Dermatoscopy in the Evaluation of Pigmented Lesions

皮肤镜检查在色素病变评估中的应用

• 批准号: 8349125
• 负责人: thomas j hornyak
• 金额: $ 6.55万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8349125
• 关键词: Affect; Benign; Biopsy; Cells; Characteristics; Clinic; Clinical; Clinical Protocols; Clinical Research; Collaborations; Cutaneous Melanoma; DNA Repair; Dermatology; Dermoscopy; Development; Devices; Doctor of Medicine; Doctor of Philosophy; Epigenetic Process; Evaluation; Family member; General Population; Goals; Hereditary Disease; Image; Incidence; Individual; Laboratories; Lesion; Malignant - descriptor; Melanocytic nevus; Microscopy; Mole the mammal; Patients; Pigments; Principal Investigator; Protocols documentation; Recruitment Activity; Skin; Skin Cancer; Structure; Techniques; Time; Tissues; United States National Institutes of Health; Visual; Work; Xeroderma Pigmentosum; digital; melanoma; novel; skin lesion

The scope of this project is limited to describing visual characteristics corresponding to various types of pigmented lesions in common, acquired melanocytic nevi and in patients with the rare genetic disease xeroderma pigmentosum. Under the auspices of clinical protocol 06-C-0060 (Thomas J. Hornyak, M.D., Ph.D., Principal Investigator), patients are recruited to the Dermatology Clinic for study and tissue acquisition of melanocytic nevi. Selected lesions are imaged with digital epiluminescent microscopy using a device, the digital dermatoscope, that permits evaluation of these lesions under illuminated magnification. Certain structures correlated with benign or malignant pigmented lesions can be observed with this technique. We collect images of lesions over time and analyze them for changes and for the presence of novel structures that can be correlated with specific types or arrangements of cells histopathologically. Also, in collaboration with Drs. Kenneth Kraemer and John DiGiovanna of the Dermatology Branch, we have obtained digital dermatoscopic images of biopsied pigmented skin lesions on approximately 20 patients with xeroderma pigmentosum. These patients have been seen at the NIH Clinical Center under the auspices of Dr. Kraemer's clinical protocol focused upon xeroderma pigmentosum. Currently the greater than twenty lesions whose information has been obtained from these patients are being analyzed, using standard dermatoscopic criteria, for features that may permit whether they can be classified clinically as malignant or benign. In addition, dermatoscopic evaluation of selected pigmented lesions on family members of those affected with xeroderma pigmentosum is sometimes performed.

该项目的范围仅限于描述与各种类型的色素性病变相对应的视觉特征，而在罕见的遗传病静脉疾病的患者中。 在临床方案06-C-0060的主持下（Thomas J. Hornyak，M.D。，Ph.D.，首席研究员），将患者招募到皮肤病学诊所进行研究和组织摄取黑素细胞NEVI。使用设备数字皮肤镜使用数字发光显微镜成像所选的病变，可在照明放大倍率下评估这些病变。通过这种技术，可以观察到与良性或恶性色素病变相关的某些结构。我们会随着时间的推移收集病变的图像，并分析它们是否与特定类型或组织病理学的特定类型或排列相关的新结构。 另外，与Drs合作。皮肤病学分支的Kenneth Kraemer和John Digiovanna，我们在大约20名患有静脉皮肤质的大约20例患者上获得了活检色素皮肤病变的数字皮肤镜图像。这些患者在Kraemer博士的临床方案的主持下在NIH临床中心看到了这些患者。目前，使用标准皮肤镜标准，正在分析从这些患者获得的信息的二十多个病变，这些病变可能允许它们是否可以在临床上被分类为恶性或良性。此外，有时还会对受心脏病患者的家庭成员的某些色素病变进行皮肤镜评估，有时会进行。