Imaging Viral Immunity

病毒免疫成像

• 批准号: 8555967
• 负责人: JACK R BENNINK
• 金额: $ 59.6万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8555967
• 关键词: Cells; Event; Goals; HIV; Image; Imagery; Immune; Immune response; Immune system; Immunity; Immunologic Memory; Infection; Life; Microscope; Mus; Muscle; Organ; Public Health; Skin; T-Lymphocyte; Tissues; Vaccination; Vaccines; Viral; Virus; Virus Diseases; design; improved; in vivo; killings; lymph nodes

Vaccines have led to many of the world's greatest public health triumphs, but many deadly viruses, such as HIV, elude the best efforts to develop effective vaccines. An improved understanding of how the immune system operates during a viral infection is critical to designing successful anti-virus vaccines, particularly those designed to elicit T cells, which have the ability to kill virus infected cells before progeny viruses are produced. Many vaccines are delivered in the skin or muscle, where they initiate immune responses in draining lymph nodes. To better understand how live virus vaccines activate T cells, we are using a multiphoton microscope to visualize the interaction of T cells with viruses in living mice.

疫苗导致了世界上许多最大的公共卫生胜利，但许多致命病毒（例如艾滋病毒）避免了开发有效疫苗的最佳努力。人们对在病毒感染期间免疫系统运作的方式有了深入的了解，对于设计成功的抗病毒疫苗，尤其是那些旨在引起T细胞的疫苗，这些疫苗具有在产生后代病毒之前杀死病毒感染细胞的能力。 许多疫苗在皮肤或肌肉中输送，在这些疫苗中，它们在排水淋巴结中引发免疫反应。为了更好地了解活病毒疫苗如何激活T细胞，我们使用多光子显微镜可视化活小鼠中T细胞与病毒的相互作用。