COBRE: U KS: CORE A: ADMINISTRATION

COBRE：英国：核心 A：行政

• 批准号: 7720666
• 负责人: ROBERT P HANZLIK
• 金额: $ 40.27万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-15 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720666
• 关键词: Address; Area; Arts; Biological; Biology; Cell Differentiation process; Cellular biology; Centers of Research Excellence; Chemicals; Cities; Computer Retrieval of Information on Scientific Projects Database; Crystallography; Environment; Faculty; Funding; Goals; Grant; Institution; Interdisciplinary Study; Kansas; Mass Spectrum Analysis; Medical center; Mentors; Participant; Pathogenesis; Property; Protein Chemistry; Proteins; Proteomics; Range; Regulation; Research; Research Infrastructure; Research Personnel; Resources; Role; Source; Structure; Support of Research; Technology; United States National Institutes of Health; Universities; Wichita; Work; base; desire; instrumentation; interest; member; microbial; multidisciplinary; programs; protein structure function

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of the proposed COBRE program is to establish a multidisciplinary research center focused on the use of the best experimental strategies available to probe the structural and functional properties of targeted proteins. The Center will provide intensive mentoring and superb research environments to enhance the competitiveness of several junior faculty working at the interface of protein chemistry and biology at University of Kansas in Lawrence (KU-L), University of Kansas Medical Center in Kansas City (KUMC), Kansas State University in Manhattan (KSU), and Wichita State University in Wichita (WSU). Participating faculty are based in a variety of departments, but they all share a strong interest in understanding the relationship between the structure of a specific protein and its functional role in the biology of the cell. The expertise represented by both the junior faculty participants and the senior mentoring faculty spans a broad range from mass spectrometry and protein crystallography to microbial pathogenesis and regulation of cell differentiation. However, all participants are united by a strong desire to apply effective modern technologies and experimental strategies to the characterization of important proteins. Our specific aims are: Aim 1. To establish a Center of Biomedical Research Excellence in Protein Structure and Function that will synergize with other regional efforts in proteomics and protein chemistry and biology. Aim 2. To organize a core of well-established, NIH-funded faculty members across the four institutions who will serve as mentors for recently hired and to-be-hired faculty in the area of protein structure and function, and to support 5  6 independent research programs of junior faculty addressing significant problems in protein structure and function from a biological as well as chemical perspective in an integrated, multidisciplinary way. Over the 5-year period the COBRE program will assist at least 15 new faculty in developing highly competitive research programs in protein structure and function. Aim 3. To enhance the overall infrastructure for state-of-the-art research in protein structure and function through establishment of scientific cores that provides expertise and instrumentation in support of research in protein structure and function.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 拟议的 COBRE 计划的总体目标是建立一个多学科研究中心，专注于使用现有的最佳实验策略来探测目标蛋白质的结构和功能特性。该中心将提供密集的指导和一流的研究环境，以提高堪萨斯大学劳伦斯分校 (KU-L) 和堪萨斯城堪萨斯大学医学中心 (KUMC) 在蛋白质化学和生物学领域工作的几位初级教师的竞争力、位于曼哈顿的堪萨斯州立大学 (KSU) 和位于威奇托的威奇托州立大学 (WSU)。参与的教师来自各个院系，但他们都对了解特定蛋白质的结构与其在细胞生物学中的功能作用之间的关系抱有浓厚的兴趣。初级教师参与者和高级指导教师所代表的专业知识涵盖从质谱和蛋白质晶体学到微生物发病机制和细胞分化调节的广泛领域。然而，所有参与者都强烈渴望应用有效的现代技术和实验策略来表征重要蛋白质。我们的具体目标是： 目标 1. 建立蛋白质结构和功能生物医学卓越研究中心，该中心将与蛋白质组学、蛋白质化学和生物学方面的其他区域工作产生协同作用。 目标 2. 在四个机构中组织一支由 NIH 资助的、实力雄厚的核心教员，他们将担任蛋白质结构和功能领域最近聘用和即将聘用的教员的导师，并支持 5初级教师的 6 个独立研究项目，以综合、多学科的方式从生物学和化学角度解决蛋白质结构和功能的重大问题。在 5 年期间，COBRE 计划将协助至少 15 名新教师开发蛋白质结构和功能方面极具竞争力的研究项目。 目标 3. 通过建立提供专业知识和仪器支持蛋白质结构和功能研究的科学核心，加强蛋白质结构和功能最先进研究的整体基础设施。