3D Real-time imaging system for Subglottic Stenosis and Edema in Neonates

新生儿声门下狭窄和水肿的 3D 实时成像系统

基本信息

批准号：
8253516
负责人：
Tirunelveli Ramalingam
金额：
$ 32.3万
依托单位：
OCT MEDICAL IMAGING, INC.
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-03-15 至 2014-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8253516
关键词：
Anatomy Asia Bronchoscopy Businesses Cardiac Catheters Child Cicatrix Clinical Clinical Trials Critical Illness Custom Development Diagnosis Diagnostic Diagnostic Imaging Disease Edema Endoscopes Endoscopic Surgical Procedures Epithelial Epithelium Evaluation Event Excision Fiber Gold Histologic Histopathology Hypoxia Image Infant Inflammation Injury Intratracheal Intubation Laryngoscopy Larynx Lead Legal patent Licensing Life Light Lung Magnetic Resonance Imaging Marketing Medical Medical Device Medical Imaging Modeling Monitor Nature Neonatal Newborn Infant Operative Surgical Procedures Optical Coherence Tomography Optics Oryctolagus cuniculus Patients Physiological Pilot Projects Population Premature Infant Property Real-Time Systems Research Personnel Resolution Respiratory distress Sales Side Site Stenosis Stress Subglottis structure Surface System Techniques Technology Testing Time Tissues Tracheostomy procedure Tracheotomy procedure Trauma Tube Ultrasonography United States National Institutes of Health Work base cost effective critically ill newborn endotracheal experience flexibility imaging modality neonate nitinol success touchscreen

项目摘要

DESCRIPTION (provided by applicant): Major common cause of subglotis is endotracheal intubation during the critical first days of life. In the premature infant and newborn patient, thi condition may pass undetected or present as a life-threatening and, at worst, a life-ending event. Further, the tissues of the subglottis are delicate in nature, easily damaged, and rapidly develop edematous changes. These circumstances, when taken together, significantly predispose the subglottis to inflammation, scar formation, and stenosis in the critically ill newborn requiring endotracheal intubation. In the premature infant and newborn patient, this condition may pass undetected or present as a life-threatening and, at worst, a life-ending event. Using several licensed patents, OCT Medical Imaging Inc (OCTMI) proposes to develop an advanced ultrafast compact, cost-effective, touch-screen real-time 3D-functional Fourier domain functional OCT (F- OCT) system. We also develop a Nitionl based fiber microprobes (<0.6mm) that can be slipped into an endoscope or through an endotracheal tube. With this imaging system and probes, we will not only acquire images at near histopathological resolution, but also provide clinically important structural & functional information on the onset and progression of subglottic airway disease in these critically ill patients. PUBLIC HEALTH RELEVANCE: Major common cause of subglotis is endotracheal intubation during the critical first days of life. In the premature infant and newborn patient, this condition may pass undetected or present as a life-threatening and, at worst, a life-ending event. Further, the tissues of the subglottis are delicate in nature, easily damaged, and rapidly develop edematous changes. These circumstances, when taken together, significantly predispose the subglottis to inflammation, scar formation, and stenosis in the critically ill newborn requiring endotracheal intubation. In the premature infant and newborn patient, this condition may pass undetected or present as a life-threatening and, at worst, a life-ending event. Using several licensed patents, OCT Medical Imaging Inc (OCTMI) proposes to develop an advanced ultrafast compact, cost-effective, touch-screen real-time 3D-functional Fourier domain functional OCT (F- OCT) system. We also develop a Nitionl based fiber microprobes (<0.6mm) that can be slipped into an endoscope or through an endotracheal tube. With this imaging system and probes, we will not only acquire images at near histopathological resolution, but also provide clinically important structural & functional information on the onset and progression of subglottic airway disease in these critically ill patients.

描述（由申请人提供）：声门下的主要常见原因是生命关键第一天的气管插管。对于早产儿和新生儿患者，这种情况可能不会被发现，或者表现为危及生命，最坏的情况是导致生命终结。此外，声门下组织性质脆弱，容易受损，并迅速发生水肿性改变。这些情况综合起来，对于需要气管插管的危重新生儿来说，声门下明显容易发生炎症、疤痕形成和狭窄。对于早产儿和新生儿患者，这种情况可能不会被发现，或者表现为危及生命，最坏的情况是导致生命终结。 OCT Medical Imaging Inc (OCTMI) 利用多项许可专利，提议开发一种先进的超快紧凑型、经济高效的触摸屏实时 3D 功能傅里叶域功能 OCT (F-OCT) 系统。我们还开发了一种基于 Nitionl 的纤维微探针（<0.6mm），可以滑入内窥镜或通过气管内插管。借助该成像系统和探头，我们不仅可以获得接近组织病理学分辨率的图像，而且还可以提供有关这些危重患者声门下气道疾病的发病和进展的临床重要的结构和功能信息。公共卫生相关性：声门下的主要常见原因是在生命的关键第一天进行气管插管。在早产儿和新生儿患者中，这种情况可能会未被发现或表现为危及生命的事件，最坏的情况下，会导致生命终结。此外，声门下组织性质脆弱，容易受损，并迅速发生水肿性改变。这些情况综合起来，对于需要气管插管的危重新生儿来说，声门下明显容易发生炎症、疤痕形成和狭窄。对于早产儿和新生儿患者，这种情况可能不会被发现，或者会危及生命，最坏的情况下会导致生命终结。 OCT Medical Imaging Inc (OCTMI) 利用多项许可专利，提议开发一种先进的超快紧凑型、经济高效的触摸屏实时 3D 功能傅里叶域功能 OCT (F-OCT) 系统。我们还开发了一种基于 Nitionl 的纤维微探针（<0.6mm），可以滑入内窥镜或通过气管内插管。借助该成像系统和探头，我们不仅可以获得接近组织病理学分辨率的图像，而且还可以提供有关这些危重患者声门下气道疾病的发病和进展的临床重要的结构和功能信息。