Office based real-time high speed 3D-OCT system for diagnosis of early laryngeal
基于办公室的早期喉癌实时高速3D-OCT诊断系统
基本信息
- 批准号:8692703
- 负责人:
- 金额:$ 99.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-04-01 至 2018-02-28
- 项目状态:已结题
- 来源:
- 关键词:AddressAnimalsAppearanceAreaAsiaAutomationBenignBerylliumBiomedical EngineeringBiopsyCaliforniaClinicalClinical InvestigatorClinical ResearchClinical TrialsContractsCoughingDetectionDevelopmentDiagnosisDiagnosticDiseaseDisease ProgressionDysphoniaEarly DiagnosisEndoscopesEndoscopic Surgical ProceduresEndoscopyEngineeringEnsureEnvironmentEpithelialFamilyFiber OpticsFundingFutureGeneral AnesthesiaGoalsHandHead and Neck CancerHead and neck structureHoarsenessHousingHumanImageImage AnalysisImageryImaging technologyLaboratoriesLarynxLasersLeadLegal patentLengthLesionLettersLicensingLightMalignant - descriptorMalignant NeoplasmsMalignant neoplasm of larynxManualsMarketingMedical DeviceMedical ImagingMicroanatomyMicrosurgeryModelingModificationMonitorMorbidity - disease rateMorphologic artifactsMotionNoseOperative Surgical ProceduresOptical Coherence TomographyOpticsOtolaryngologistOutcomePainPatientsPenetrationPennsylvaniaPharyngeal structurePhasePhysical ExaminationPilot ProjectsPositioning AttributePremalignantProbabilityProblem SolvingProceduresRadiology SpecialtyReportingResearchResearch PersonnelResolutionSalesScanningScreening for cancerSedation procedureSensitivity and SpecificitySideSolid NeoplasmSourceSpeedStructureSurfaceSymptomsSystemSystems DevelopmentTechnologyTestingThree-Dimensional ImagingTimeTissuesTremorUnited States National Institutes of HealthUniversitiesVisualWorkabstractingbasecancer diagnosiscancer sitecancer therapyclinical applicationclinically relevantcommercializationcostcost effectivedesignflexibilityhigh riskhuman studyimaging modalityimprovedin vivolarynx Carcinomamillimetermortalityoptical imagingpoint of careprogramspublic health relevanceresponsescreeningsoftware developmenttwo-dimensionalvocal cord
项目摘要
DESCRIPTION (provided by applicant): Laryngeal carcinoma is the most common primary head and neck malignancy. Flexible fiber-optic or rigid endoscopes are normally inserted through the nose or into the pharynx for conventional physical examinations, but endoscopy alone cannot be used to differentiate between benign, pre-malignant and early malignant lesions, which are characterized by identical symptoms such as throat pain, coughing, or hoarseness, and nearly identical physical appearance. Both conventional examination and endoscopy lack the ability to visualize the depth of penetration of disease into the deeper layers
of the tissue, and provide information on vocal fold epithelial structure. Therefore, laryngeal cancer diagnosis has to rely on biopsies, which requires general anesthesia and surgical endoscopy. Multiple and repeated biopsies are common in order to increase diagnostic yield, and with this increasing morbidity form surgery. Regardless of the toll exacted on patients and their families, there are major costs associated with surgery, and significant patient time away from work. Hence, there is a huge need to develop a fast, mobile and noninvasive technology to aid in the early detection and monitoring of laryngeal malignant lesions, assist in selecting patients to undergo surgical biopsy. The use of OCT in managing early laryngeal epithelial cancer will be analogous to the use of macroscopic imaging modalities (i.e., MR, CT) in managing large solid tumors in the body. Using several licensed patents, OCT Medical Imaging Inc. (OCTMI) proposes to address the treatment and diagnosis of early laryngeal cancer using light based fiber optic imaging technology known as optical Coherence tomography (OCT), which produces a cross- sectional images at near histopathological resolution(Fujimoto et.al 2000). The first in vivo endoscopic OCT images in animals and humans were reported in 1997 (Tearney et.al., 1997)). Many clinical applications require a large area or 3-D imaging, which is
difficult to achieve with the Time Domain (TD) OCT. Hence, OCTMI proposes to use advanced Fourier domain (FD) OCT technology which provides 3D imaging at high speed and sensitivity ( Leitgeb et.al., 2003). Second, the paradigm shift from OR based to office-based imaging is necessary to make OCT a useful technology for head and neck cancer screening, early detection, and monitoring of disease progression. Incorporating this technology, OCTMI proposes to develop an advanced compact, cost-effective office based real-time 3D-functional Fourier domain functional OCT system that will not only acquire images at near histopathological resolution, but also will provide clinically important structural information on
suspect lesions, potential biopsy sites, and cancer margins of larynx in the office without the need for general anesthesia or sedation. OCTMI is well positioned to develop this technology since its founders and collaborators have developed several office-based real-time 3D-OCT systems and were first to conduct large scale clinical trials on laryngeal cancer to the best of our knowledge
描述(由申请人提供):喉癌是最常见的原发性头颈部恶性肿瘤。柔性光纤或硬性内窥镜通常通过鼻子或咽部插入进行常规体检,但单独使用内窥镜检查不能区分良性、恶变前期和早期恶性病变,这些病变的特征是相同的症状,例如喉咙疼痛、咳嗽或声音嘶哑,以及几乎相同的外貌。传统检查和内窥镜检查都缺乏可视化疾病渗透到更深层的深度的能力
组织的结构,并提供有关声带上皮结构的信息。因此,喉癌的诊断必须依靠活检,这需要全身麻醉和手术内窥镜检查。为了提高诊断率,多次和重复的活检很常见,手术的发病率也随之增加。 无论患者及其家人付出多少代价,手术都会产生巨大的费用,并且患者需要大量的休假时间。因此,迫切需要开发一种快速、移动、无创的技术来帮助早期发现和监测喉部恶性病变,协助选择患者进行手术活检。 使用 OCT 治疗早期喉上皮癌类似于使用宏观成像方式(即 MR、CT)治疗体内大型实体瘤。 OCT Medical Imaging Inc. (OCTMI) 利用多项许可专利,提议使用称为光学相干断层扫描 (OCT) 的光光纤成像技术来解决早期喉癌的治疗和诊断问题,该技术可在接近组织病理学的温度下生成横截面图像。分辨率(Fujimoto et.al 2000)。 1997 年报道了第一个动物和人类体内内窥镜 OCT 图像(Tearney 等人,1997)。 许多临床应用需要大面积或 3D 成像,这是
时域 (TD) OCT 很难实现。因此,OCTMI 提议使用先进的傅里叶域 (FD) OCT 技术,该技术可提供高速、高灵敏度的 3D 成像(Leitgeb 等,2003)。其次,从基于手术室的成像到基于办公室的成像的范式转变对于使 OCT 成为头颈癌筛查、早期检测和疾病进展监测的有用技术是必要的。结合这项技术,OCTMI 建议开发一种先进的紧凑型、经济高效的基于办公室的实时 3D 功能傅立叶域功能 OCT 系统,该系统不仅能够以接近组织病理学分辨率获取图像,而且还能够提供临床上重要的结构信息。
在办公室内检测可疑病变、潜在活检部位和喉癌边缘,无需全身麻醉或镇静。 OCTMI 处于开发这项技术的有利位置,因为其创始人和合作者已经开发了多个基于办公室的实时 3D-OCT 系统,并且据我们所知率先对喉癌进行了大规模临床试验
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Tirunelveli Ramalingam其他文献
Tirunelveli Ramalingam的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Tirunelveli Ramalingam', 18)}}的其他基金
Clinical evaluation and development of a diagnostic multi-modal intravascular imaging system
诊断性多模态血管内成像系统的临床评估和开发
- 批准号:
8976336 - 财政年份:2015
- 资助金额:
$ 99.35万 - 项目类别:
Office based real-time high speed 3D-OCT system for diagnosis of early laryngeal
基于办公室的早期喉癌实时高速3D-OCT诊断系统
- 批准号:
8525019 - 财政年份:2013
- 资助金额:
$ 99.35万 - 项目类别:
3D Real-time imaging system for Subglottic Stenosis and Edema in Neonates
新生儿声门下狭窄和水肿的 3D 实时成像系统
- 批准号:
8253516 - 财政年份:2012
- 资助金额:
$ 99.35万 - 项目类别:
3D Real-time imaging system for Subglottic Stenosis and Edema in Neonates
新生儿声门下狭窄和水肿的 3D 实时成像系统
- 批准号:
8441591 - 财政年份:2012
- 资助金额:
$ 99.35万 - 项目类别:
Office based Real-time high Speed 3-D OCT system for Diagnosis of EarlyLaryngeal
基于办公室的实时高速 3-D OCT 系统用于诊断早期喉癌
- 批准号:
7804402 - 财政年份:2010
- 资助金额:
$ 99.35万 - 项目类别:
Office based Real-time high Speed 3-D OCT system for Diagnosis of EarlyLaryngeal
基于办公室的实时高速 3-D OCT 系统用于诊断早期喉癌
- 批准号:
8053291 - 财政年份:2010
- 资助金额:
$ 99.35万 - 项目类别:
相似国自然基金
基于供应链视角的动物源性食品中抗微生物药物耐药性传导机制及监管策略研究
- 批准号:72303209
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
热带森林土壤氮添加下微节肢动物对氮转化过程的调控
- 批准号:32360323
- 批准年份:2023
- 资助金额:32 万元
- 项目类别:地区科学基金项目
Slc39a13在哺乳动物铁代谢中的作用
- 批准号:32371226
- 批准年份:2023
- 资助金额:50 万元
- 项目类别:面上项目
乳酸介导的组蛋白乳酸化调控哺乳动物主要合子基因组激活的机制研究
- 批准号:82301880
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
早期环境暴露对儿童哮喘免疫保护的动物实验和机制研究
- 批准号:82300031
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
相似海外基金
Investigating the roles of oncogenic extrachromosomal circular DNAs in cancer
研究致癌染色体外环状 DNA 在癌症中的作用
- 批准号:
10718423 - 财政年份:2023
- 资助金额:
$ 99.35万 - 项目类别:
Household Air Pollution, Adiposity, and Cardiorenal Disease Risk in Children
家庭空气污染、肥胖和儿童心肾疾病风险
- 批准号:
10739062 - 财政年份:2023
- 资助金额:
$ 99.35万 - 项目类别:
Impact of obesity on SARS-CoV-2 infection and reciprocal effects of SARS-CoV-2 on metabolic disease
肥胖对 SARS-COV-2 感染的影响以及 SARS-COV-2 对代谢疾病的相互影响
- 批准号:
10583175 - 财政年份:2023
- 资助金额:
$ 99.35万 - 项目类别:
Determining how Doublesex and sex-specific steroid hormone signaling control gonad development
确定双性和性别特异性类固醇激素信号如何控制性腺发育
- 批准号:
10679359 - 财政年份:2023
- 资助金额:
$ 99.35万 - 项目类别: