Modulators of Cognitive Transition from Normal to MCI

从正常到 MCI 认知转变的调节剂

• 批准号: 8572480
• 负责人: Oscar L. Lopez
• 金额: $ 22.67万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-15 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8572480
• 关键词: Address; Age; Alzheimer' s Disease; Amyloid; Amyloid deposition; Ankle; Attenuated; Blood Tests; Blood Vessels; Blood specimen; Brain; Cardiovascular Diseases; Cerebrovascular Circulation; Cerebrovascular Disorders; Cerebrum; Characteristics; Clinical; Clinical Trials Design; Cognition; Cognitive; Cognitive deficits; Data; Dementia; Deposition; Development; Disease; Effectiveness; Elderly; Electrocardiogram; Evaluation; Event; Face; Financial compensation; Future; Ginkgo biloba; Goals; Hypertension; Image; Impaired cognition; Incidence; Individual; Infarction; Instruction; Knowledge; Lead; Ligands; Link; Longitudinal Studies; MRI Scans; Magnetic Resonance Imaging; Measurable; Measures; Memory; Metabolism; Nerve Degeneration; Neurologic; Neurologic Examination; Normalcy; Outcome; Participant; Pathologic Processes; Pathology; Patients; Pattern; Perfusion; Phase; Pittsburgh Compound-B; Placebos; Plasma; Population; Population Study; Positioning Attribute; Positron-Emission Tomography; Precipitation; Prevalence; Process; Risk Factors; Role; Sampling; Scanning; Series; Severities; Spin Labels; Staging; Structure; Symptoms; Syndrome; Testing; Thick; Vascular Diseases; Visit; amyloid imaging; brain volume; cerebral atrophy; clinical effect; cognitive change; disorder risk; fluorodeoxyglucose positron emission tomography; follow-up; glomerular function; glucose metabolism; improved; in vivo; indexing; intima media; mild neurocognitive impairment; neurobehavioral; neuroimaging; neuropsychological; neurotoxic; normal aging; post gamma-globulins; prospective; response; tau Proteins; vascular factor

PROJECT SUMMARY (See instructions): This proposal is oriented to examine the relationship between the two most important CNS pathologies that occur in the elderly (Alzheimer's disease [AD] and vascular disease) during the pre-symptomatic phase of AD. We will specifically test the hypothesis that the clinical effects of amyloid deposition detected in vivo in the brain of normal individuals who progress to mild cognitive impairment (MCI) and later to AD is modulated by sub-clinical vascular disease. The central hypothesis of this study is that cognitively normal subjects with systemic and cerebral vascular disease will be less likely to mount a compensatory response to amyloid deposition. Elderly subjects with vascular disease, in whom the neuropathological cascade leading to AD has already started, will be less likely to maintain normal cerebral metabolism; they will have a shorter "latency period", and a greater incidence of MCI. By contrast, cognitively normal subjects with less vascular disease will have more amyloid deposition, since they will be able to compensate and maintain a longer 'latency period." This longitudinal study will examine the MRI, PET, and cerebral and systemic vascular characteristics of 70 cognitively normal subjects participating of the Ginkgo Evaluation of Memory Study (GEMS). The GEMS was conducted to determine effectiveness of ginkgo biloba versus placebo in lowering the incidence of all-cause dementia and AD in normal elderly subjects and those with MCI. The GEMS has conducted careful annual cognitive evaluations since 2001 (mean follow-up: 8.5 years) on 966 subjects in Pittsburgh, and the study was completed in 2008. As part of the last examination to be completed in 2010, all non-demented participants in Pittsburgh were invited to have an MRI of the brain and a PET scan with an amyloid ligand (Pittsburgh Compound B), and approximately 200 subjects will be entered in the last phase of GEMS. From this population, we will select 70 cognitively normal participants for the present study; 35 without and 35 with amyloid deposition. Consequently, by sampling from the GEMS, we will be in the unique position of examining the relationship between vascular disease, amyloid deposition and onset of cognitive changes in a normal elderly population.

项目摘要（请参阅说明）： 该提案的定向是检查在AD的症状前症状阶段，在老年人（阿尔茨海默氏病[AD]和血管疾病）中发生的两种最重要的中枢神经系统病理之间的关系。我们将明确检验以下假设：正常个体的大脑中检测到的淀粉样蛋白沉积的临床作用，这些人的大脑发展为轻度认知障碍（MCI），后来又受到亚临床血管疾病的调节。这项研究的中心假设是，具有全身性和脑血管疾病的认知正常受试者对淀粉样蛋白沉积的补偿性反应不太可能。患有血管疾病的老年受试者已经开始了导致AD的神经病理学级联反应，将不太可能维持正常的脑代谢。他们的“延迟期”将较短，MCI的发生率更高。 By contrast, cognitively normal subjects with less vascular disease will have more amyloid deposition, since they will be able to compensate and maintain a longer 'latency period." This longitudinal study will examine the MRI, PET, and cerebral and systemic vascular characteristics of 70 cognitively normal subjects participating of the Ginkgo Evaluation of Memory Study (GEMS). The GEMS was conducted to determine effectiveness of ginkgo biloba与安慰剂在降低正常老年受试者的全因痴呆和AD的发生率和MCI的发生率之间进行了仔细的年度认知评估（平均随访：8.5年），对匹兹堡的966名受试者进行了研究，并在2008年完成了该研究的一部分。带有淀粉样配体（匹兹堡化合物B）的PET扫描，将在宝石的最后阶段输入大约200名受试者。从这个人群中，我们将为本研究选择70名认知正常参与者。 35没有淀粉样蛋白沉积的35。因此，通过从宝石中取样，我们将处于检查正常老年人群中血管疾病，淀粉样蛋白沉积和认知变化发作之间关系的独特位置。