Epidemiology and Biomarkers of Parkinsonism in Welders

焊工帕金森病的流行病学和生物标志物

• 批准号: 8265645
• 负责人: Brad A Racette
• 金额: $ 13.19万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8265645
• 关键词: Affect; Age; Age of Onset; Biological Markers; Blood; Carbon Dioxide; Case-Control Studies; Categories; Cessation of life; Clinic; Clinical; Cognitive; Cohort Studies; Collaborations; Communities; Conflict (Psychology); Contralateral; Control Groups; Corpus striatum structure; Data; Death Certificates; Diagnosis; Diagnostic; Discipline; Disease; Doctor of Medicine; Doctor of Philosophy; Dose; Electrodes; Elements; Environment; Environmental Exposure; Environmental Risk Factor; Epidemiologic Studies; Epidemiologist; Epidemiology; Etiology; Exposure to; Family; Filler; Fingers; Foundations; Foxes; Frequencies; Funding; Gases; Gene Mutation; General Population; Globus Pallidus; Heating; High Prevalence; Industrial Health; Industry; Institution; International; Joints; Lead; Lead Poisoning; Magnetic Resonance Imaging; Manganese; Manuals; Measures; Mentors; Metal exposure; Metals; Modification; Morbidity - disease rate; Motor; Movement Disorders; Myoclonus; National Institute of Environmental Health Sciences; Neurodegenerative Disorders; Neurologic; Neurologic Examination; Neurology; Noble Gases; North America; Occupational; Occupational Exposure; Occupational Medicine; Occupations; Onset of illness; Parents; Parkinson Disease; Parkinsonian Disorders; Particulate; Patients; Peripheral Nerves; Phenotype; Positron-Emission Tomography; Prevalence; Principal Investigator; Process; Public Health; Questionnaires; Recording of previous events; Recruitment Activity; Relative Risks; Reporting; Research; Research Personnel; Research Proposals; Research Support; Resources; Risk Factors; SECTM1 gene; Safety; Sampling; Screening procedure; Series; Severities; Siblings; Signal Transduction; Signs and Symptoms; Sleep disturbances; Specialist; Study Subject; Study of magnetics; Surveys; Syndrome; Technology; Testing; Time; Trade Unions; Tungsten; Twin Multiple Birth; United States; Veterans; Weight; Welding; Work; Workplace; base; career; clinical Diagnosis; cohort; comparison group; disorder control; epidemiology study; hazard; lectures; magnetic field; melting; member; nervous system disorder; neuroimaging; neurotoxicity; patient oriented; population based; programs; putamen; ranpirnase; response; retiree; sex; treatment strategy; uptake; web-enabled

DESCRIPTION (provided by applicant): PROJECT SUMMARY: Parkinson's disease (PD) is a neurodegenerative disorder affecting one million people in North America. There is no known cause for most cases of PD although environmental factors have been implicated in the majority of cases. We have preliminary evidence that parkinsonism is three to ten times more common in career welders than the general population. We have an NIEHS and Michael J. Fox Foundation funded research program to investigate welding as a risk-factor for parkinsonism. For the funded research, we will perform a population based, epidemiology study of the prevalence of parkinsonism in career welders and controls. We will assemble a cohort of 875 active shipyard workers (and retirees) and 200 same-sex, nearest age, sibling controls. Movement disorders specialists will examine all subjects for parkinsonism. Prevalence of parkinsonism will be compared between shipyard welders, non-welder shipyard workers and the non-welder, same-sex, sibling controls. An industrial hygienist will reconstruct subject welding exposure from a detailed exposure questionnaire in all exposed subjects and subjects will be grouped into tertiles of exposure using a Job Exposure Matrix (JEM) to determine if there is a dose-response relationship between welding exposure and parkinsonism. New research to be supported by this proposal includes assessment of the relationship between blood manganese levels and increased Tl-weighted signal changes in globus pallidum. In addition, we will determine if lifetime welding exposure reconstructed from a validated questionnaire and categorized by a JEM is associated with a dose dependent decrease in [18FJFDOPA striatal uptake using PET and with greater severity of parkinsonism as measured by clinical examination and timed motor tasks. The team conducting this research represents a unique collaboration of movement disorders specialists, epidemiologists, occupational medicine specialists, industrial hygienists, and industry leaders. Demonstrating a definitive relationship between welding and parkinsonism will have substantial public health impact since the majority of these cases should be preventable through worksite modifications. This multi-institution and multi-discipline research program, in addition to the numerous educational (institutional K12, extensive lectures/seminar series) and collaborative resources in the Department of Neurology (P30), makes this research proposal an ideal environment to mentor trainees in patient-oriented neurological research. RELEVANCE: None provided.

描述（由申请人提供）： 项目摘要：帕金森病 (PD) 是一种影响北美一百万人的神经退行性疾病。尽管环境因素与大多数帕金森病病例有关，但大多数帕金森病病例的病因尚不清楚。我们有初步证据表明，职业焊工中帕金森病的发病率是普通人群的三到十倍。我们有一个 NIEHS 和 Michael J. Fox 基金会资助的研究项目，旨在调查焊接作为帕金森病的危险因素。对于资助的研究，我们将对职业焊工和控制人员中帕金森病的患病率进行一项基于人群的流行病学研究。我们将召集 875 名在职造船厂工人（和退休人员）和 200 名同性、年龄最接近的兄弟姐妹作为对照组。运动障碍专家将对所有受试者进行帕金森症检查。将比较造船厂焊工、非焊工造船厂工人和非焊工、同性、兄弟姐妹之间的帕金森病患病率。工业卫生员将根据所有暴露受试者的详细暴露调查问卷重建受试者焊接暴露，并使用工作暴露矩阵 (JEM) 将受试者分为暴露三分位数，以确定焊接暴露与帕金森病之间是否存在剂量反应关系。该提案支持的新研究包括评估血锰水平与苍白球中 Tl 加权信号变化增加之间的关系。此外，我们将确定根据经过验证的调查问卷重建并通过 JEM 分类的终生焊接暴露是否与使用 PET 的 [18FJFDOPA 纹状体摄取的剂量依赖性减少有关，以及通过临床检查和定时运动任务测量的帕金森病的严重程度是否与帕金森病的严重程度有关。进行这项研究的团队代表了运动障碍专家、流行病学家、职业医学专家、工业卫生学家和行业领导者的独特合作。证明焊接与帕金森症之间的明确关系将对公众健康产生重大影响，因为大多数此类病例应该可以通过改造工作场所来预防。这个多机构和多学科的研究项目，加上神经病学系 (P30) 的众多教育（机构 K12、广泛的讲座/研讨会系列）和协作资源，使该研究计划成为指导学员的理想环境。以患者为导向的神经学研究。相关性：未提供。