Regulation of Melanocyte Development and Differentiation

黑素细胞发育和分化的调节

• 批准号: 8552705
• 负责人: thomas j hornyak
• 金额: $ 4.64万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8552705
• 关键词: Cutaneous; Development; Disease; Ear; Exhibits; Functional disorder; Goals; Hearing; Hereditary Disease; Human; Individual; Inherited; Lead; Life; Melanoma Cell; Mus; Phenotype; Pigmentation physiologic function; Pigments; Regulation; Research; Syndrome; Tietze' s Syndrome; Waardenburg syndrome; Work; base; deafness; insight; melanocyte; mouse model; prevent

This project remains active principally to complete work describing melanocyte development and survival in a mouse model of the human deafness-pigmentation syndrome Waardenburg syndrome. In this study, the otic phenotype of this mouse model was studied. These mice exhibit a hearing deficit due to loss of melanocytes in the ear during the first several days of post-natal life. These results help to explain an important disparity between the severe otic pigmentary phenotype and the relatively mild cutaneous pigmentary phenotypes observed in individuals with the inherited developmental pigmentary disorders Waardenburg syndrome and Tietz syndrome. This work is currently under review at Pigment Cell & Melanoma Research.

该项目主要是在人类聋哑综合征Waardenburg综合征中的小鼠模型中完成描述黑素细胞发育和生存的工作。在这项研究中，研究了该小鼠模型的耳型。这些小鼠在产后生命的头几天内由于耳朵中的黑素细胞丧失而表现出听力不足。这些结果有助于解释严重的耳色素表型与在遗传性发育色素疾病的个体Waardenburg综合征和Tietz综合征中观察到的相对轻度皮肤色素表型之间的重要差异。目前，这项工作正在颜料细胞和黑色素瘤研究中进行综述。

项目成果

EZH2-dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression.

• DOI: 10.1158/1541-7786.mcr-10-0511
• 发表时间: 2011-04
• 期刊: Molecular cancer research : MCR
• 作者: Fan T;Jiang S;Chung N;Alikhan A;Ni C;Lee CC;Hornyak TJ
• 通讯作者: Hornyak TJ