Risk of Parkinson Disease Associated with Solvent Exposures in Finland

芬兰与溶剂接触相关的帕金森病风险

• 批准号: 8916722
• 负责人: Brad A Racette
• 金额: $ 15.87万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-25 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8916722
• 关键词: Age; Age of Onset; Aromatic Hydrocarbons; Benzene; Case-Control Studies; Censuses; Chlorinated Hydrocarbons; Collaborations; Comorbidity; Comprehensive Health Care; Coronary heart disease; Country; Data; Databases; Dementia; Disease; Disease Progression; Elderly; Emergency Situation; Environmental Air Pollutants; Epidemiologic Studies; Evaluation; Exposure to; Finland; Health; Healthcare; Hip Fractures; Hydrocarbons; Immigration; Individual; Institutes; Institution; Link; Malignant Neoplasms; Mechanics; Mental Depression; Metals; Methylene Chloride; Morbidity - disease rate; Neurodegenerative Disorders; Neurologist; Occupational; Occupational Epidemiology; Occupational Exposure; Occupational Health; Occupations; Onset of illness; Organic solvent product; Parkinson Disease; Parkinsonian Disorders; Pensions; Persons; Pharmacotherapy; Phenotype; Plastics; Population; Prevention; Psychotic Disorders; Public Health; Public Policy; Records; Registries; Relative Risks; Research Personnel; Risk; Risk Factors; Solvents; Symptoms; Tetrachloroethylene; Toluene; Trichloroethanes; Trichloroethylene; Universities; Washington; Water Pollutants; Work; cohort; comparison group; compliance behavior; disease diagnosis; disorder risk; falls; migration; mortality; neuropsychiatry; neurotoxic; population based; population health; sex; treatment planning; urban area

DESCRIPTION (provided by applicant): Parkinson disease (PD) is a common disease of the elderly associated with substantial morbidity and early mortality. The causes of PD are largely unknown, but recent studies in small cohorts have implicated occupational exposure to neurotoxic solvents. Demonstrating a relation in a larger study would provide an opportunity to reduce exposures and hence disease risk. This is particularly important given the lack of any definitive pharmacotherapy to slow disease progression. Moreover, prevention would not be limited to workers with high exposures such as painters, mechanics, metal workers and plastic workers, since solvents are common environmental air and water pollutants in urban areas of the US. This proposal investigates the relation between occupational solvent exposure and incident PD in a large and efficiently-constructed, population-based study using existing data in Finland. Finland is an ideal country in which to conduct the studies described below due to low migration/immigration, universal health care, PD diagnoses made by neurologists, and high patient compliance with treatment plans. For this study, we will link the Finnish national population registry to the national comprehensive health care database to identify incident PD cases and a highly suitable comparison group, along with a wealth of covariate data for all subjects. We will further link these data with individual-level occupational data from the Finnish census and national pension database, and then estimate occupational solvent exposure, using the validated Finnish Job-Exposure Matrix (FINJEM). These Finnish databases have been used extensively to investigate occupational risk factors for many other diseases, including cancer and coronary heart disease, but remain to be used to investigate occupational risks associated with PD or other neurodegenerative diseases. The investigators and institutions in this proposal are ideally suited to perform the proposed study, representing the leading occupational health experts from the Finnish Institute of Occupational Health (FIOH) and well-established occupational epidemiology research collaboration between Washington University and the University of Washington.

描述（由申请人提供）：帕金森氏病（PD）是与大量发病率和早期死亡相关的老年人的常见疾病。 PD的原因在很大程度上是未知的，但是在小队列中的最新研究暗示了职业暴露于神经毒性溶剂。在更大的研究中证明关系将为减少暴露和疾病风险提供机会。鉴于缺乏任何确定的药物治疗来缓慢疾病进展，这一点尤其重要。此外，由于溶剂是美国市区的常见环境空气和水污染物，因此预防不仅限于诸如画家，力学，金属工人和塑料工人之类的高暴露工人。该提案使用芬兰现有数据研究了一项大型且有效构建的基于人群的研究中的职业溶剂暴露与事件PD之间的关系。芬兰是一个理想的国家，在其中进行下面描述的研究是由于迁移/移民较低，全民医疗保健，神经科医生做出的PD诊断以及患者对治疗计划的高度依从性的理想国家。在这项研究中，我们将将芬兰国家人口登记处与国家综合医疗保健数据库联系起来，以确定事件PD案件和高度合适的比较组，以及所有受试者的大量协变量数据。我们将使用经过验证的Finnish Job-Sparosure Matrix（FINJEM）将这些数据进一步将这些数据与芬兰人口普查和国家养老金数据库的个人职业数据联系起来。这些芬兰数据库已被广泛用于研究许多其他疾病（包括癌症和冠心病）的职业风险因素，但仍有待调查与PD或其他神经退行性疾病有关的职业风险。该提案中的研究人员和机构非常适合进行拟议的研究，代表芬兰职业健康研究所（FIOH）的领先职业健康专家以及华盛顿大学与华盛顿大学之间的职业流行病学研究合作。