CT Image Estimation for Calculation of Delivered Dose

用于计算输送剂量的 CT 图像估计

• 批准号: 8338894
• 负责人: EDWARD L. CHANEY
• 金额: $ 43.68万
• 依托单位: MORPHORMICS, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8338894
• 关键词: Affect; Clinical; Code; Communication; Data; Development; Devices; Dose; Electronics; Elements; Goals; Image; Imaging Device; Implant; Light; Malignant neoplasm of prostate; Maps; Measures; Methods; Modeling; Normal tissue morphology; Organ; Output; Patients; Phase; Positioning Attribute; Property; Prostate; Public Health; Radiation; Radiation therapy; Records; Safety; Sampling; Series; Shapes; Speed; System; Technology; Tissues; Work; base; design; maltreatment; novel strategies; phase 1 study; phase 2 study; prevent; prototype; quality assurance; reconstruction; software development; treatment duration; treatment planning

DESCRIPTION (provided by applicant): The prostate is a mobile organ that demonstrates momentary and daily changes in position and shape that critically affect accurate delivery of radiation therapy. For this reason, in modern technically demanding radiation therapy for prostate cancer, it is standard practice to localize the prostate on most days treatment as an aid to achieve the goal of delivering a high dose to the prostate while protecting nearby radiosensitive normal tissues. The Phase I study established the feasibility of a novel approach that uses unique mathematical properties of a class of statistically trainable deformable shape models to estimate treatment image data by mapping reference CT image data into the treatment space based on measured positions of markers implanted in the prostate. The estimated images capture the pose, position and shape of the prostate during treatment and are suitable for accurate calculation of dose delivered to the prostate and immediately surrounding tissues. The first two years of this Phase II study will focus on design and development of a clinical prototype system based on this creative technology. The prototype will be evaluated in the clinical setting during the third year. The envisioned commercial form will accept input data from multiple devices including the treatment planning system, treatment machine, and marker tracking system, and will communicate output data to the treatment planning system. Within a few seconds the proposed prototype will use input data to automatically compute the estimated treatment image and calculate delivered dose. The proposed system will leverage work accomplished under a currently active Phase II project (R44 CA119571) that will allow the prototype to be used with intra-treatment imaging devices as well as marker-trackers. Moreover the proposed approach may enable a form of dose computation, called synchronized dynamic dose reconstruction, needed for the most accurate form of ART.

描述（由申请人提供）：前列腺是一种移动器官，显示出瞬间和每日的位置和形状变化，严重影响准确的放射治疗疗法。因此，在现代技术要求对前列腺癌的辐射疗法中，在大多数天治疗中将前列腺定位是标准做法，以帮助实现向前列腺高剂量提供高剂量的同时，同时保护附近的放射敏感正常组织。第一阶段的研究确定了一种新型方法的可行性，该方法使用一类可统计上可训练的可变形形状模型的独特数学特性来估算治疗图像数据，通过将参考CT图像数据映射到基于前列腺中植入的标记的测量位置中的治疗空间中。估计的图像捕获了治疗过程中前列腺的姿势，位置和形状，并且适合准确计算递送到前列腺和周围组织的剂量。这项II阶段研究的前两年将重点介绍基于这项创意技术的临床原型系统的设计和开发。该原型将在第三年在临床环境中进行评估。设想的商业形式将接受来自多个设备的输入数据，包括治疗计划系统，处理机和标记跟踪系统，并将输出数据传达给治疗计划系统。在几秒钟内，提出的原型将使用输入数据自动计算估计的治疗图像并计算递送的剂量。所提出的系统将利用当前有效的II期项目（R44 CA119571）完成的工作，该项目将允许原型与处理内成像设备以及标记轨迹器一起使用。此外，提出的方法可以实现一种剂量计算的形式，称为最准确的艺术形式所需的剂量计算，称为同步动态剂量重建。