Validation of a Robotic Surrogate for Measurement of Early Childhood Personal Exp

用于测量幼儿个人经历的机器人替代者的验证

• 批准号: 8736327
• 负责人: Stuart Lloyd Shalat
• 金额: $ 28.47万
• 依托单位: RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2015-12-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8736327
• 关键词: Validation; Robotic; Surrogate; Measurement; Early; Validation; Robotic; Surrogate; Measurement; Early

DESCRIPTION (provided by applicant): The study proposes to validate a robotic surrogate - the Pre-toddler Inhalable Particulate Environmental Robotic (PIPER) sampler - for collecting personal exposures of particulate matter (PM) in a study population which is too young to have personal exposure collected accurately by existing methodologies. Exposure and dose estimation are essential to understanding the etiology of environmentally linked childhood diseases. The behavior of resuspended PM suggests that stationary general area measurements taken in homes may underestimate these exposures in young children. Additionally, peak levels of PM exposure may be important in understanding the origins of early childhood conditions such as asthma. Unfortunately the size and weight of sampling equipment limit or preclude their use for PM direct measurements of exposures in very young children, such as infants and toddlers (ages >6 to 36 months). The Pre-toddler Inhalable Particulate Environmental Robotic (PIPER Mk IV) has been developed over the last 5 years to provide a surrogate method to ascertain personal exposures to PM for children too young to have exposure measured by conventional personal sampling methodologies. PIPER provides a mobile autonomous platform on which to mount personal sampling devices. PIPER has been programmed to reproduce the pattern of a child's movement while at play on the floor, and as would a child disturbs and resuspends settled housedust. The PIPER Mk IV is the result of over 5 years of development and testing and has proven its reliability in tests in over 50 homes participating in an NIEHS funded (R01-ES014717) study. A validation study of an alternate personal sampling methodology using a robotic surrogate (PIPER) for young children's exposure to PM is proposed. The study will be carried out by mounting identical sampling systems on PIPER in side-by- side comparison with 100 children (50 boys and 50 girls) at play in their own homes. Children between >24 and 36 months of age will be recruited from participants of the existing PIPER Asthma Study and the pediatric practices participating in that study in central New Jersey. The goal of this validation study is to provide researchers with a new and novel tool for characterizing young children's exposure to environmental contaminants.

描述（由申请人提供）：研究提议验证机器人替代物 - 前吸入的颗粒物环境机器人（Piper）采样器 - 用于在研究人群中收集个人颗粒物（PM）的个人暴露，该研究人群太年轻，无法通过现有方法准确地收集个人暴露。暴露和剂量估计对于理解环保儿童疾病的病因至关重要。重悬PM的行为表明，在家庭中进行的固定区域测量可能会低估幼儿中的这些暴露。另外，PM暴露的峰值水平对于理解诸如哮喘等幼儿疾病的起源可能很重要。不幸的是，采样设备的大小和重量限制或排除其用于PM直接测量很小的孩子（例如婴儿和幼儿）（年龄在> 6至36个月）中的暴露量。在过去的五年中，已经开发了可吸入的颗粒物环境机器人（Piper MK IV），以提供一种替代方法，以确定对PM的个人暴露，以使太PM的儿童对太年轻，无法通过常规的个人抽样方法来衡量暴露。 Piper提供了一个移动自主平台，可以在该平台上安装个人抽样设备。派珀（Piper）已被编程为在地板上发挥作用时重现孩子运动的模式，而孩子会扰乱和重悬于Housedust的情况下。 Piper MK IV是超过5年的开发和测试的结果，并证明了其在参加NIEHS资助的NIEHS（R01-ES014717）研究的50多个房屋中的可靠性。提出了对使用机器人替代物（Piper）对幼儿接触PM的替代个人抽样方法的验证研究。这项研究将通过与100名儿童（50名男孩和50个女孩）在自己家中的比赛中进行比较，在Piper上安装相同的采样系统来进行。将从现有的Piper哮喘研究的参与者和参加新泽西州中部研究的儿科实践的参与者中招募> 24至36个月大的儿童。这项验证研究的目的是为研究人员提供一种新的新型工具，以表征幼儿接触环境污染物的暴露。