Motor and Cognitive Health Outcomes in a Mn-Exposed African Community
接触锰的非洲社区的运动和认知健康结果
基本信息
- 批准号:9115153
- 负责人:
- 金额:$ 52.82万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-08-01 至 2020-04-30
- 项目状态:已结题
- 来源:
- 关键词:AdultAdverse effectsAfricanAgeBehavior assessmentBehavioralBlack raceClinical assessmentsCognitiveCommunitiesComplexDataDoseEnvironmental ExposureEnvironmental PollutionEpidemiologyExposure toFunctional disorderGoalsHealthHigh PrevalenceLifeLinkManganeseModelingMoodsMotorNeurotoxinsOutcomeParkinson DiseaseParkinsonian DisordersParticipantPathway interactionsPharmacologyPhenotypePlantsPoliciesPopulationPrevalencePublic HealthRaceResearchRiskRoleSeveritiesSouth AfricaSouth AfricanTestingTrace ElementsUnited StatesUnited States Environmental Protection AgencyWorkcognitive controldisturbance in affectepidemiology studymotor disorderneuropsychologicalneurotoxicitypopulation basedpresynapticracial differenceresponse
项目摘要
DESCRIPTION (provided by applicant): Manganese (Mn) is an established neurotoxicant with complex pharmacology, due to its role as an essential trace element. This proposal builds on a large body of research generated by our investigative team over the last decade. In these studies, we have demonstrated that: Mn-exposed welders have a high prevalence of parkinsonism compared to a reference population; the phenotype of parkinsonism in Mn-exposed workers overlaps substantially with the phenotype seen in Parkinson disease (PD); Mn-exposed workers have presynaptic dopaminergic dysfunction, thereby linking Mn exposure to the same pathways involved in PD; and there is an increased risk of PD in regions of the U.S. with high industrial Mn emissions. In this proposal, we will perform a population-based epidemiology study of Mn-exposed adults living near a large Mn smelter in Meyerton, South Africa, and of a non-exposed reference community in Kroonstad, South Africa, in which we will compare the prevalence and severity of motor, cognitive control, and mood dysfunction between the two communities. Within the Mn-exposed Meyerton community, we will also investigate the dose-response relationship between environmental Mn exposure and these health outcomes. Our preliminary data clearly support the hypotheses we propose to test and demonstrate that the proposed work is feasible. Our research team is ideally suited to conduct these studies and includes world experts in clinical assessment of Mn neurotoxicity, environmental pollution modeling, and epidemiology. The mixed-race (black and white) South African community to be studied will provide a unique opportunity to investigate racial differences to sensitivity to Mn. Demonstrating motor and cognitive health effects from ambient Mn at exposure levels below the current Environmental Protection Agency lowest observed adverse effect level will have a substantial public health impact by informing environmental regulatory policy in the United States and worldwide.
描述(由适用提供):锰(MN)是一种具有复杂药理学的神经毒性,因为它是必不可少的痕量元素。该提案建立在过去十年来调查团队产生的大量研究的基础上。在这些研究中,我们已经证明:与参考人群相比,帕金森氏症患病率很高;帕金森氏症工人中帕金森氏症的表型与帕金森氏病(PD)中的表型显着重叠。暴露于MN的工人患有突触前多巴胺能功能障碍,从而将MN暴露与PD相同的途径联系起来;而且,在美国地区高级MN排放量高的美国地区,PD的风险增加了。在这项建议中,我们将对居住在南非梅耶顿的大型MN冶炼厂附近的MN暴露成年人以及南非克鲁恩斯塔德的非暴露参考社区进行基于人群的流行病学研究,我们将在其中比较两个社区之间运动,认知控制和情绪功能障碍的流行和严重性。在公平的Meyerton社区中,我们还将调查环境MN暴露与这些健康结果之间的剂量反应关系。我们的初步数据显然支持我们提出的测试假设,并证明拟议的工作是可行的。我们的研究团队非常适合进行这些研究,并包括有关MN神经毒性,环境污染建模和流行病学的临床评估的世界专家。曾研究的混合种族(黑白)南非社区将提供一个独特的机会,以调查对MN敏感性的种族差异。通过向当前环境保护局低于当前环境保护局的暴露水平的运动和认知健康效应,最低观察到的不利影响水平将通过告知美国和全球环境监管政策,从而产生重大的公共卫生影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Brad A Racette其他文献
Brad A Racette的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Brad A Racette', 18)}}的其他基金
Imaging Biomarkers of Neurotoxicity in Welders
焊工神经毒性的成像生物标志物
- 批准号:
10747199 - 财政年份:2023
- 资助金额:
$ 52.82万 - 项目类别:
Imaging Biomarkers of Neurotoxicity in Welders
焊工神经毒性的成像生物标志物
- 批准号:
10659057 - 财政年份:2023
- 资助金额:
$ 52.82万 - 项目类别:
Manganese-Induced Neurotoxic Effects Research in South Africa
南非锰诱发的神经毒性作用研究
- 批准号:
10805968 - 财政年份:2023
- 资助金额:
$ 52.82万 - 项目类别:
Manganese-Induced Neurotoxic Effects Research in South Africa (MINERS)
南非锰诱发的神经毒性效应研究 (MINERS)
- 批准号:
10242754 - 财政年份:2017
- 资助金额:
$ 52.82万 - 项目类别:
Manganese-Induced Neurotoxic Effects Research in South Africa (MINERS)
南非锰诱发的神经毒性效应研究 (MINERS)
- 批准号:
9768467 - 财政年份:2017
- 资助金额:
$ 52.82万 - 项目类别:
Motor and Cognitive Health Outcomes in a Mn-Exposed African Community
接触锰的非洲社区的运动和认知健康结果
- 批准号:
8975835 - 财政年份:2015
- 资助金额:
$ 52.82万 - 项目类别:
Motor and Cognitive Health Outcomes in a Mn-Exposed African Community
接触锰的非洲社区的运动和认知健康结果
- 批准号:
9236970 - 财政年份:2015
- 资助金额:
$ 52.82万 - 项目类别:
Risk of Parkinson Disease Associated with Solvent Exposures in Finland
芬兰与溶剂接触相关的帕金森病风险
- 批准号:
8752056 - 财政年份:2014
- 资助金额:
$ 52.82万 - 项目类别:
Risk of Parkinson Disease Associated with Solvent Exposures in Finland
芬兰与溶剂接触相关的帕金森病风险
- 批准号:
8916722 - 财政年份:2014
- 资助金额:
$ 52.82万 - 项目类别:
Imaging Biomarkers of Neurotoxicity in Welders
焊工神经毒性的成像生物标志物
- 批准号:
8593295 - 财政年份:2012
- 资助金额:
$ 52.82万 - 项目类别:
相似国自然基金
基因与家庭不利环境影响儿童反社会行为的表观遗传机制:一项追踪研究
- 批准号:
- 批准年份:2020
- 资助金额:58 万元
- 项目类别:面上项目
不利地质结构对地下洞室群围岩地震响应影响研究
- 批准号:51009131
- 批准年份:2010
- 资助金额:20.0 万元
- 项目类别:青年科学基金项目
列车制动力对铁路桥梁的作用机理及最不利影响的研究
- 批准号:50178004
- 批准年份:2001
- 资助金额:23.0 万元
- 项目类别:面上项目
相似海外基金
Integrated, Individualized, and Intelligent Prescribing (I3P) Clinical Trial Network
一体化、个体化、智能处方(I3P)临床试验网络
- 批准号:
10822651 - 财政年份:2023
- 资助金额:
$ 52.82万 - 项目类别:
The impact of structural racism and discrimination on chronic pain in Black or African American older adults: Biopsychosocial mechanisms
结构性种族主义和歧视对黑人或非裔美国老年人慢性疼痛的影响:生物心理社会机制
- 批准号:
10635199 - 财政年份:2023
- 资助金额:
$ 52.82万 - 项目类别:
New pathways to prevention from community TB screening in South Africa
南非社区结核病筛查预防的新途径
- 批准号:
10760095 - 财政年份:2023
- 资助金额:
$ 52.82万 - 项目类别:
The role of momentary acute discrimination and cultural resilience in polysubstance use among adults from communities of color
短暂的严重歧视和文化复原力在有色人种社区成年人使用多种物质中的作用
- 批准号:
10585788 - 财政年份:2023
- 资助金额:
$ 52.82万 - 项目类别: