A Genetic Study of Personal Traits that Promote or Inhibit Individual Well-Being

促进或抑制个人福祉的个人特质的遗传学研究

• 批准号: 8298537
• 负责人: Rand Donald Conger
• 金额: $ 103.8万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-23 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8298537
• 关键词: Accounting; Achievement; Address; Adolescent; Affect; Age-Years; Alcohol or Other Drugs use; Archives; Behavior; Behavioral; Biological; Candidate Disease Gene; Case-Control Studies; Cessation of life; Characteristics; Child; Communities; Complex; Crime; DNA; DRD4 gene; Data; Data Analyses; Data Set; Databases; Development; Disinhibition; Emotional; Environment; Environmental Risk Factor; Esthesia; Exons; Failure; Family; Family member; Funding; Generations; Genes; Genetic; Genetic Markers; Genetic Polymorphism; Genetic Risk; Genetic Variation; Genome; Genotype; Goals; Health; Health Benefit; Human Development; Individual; Individual Differences; Informal Social Control; Investigation; Life Cycle Stages; Link; Literature; Longevity; Maps; Measurement; Measures; Methods; Modeling; Molecular Genetics; Motivation; Occupational; Outcome; Parents; Participant; Patient Self-Report; Personal Attribute; Personal Satisfaction; Personality; Phenotype; Population; Prevention; Problem behavior; Procedures; Psychopathology; Public Health; Quantitative Genetics; Records; Reporting; Research; Risk; Risk Behaviors; Sample Size; Sampling; Schools; Self Perception; Shapes; Shiners; Siblings; Social Characteristics; Stimulus; Stratification; Stress; Substance abuse problem; Temperament; Testing; Time; Training; Weight; Work; adverse outcome; aged; anti social; base; cohort; design; emotional distress; family structure; gene environment interaction; genetic pedigree; genetic variant; genome wide association study; improved; indexing; informant; insight; interest; meetings; member; novel; offspring; public health relevance; resilience; skills; social; teacher; time use; trait

DESCRIPTION (provided by applicant): This RO1 application seeks five years of support to conduct a molecular genetics study of an existing community-based sample of over 2,400 participants including 500 cohort members (G2 targets), their close- aged siblings, their parents (G1), their romantic partners, and their oldest biological child (G3). The broad objective of this proposal is to evaluate genetic (G), environmental (E), and gene x environment interaction (GxE) effects on a set of core personality attributes that are linked to a host of important developmental outcomes using a weighted, family-based genome-wide association study (GWAS). Specifically, we propose to examine genetic and environmental contributions to the latent traits of Behavioral Disinhibition (BD) and Dispositional Resilience (DR). BD reflects excessive pursuit of exciting appetitive stimuli, disregard for the aversive consequences of risky behaviors, and a tendency to engage in aggressive acts that demonstrate a lack of concern for others. Conversely, DR reflects emotional stability, interpersonal sensitivity, and a self-confident and self-directed orientation to meeting achievement-related challenges. These attributes are present as early as toddlerhood and continue to have important developmental consequences across the life course. In particular these attributes influence whether individuals develop specific competencies and strong interpersonal relationships or whether individuals develop problems that can significantly impair their health and well-being such as involvement with substances, crime, and engaging in risky behaviors. To address these important questions, we will use both existing data from the Family Transitions Project (FTP) as well as genetic information to be collected as part of the proposed study. The FTP was initiated in 1989 when the G2 targets were early adolescents and has continued with annual assessments since that time. The G2 cohort members now average 33 years of age. Each generation in the study has been assessed over a several year period of time using a measurement strategy that is both extensive (i.e., covers multiple domains of personal and social characteristics) and intensive (i.e., employs a multi- informant approach that includes self-reports, other family member reports, teacher reports, ratings by trained observers, school records and public records). Requested funds will be used to collect DNA and genotype the FTP participants. Genotypic information will be combined with the existing archive of contextual and phenotypic data to evaluate genetic and environmental influences on BD and DR. In particular, the unique family structures in this sample include genetically-informative parent-offspring (both G1-G2 and G2-G3) and sibling relationships (G2) which will be ideal for Family-Based Association Test (FBAT) methods. PUBLIC HEALTH RELEVANCE: The goal of the current study is to increase understanding of genetic and environmental factors that shape specific personal attributes that are linked with both maladaptive and adaptive developmental outcomes across the life span. Attributes such as achievement motivation, interpersonal sensitivity, and a positive identity tend to promote successful adaptation, whereas attributes linked with behavioral disinhibition are associated with substance use, crime, health risks, and interpersonal difficulties. The clarification of the genetic and environmental underpinnings of these traits has the potential for enormous public health benefits. Indeed, results from the proposed study should provide specific insights that can inform prevention and treatment efforts designed to promote healthy human development and to reduce psychopathology and problem behaviors.

描述（由申请人提供）：此RO1应用程序寻求五年的支持，以进行分子遗传学研究，对现有社区的2400多名参与者的样本，包括500名队列成员（G2目标）（G2目标），他们的近亲兄弟姐妹，父母（G1），他们的浪漫伴侣，他们的浪漫伴侣，他们的年龄最大的生物学孩子（G3）。该提案的广泛目的是评估遗传（G），环境（E）和基因X环境相互作用（GXE）对一组核心人格属性的影响，这些核心人格属性与一系列重要的，基于家庭基因组的基因组范围的协会研究（GWAS）相关。具体而言，我们建议检查对行为抑制（BD）和性格弹性（DR）的潜在特征的遗传和环境贡献。 BD反映了对激动人心的食欲刺激的过度追求，无视冒险行为的厌恶后果，以及倾向于从事积极行为，表现出对他人缺乏关注的趋势。相反，DR反映了情绪稳定，人际关系敏感性，以及以应对成就相关的挑战的自信心和自我指导的方向。这些属性早在蹒跚学步时就存在，并继续在整个生活过程中产生重要的发展后果。特别是这些属性会影响个人是否发展特定的能力和牢固的人际关系，或者个人是否发展出可能会严重损害其健康和福祉的问题，例如参与物质，犯罪和从事风险行为。 为了解决这些重要问题，我们将使用家庭过渡项目（FTP）中的现有数据以及作为拟议研究的一部分收集的遗传信息。 FTP始于1989年，当时G2目标是早期的青少年，自那时以来一直在进行年度评估。 G2队列成员现在平均33岁。研究中的每一代人都使用广泛的测量策略（即涵盖了个人和社会特征的多个领域）和密集（即采用多个线条方法，包括自我报告，其他家庭成员报告，其他家庭成员报告，教师报告，受过训练的观察者，学校记录和公共记录）。要求的资金将用于收集FTP参与者的DNA和基因型。基因型信息将与现有的上下文和表型数据的档案结合使用，以评估对BD和DR的遗传和环境影响。特别是，该样本中的独特家庭结构包括遗传信息的父源（G1-G2和G2-G3）和兄弟姐妹关系（G2），这将是基于家庭的关联测试（FBAT）方法的理想选择。 公共卫生相关性：当前研究的目的是提高对构成特定个人属性的遗传和环境因素的理解，这些因素与适应性和适应性发展的特定属性有关。诸如成就动机，人际关系敏感性和积极认同等属性倾向于促进成功适应，而与行为抑制相关的属性与药物使用，犯罪，健康风险和人际关系困难有关。阐明这些特征的遗传和环境基础有可能获得巨大的公共卫生益处。实际上，拟议研究的结果应提供特定的见解，可以为旨在促进健康人类发展并减少精神病理学和问题行为的预防和治疗工作提供依据。