Validation of a Robotic Surrogate for Measurement of Early Childhood Personal Exp

用于测量幼儿个人经历的机器人替代者的验证

• 批准号: 8327197
• 负责人: Stuart Lloyd Shalat
• 金额: $ 15.61万
• 依托单位: UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8327197
• 关键词: 2 year old; 3 year old; Address; Age; Age-Months; Air; Airborne Particulate Matter; Area; Asthma; Behavior; Breathing; Child; Childhood; Childhood Asthma; Collection; Development; Devices; Disease; Dose; Environmental Pollution; Epidemiology; Equipment; Etiology; Exposure to; Family; Floor; Funding; Goals; Home environment; House Dust; Household; Infant; Link; Measurement; Measures; Methodology; Methods; Movement; National Institute of Environmental Health Sciences; New Jersey; Participant; Particulate Matter; Pattern; Play; Population Study; Recruitment Activity; Research Personnel; Robot; Robotics; Sampling; Science; Side; Study Subject; System; Technology; Testing; Toddler; Toxic Environmental Substances; Validation; Weight; air sampling; boys; cohort; design; early childhood; environmental chemical; environmental particulate; girls; novel; programs; tool; toxicant; validation studies

DESCRIPTION (provided by applicant): The study proposes to validate a robotic surrogate - the Pre-toddler Inhalable Particulate Environmental Robotic (PIPER) sampler - for collecting personal exposures of particulate matter (PM) in a study population which is too young to have personal exposure collected accurately by existing methodologies. Exposure and dose estimation are essential to understanding the etiology of environmentally linked childhood diseases. The behavior of resuspended PM suggests that stationary general area measurements taken in homes may underestimate these exposures in young children. Additionally, peak levels of PM exposure may be important in understanding the origins of early childhood conditions such as asthma. Unfortunately the size and weight of sampling equipment limit or preclude their use for PM direct measurements of exposures in very young children, such as infants and toddlers (ages >6 to 36 months). The Pre-toddler Inhalable Particulate Environmental Robotic (PIPER Mk IV) has been developed over the last 5 years to provide a surrogate method to ascertain personal exposures to PM for children too young to have exposure measured by conventional personal sampling methodologies. PIPER provides a mobile autonomous platform on which to mount personal sampling devices. PIPER has been programmed to reproduce the pattern of a child's movement while at play on the floor, and as would a child disturbs and resuspends settled housedust. The PIPER Mk IV is the result of over 5 years of development and testing and has proven its reliability in tests in over 50 homes participating in an NIEHS funded (R01-ES014717) study. A validation study of an alternate personal sampling methodology using a robotic surrogate (PIPER) for young children's exposure to PM is proposed. The study will be carried out by mounting identical sampling systems on PIPER in side-by- side comparison with 100 children (50 boys and 50 girls) at play in their own homes. Children between >24 and 36 months of age will be recruited from participants of the existing PIPER Asthma Study and the pediatric practices participating in that study in central New Jersey. The goal of this validation study is to provide researchers with a new and novel tool for characterizing young children's exposure to environmental contaminants.

描述（由申请人提供）：该研究提议验证机器人替代品 - 学步前儿童可吸入颗粒环境机器人 (PIPER) 采样器 - 用于收集研究人群中颗粒物 (PM) 的个人暴露情况，该人群年龄太小，无法拥有个人数据。通过现有方法准确收集暴露量。暴露和剂量估计对于了解与环境有关的儿童疾病的病因至关重要。悬浮颗粒物的行为表明，在家中进行的固定一般面积测量可能会低估幼儿的这些暴露。此外，PM 暴露的峰值水平对于了解哮喘等幼儿疾病的起源可能很重要。遗憾的是，采样设备的尺寸和重量限制或妨碍了其用于幼儿（例如婴儿和幼儿（年龄 > 6 至 36 个月））暴露的 PM 直接测量。学步前儿童可吸入颗粒环境机器人 (PIPER Mk IV) 是在过去 5 年中开发出来的，旨在为年龄太小而无法通过传统个人采样方法测量暴露量的儿童提供一种替代方法来确定其个人接触 PM 的情况。 PIPER 提供了一个移动自主平台，可在其上安装个人采样设备。 PIPER 已被编程为重现儿童在地板上玩耍时的运动模式，就像儿童扰动并重新悬浮已沉积的室内灰尘一样。 PIPER Mk IV 是经过 5 年多的开发和测试的结果，并在参与 NIEHS 资助的 (R01-ES014717) 研究的 50 多个家庭的测试中证明了其可靠性。建议使用机器人替代者 (PIPER) 来验证幼儿接触 PM 的替代个人采样方法。该研究将通过在 PIPER 上安装相同的采样系统，与 100 名在自己家中玩耍的儿童（50 名男孩和 50 名女孩）进行并排比较。年龄大于 24 至 36 个月的儿童将从现有 PIPER 哮喘研究的参与者以及新泽西州中部参与该研究的儿科诊所中招募。这项验证研究的目的是为研究人员提供一种新颖的工具来描述幼儿接触环境污染物的情况。