Physiology of Viral Immunity

病毒免疫生理学

• 批准号: 8336267
• 负责人: JACK R BENNINK
• 金额: $ 54.87万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8336267
• 关键词: Ablation; Affect; Antiviral Response; CD8B1 gene; Cellular Immunity; Chemicals; Communication; Complex; Environment; Goals; Immune; Immune response; Immune system; Immunity; Immunology; Influenza; Mus; Nature; Organ; Parasympathetic Nervous System; Pathogenesis; Research; Role; T cell response; Tissues; Viral; Viral Antigens; Viral Physiology; Virus Diseases

The vertebrate immune systems operate in the complex environment of vertebrate tissues and organs. Much of current immunology research examines immune mechanisms isolated from their natural milieu. In this project our approach is to place the anti-viral immune response in its global context. We have begun these studies by examining the role of the sympathetic and parasympathetic nervous system on anti-viral responses. Despite the longstanding appreciation of communication between the nervous and the immune systems, the nature and significance of these interactions to immunity remains enigmatic. Our studies will examine chemical ablation of the mouse sympathetic and parasympathetic nervous systems and its affect on primary and secondary CD8+ T cell responses to viral antigens.

脊椎动物免疫系统在脊椎动物组织和器官的复杂环境中运行。 当前的许多免疫学研究检查了从其天然环境中分离出来的免疫机制。 在这个项目中，我们的方法是将抗病毒免疫反应置于其全球背景下。 我们已经通过研究交感神经和副交感神经系统对抗病毒反应的作用开始了这些研究。尽管神经和免疫系统之间的沟通很长，但这些与免疫相互作用的性质和意义仍然是神秘的。 我们的研究将检查小鼠交感神经和副交感神经系统的化学消融及其对初级和继发性CD8+ T细胞对病毒抗原的反应的影响。

项目成果

Cutting edge: Sympathetic nervous system increases proinflammatory cytokines and exacerbates influenza A virus pathogenesis.

最前沿：交感神经系统会增加促炎细胞因子并加剧甲型流感病毒的发病机制。

• DOI: 10.4049/jimmunol.0903395
• 发表时间: 2010-01-15
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Grebe, Kristie M.;Takeda, Kazuyo;Hickman, Heather D.;Bailey, Adam M.;Embryo, Alan C.;Bennink, Jack R.;Yewdell, Jonathan W.
• 通讯作者: Yewdell, Jonathan W.