预防、诊断和治疗，以及告知和实施公共卫生它还将产生新的方法来改进研究和获得的科学信息。研究进行的方式。