Identify the strategies that tissues use to control growth

确定组织用于控制生长的策略

• 批准号: 8516154
• 负责人: ANNE LEIGHTON CALOF
• 金额: $ 38.66万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8516154
• 关键词: Activins; Alveolus; Architecture; Back; Behavior; Caenorhabditis elegans; Cell Count; Cell Cycle; Cell Lineage; Cells; Commit; Development; Duct (organ) structure; Epithelium; Equilibrium; Face; Family; Feedback; Gonadal structure; Grant; Growth; Homeostasis; Injury; Intestines; Lobule; Modeling; Morphogenesis; Mus; Natural regeneration; Olfactory Epithelium; Organ; Output; Phenotype; Play; Polyps; Probability; Proliferating; Role; Staging; Stem cells; Structure; System; Systems Biology; TGFB1 gene; Thick; Tissues; Villus; adenoma; cell type; feeding; intestinal crypt; intestinal epithelium; mutant; progenitor; self-renewal; stem cell niche

THEME B: CONTROL OF GROWTH AND MORPHOGENESIS (Anne Calof, Theme Leader) I Epithelia are organized sheets of cells that play a central role in determining the sizes and 3D architectures of our organs. Ducts, lobules, buds, alveoli, even stem cell niches, all take their form through the actions of epithelia during development. During the past grant period, through studies of the mouse olfactory epithelium OE), we made great progress in understanding how negative feedback control of self-renewal is used to achieve robust size homeostasis and rapid regeneration [19-24]. This strategy solves some of the problems that epithelia face, but not others, such as control of planar expansion; creation of morphogenetic units; and protection of cell lineages from accumulated damage. Here we take up these questions, returning to the OE, but also introducing two new systems: the mouse intestinal epithelium (IE) and the C. elegans gonad.

主题B：对成长和形态发生的控制（Anne Calof，主题负责人） 上皮是有组织的细胞床单，在确定器官的尺寸和3D架构中起着核心作用。管道，小叶，芽，肺泡，甚至干细胞壁ni，都通过发育过程中上皮的作用而形成。在过去的赠款期间，通过对小鼠嗅觉上皮OE的研究，我们在理解自我更新的负面反馈控制如何实现稳健尺寸的稳态和快速再生方面取得了重大进展[19-24]。该策略解决了上皮亚面临的一些问题，而不是其他问题，例如控制平面扩张；形态发生单位的创建；并保护细胞谱系免受累积损害。在这里，我们提出了这些问题，返回OE，但也引入了两个新系统：鼠标肠上皮（IE）和C. elegans gonad。