Developmental Projects

发展项目

• 批准号: 8328125
• 负责人: John C Gore
• 金额: $ 9.68万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8328125
• 关键词: Address; Animals; Area; Award; Biostatistics Core; Charge; Complement; Data Analyses; Development; Educational workshop; Ensure; Funding; Goals; Grant; Guidelines; Instruction; Malignant Neoplasms; Methodology; Molecular Probes; Nature; Pilot Projects; Published Comment; Research; Research Personnel; Research Project Grants; Resources; Scientist; Source; Time; United States National Institutes of Health; in vivo Cellular and Molecular Imaging Centers; molecular imaging; outreach program; programs; research facility; web site

The ICMIC will The reviews of our previous section on Developmental Projects were somewhat mixed. In general, our plans to establish a program of Developmental Projects and support new directions for research were considered satisfactory, and overall the projects were found to be "appropriate to the goals of the ICMIC and scientifically promising". However, there were numerous specific scientific criticisms of two of the projects described. In our revised proposal these two projects have been removed. While many of the criticisms were addressable, in the time since the application both of these have found some support from other sources and are further along than may be appropriate. In their place we have included one new project in which the aims accord more closely with the general focus of the ICMIC, and we have retained the project "A quantitative high throughput methodology to aid the discovery of molecular imaging agents" as exemplars of potential development projects. It should be emphasized that these projects are not certain to be supported - they represent two existing proposals for using ICMIC resources that may be worthy of funding, but they are examples only of the type of exploratory research we would support. In practice a competitive solicitation would take place, and the best new ideas would be selected for support. We have not undertaken such a solicitation for this proposal. Nonetheless, we feel the two examples described are worthy of consideration and demonstrate the type and range of grants we would consider supporting with ICMIC resources. Comments were made concerning the lack of statistical considerations for the Developmental Projects, as well as lack of details on animal handling. We have addressed these by (a) adding a Biostatistics Core for data analysis and project planning and (b) by providing much more information on the use of animals in Section G (see also our Introduction to Sections A and B). Our biostatisticians have already been closely involved in preparing the descriptions of the developmental projects. The specific criticisms for the project "A quantitative high throughput methodology to aid the discovery of molecular imaging agents" are addressed immediately before the description of that project. A more general criticism was made when the reviewers commented "The plan for administration of the Development Projects is brief and does not describe the specific efforts of the ICMIC to actively engage in the Development Projects or to promote interactions between the Developmental Project investigators and the Specialized Cores and Research Projects". Some of this information was put into Section B, as per the Instructions. There we state "Review criteria for these pilot project proposals will be similar to that given by NIH for R21 or R03 grants, but with a special emphasis on the collaborative nature of the ICMIC." Thus, we intend to incorporate in the guidelines for submission, and in the criteria for review, a specific emphasis on the integration of the Development Projects with the Specialized Resources. Moreover, each director of the Specialized Resource will be charged with responsibility for ensuring that the Development Projects are supported adequately and make full use of the ICMIC resources. The ICMIC will be very proactive in encouraging new investigators and projects to appreciate the synergies made possible by the organization of the ICMIC. Note that these efforts will complement our very active program outreach, outlined in Section B, or promoting the facilities and research of the ICMIC via websites, seminars, workshops and other means. Given the very compact and intimate character of our campus we anticipate there will be strong connections made between the Development Projects and all other aspects of the ICMIC.

ICMIC将对我们先前关于发展项目的部分的评论有些混杂。通常，我们计划 建立一个开发项目和支持新的研究方向的计划被认为令人满意， 总体而言，这些项目“适合ICMIC和科学有前途的目标”。 但是，对描述的两个项目有许多具体的科学批评。在我们的修订中 提案这两个项目已被删除。尽管许多批评是可以解决的，但 由于应用程序两者都找到了其他来源的支持，并且进一步 比合适的。在他们的位置，我们包括了一个新项目，该项目的目标更多 与ICMIC的一般重点紧密相关，我们保留了“定量高通量”项目 帮助发现分子成像剂的方法作为潜在开发项目的典范。 应该强调的是，这些项目不能得到支持 - 它们代表了两个现有的 使用可能值得资金的ICMIC资源的建议，但它们仅是该类型的示例 我们将支持的探索性研究。在实践中，将会发生竞争性招标，最好 新想法将被选为支持。我们没有为此提案征集。尽管如此， 我们认为所描述的两个示例值得考虑并证明类型和范围 我们将考虑使用ICMIC资源的支持。 关于发展项目缺乏统计考虑的评论 由于缺乏动物处理的细节。我们已经通过（a）为数据添加生物统计学核心来解决这些问题 分析和项目计划以及（b）通过提供有关动物在G节中使用的更多信息 （另请参见我们对A和B节的简介）。我们的生物统计学家已经密切参与准备 发展项目的描述。对该项目的具体批评“定量高 吞吐量方法有助于发现分子成像剂” 该项目的描述。 当审稿人评论“开发计划计划”时，提出了更普遍的批评 项目简短，没有描述ICMIC积极参与发展的具体努力 项目或促进发展项目调查人员与专业的互动 根据说明，核心和研究项目。 我们在那里指出“这些试点项目提案的审查标准将与NIH给出的审查标准相似 R21或R03赠款，但特别强调了ICMIC的协作性质。”因此，我们打算 纳入提交准则和审查标准中，对整合的特定重视 具有专门资源的开发项目。而且，专业的每位主任 资源将负责确保充分支持开发项目 并充分利用ICMIC资源。 ICMIC将非常积极地鼓励新的调查人员 以及欣赏ICMIC组织使协同作用的项目。注意 这些努力将补充我们在B节中概述的非常活跃的计划宣传，或促进设施 以及通过网站，研讨会，研讨会和其他方式对ICMIC进行研究。鉴于非常紧凑 和我们校园的亲密特征，我们期望开发之间会建立牢固的联系 项目和ICMIC的所有其他方面。