COBRE: U KS: CORE A: ADMINISTRATION

COBRE：英国：核心 A：行政

• 批准号: 7381950
• 负责人: ROBERT P HANZLIK
• 金额: $ 42.09万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381950
• 关键词: COBRE; KS; CORE; ADMINISTRATION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of the proposed COBRE program is to establish a multidisciplinary research center focused on the use of the best experimental strategies available to probe the structural and functional properties of targeted proteins. The Center will provide intensive mentoring and superb research environments to enhance the competitiveness of several junior faculty working at the interface of protein chemistry and biology at University of Kansas in Lawrence (KU-L), University of Kansas Medical Center in Kansas City (KUMC), Kansas State University in Manhattan (KSU), and Wichita State University in Wichita (WSU). Participating faculty are based in a variety of departments, but they all share a strong interest in understanding the relationship between the structure of a specific protein and its functional role in the biology of the cell. The expertise represented by both the junior faculty participants and the senior mentoring faculty spans a broad range from mass spectrometry and protein crystallography to microbial pathogenesis and regulation of cell differentiation. However, all participants are united by a strong desire to apply effective modern technologies and experimental strategies to the characterization of important proteins. Our specific aims are: Aim 1. To establish a Center of Biomedical Research Excellence in Protein Structure and Function that will synergize with other regional efforts in proteomics and protein chemistry and biology. Aim 2. To organize a core of well-established, NIH-funded faculty members across the four institutions who will serve as mentors for recently hired and to-be-hired faculty in the area of protein structure and function, and to support 5 ¿ 6 independent research programs of junior faculty addressing significant problems in protein structure and function from a biological as well as chemical perspective in an integrated, multidisciplinary way. Over the 5-year period the COBRE program will assist at least 15 new faculty in developing highly competitive research programs in protein structure and function. Aim 3. To enhance the overall infrastructure for state-of-the-art research in protein structure and function through establishment of scientific cores that provides expertise and instrumentation in support of research in protein structure and function.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一，该子项目和研究者 (PI) 可能已从其他 NIH 来源获得主要资助，因此可以在其他 CRISP 机构中得到体现。列出的是该中心，不一定是研究者的机构。拟议的 COBRE 计划的总体目标是建立一个多学科研究中心，专注于使用现有的最佳实验策略来探索目标的结构和功能特性。该中心将。为堪萨斯大学劳伦斯分校 (KU-L)、堪萨斯州堪萨斯城堪萨斯大学医学中心 (KUMC) 提供密集的指导和一流的研究环境，以提高在蛋白质化学和生物学领域工作的几位初级教师的竞争力曼哈顿大学 (KSU) 和威奇托州立大学 (WSU) 的参与教师来自各个院系，但他们都对了解特定蛋白质的结构与其功能作用之间的关系抱有浓厚的兴趣。细胞生物学。初级教师参与者和高级指导教师所代表的专业知识涵盖从质谱和蛋白质晶体学到微生物发病机制和细胞分化调节的广泛领域。然而，所有参与者都强烈渴望应用有效的现代技术和实验。我们的具体目标是： 目标 1. 建立蛋白质结构和功能卓越生物医学研究中心，与蛋白质组学、蛋白质化学和生物学方面的其他区域工作协同作用。在四个机构中组织一支由 NIH 资助的、实力雄厚的核心教员，他们将担任蛋白质结构和功能领域最近聘用和即将聘用的教员的导师，并支持 5 ¿ 6 个初级教师独立研究项目，以综合、多学科的方式从生物学和化学角度解决蛋白质结构和功能的重大问题。在 5 年期间，COBRE 项目将帮助至少 15 名新教师培养高度竞争力。目标 3. 通过建立科学核心来增强蛋白质结构和功能最先进研究的整体基础设施，为蛋白质结构和功能研究提供专业知识和仪器。