Office based Real-time high Speed 3-D OCT system for Diagnosis of EarlyLaryngeal

基于办公室的实时高速 3-D OCT 系统用于诊断早期喉癌

基本信息

批准号：
8053291
负责人：
Tirunelveli Ramalingam
金额：
$ 34.7万
依托单位：
OCT MEDICAL IMAGING, INC.
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-04-01 至 2013-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8053291
关键词：
3-Dimensional Abattoirs Address Animals Appearance Area Benign Biopsy California Clinical Clinical Trials Coughing Detection Development Diagnosis Diagnostic Disease Disease Progression Dysphonia Early Diagnosis Emerging Technologies Endoscopes Endoscopic Surgical Procedures Endoscopy Epithelial Family Family suidae Fiber Optics Focus Groups Funding General Anesthesia Goals Hand Head and Neck Cancer Head and neck structure Health Histology Hoarseness Human Image Imaging technology Laboratories Laryngoscopes Larynx Legal patent Lesion Licensing Light Malignant - descriptor Malignant Neoplasms Malignant neoplasm of larynx Marketing Medical Imaging Microanatomy Microsurgery Monitor Morbidity - disease rate Nose Operative Surgical Procedures Optical Coherence Tomography Otolaryngologist Outcome Pain Patients Penetration Pharyngeal structure Phase Physical Examination Positioning Attribute Premalignant Principal Investigator Probability Reporting Research Personnel Resolution Risk Sampling Scanning Screening procedure Secure Sedation procedure Site Solid Neoplasm Source Speed Staging Structure Symptoms System Systems Development Techniques Technology Testing Three-Dimensional Imaging Time Tissues Tremor Universities Work base cancer diagnosis cancer site clinical application cost cost effective flexibility imaging modality improved in vivo instrument instrumentation larynx Carcinoma mortality optical imaging programs public health relevance research clinical testing success two-dimensional user friendly software vibration vocal cord

项目摘要

Laryngeal carcinoma is the most common primary head and neck malignancy. Flexible fiber-optic or rigid endoscopes are normally inserted through the nose or into the pharynx for conventional physical examinations, but endoscopy alone cannot be used to differentiate between benign, pre-malignant and early malignant lesions, which are characterized by identical symptoms such as throat pain, coughing, or hoarseness, and nearly identical physical appearance. Both conventional examination and endoscopy lack the ability to visualize the depth of penetration of disease into the deeper layers of the tissue, and provide information on vocal fold epithelial structure. Therefore, laryngeal cancer diagnosis has to rely on biopsies, which requires general anesthesia and surgical endoscopy. Multiple and repeated biopsies are common in order to increase diagnostic yield, and with this increasing morbidity form surgery. Regardless of the toll exacted on patients and their families, there are major costs associated with surgery, and significant patient time away from work. Hence, there is a huge need to develop a fast, mobile and noninvasive technology to aid in the early detection and monitoring of laryngeal malignant lesions, assist in selecting patients to undergo surgical biopsy. The use of OCT in managing early laryngeal epithelial cancer will be analogous to the use of macroscopic imaging modalities (i.e., MR, CT) in managing large solid tumors in the body. Using several licensed patents, OCT Medical Imaging Inc (OCTMI) proposes to address the treatment and diagnosis of early laryngeal cancer using light based fiber optic imaging technology known as optical Coherence tomography (OCT), which produces a cross- sectional images at near histopathological resolution(Fujimoto et.al 2000). The first in vivo endoscopic OCT images in animals and humans were reported in 1997 (Tearney et.al., 1997)). Many clinical applications require a large area or 3-D imaging, which is difficult to achieve with the Time Domain (TD) OCT. Hence, OCTMI proposes to use advanced Fourier domain (FD) OCT technology which provides 3D imaging at high speed and sensitivity (Leitgeb et.al, 2003). Second, the paradigm shift from OR based to office-based imaging is necessary to make OCT a useful technology for head and neck cancer screening, early detection, and monitoring of disease progression. Incorporating this technology, OCTMI proposes to develop an advanced compact, cost-effective office based real-time 3D-functional Fourier domain functional OCT system that will not only acquire images at near histopathological resolution, but also will provide clinically important structural information on suspect lesions, potential biopsy sites, and cancer margins of larynx in the office without the need for general anesthesia or sedation. OCTMI is well positioned to develop this technology since its founders and collaborators have developed several office-based real-time 3D-OCT systems and were first to conduct large scale clinical trials on laryngeal cancer to the best of our knowledge.

喉癌是最常见的原发性头部，脖子恶性肿瘤。通常通过鼻子或进入常规身体检查的咽部，但仅内窥镜检查不能使用区分良性，恶性和早期恶性病变，其特征是相同的症状，例如喉咙痛，咳嗽或嘶哑，几乎相同的身体外貌。常规检查和内窥镜检查都无法可视化深度疾病渗透到组织的较深层中，并提供声带上的信息上皮结构。因此，喉癌诊断必须依靠活检，这需要全身麻醉和手术内窥镜检查。多次和重复的活检是常见的增加诊断产量，并随着这种发病率的增加手术。不管财产如何在患者及其家人身上，手术有重大成本，并且很大耐心的时间下班。因此，需要发展快速，移动和无创的巨大需求帮助早期检测和监测喉恶性病变的技术，协助选择患者接受手术活检。使用OCT来管理早期喉上皮癌的使用将类似于使用宏观成像方式（即MR，CT）在管理大型固体中体内的肿瘤。使用几项许可的专利，Oct Medical Imaging Inc（OCTMI）建议使用光基光纤成像来解决早期喉癌的治疗和诊断被称为光学相干断层扫描（OCT）的技术，该技术产生横截面图像在接近组织病理学分辨率（Fujimoto et.Al 2000）。体内的第一张内窥镜OCT图像 1997年报道了动物和人类（Tearney等，1997）。许多临床应用需要大面积或3-D成像，这很难实现时间域（TD）。因此，Octmi 建议使用高级傅立叶域（FD）OCT技术，该技术可在高处提供3D成像速度和灵敏度（Leitgeb et.al，2003）。其次，范式从基于办公室或基于办公室的转变成像是使OCT成为头颈癌筛查的有用技术，早期是必要的检测和监测疾病进展。结合了这项技术，Octmi建议开发一个基于高级的紧凑型，成本效益的实时3D功能傅立叶域功能性的OCT系统不仅将以接近组织病理学的分辨率获取图像，还将获取图像将提供有关可疑病变，潜在活检部位和办公室中喉的癌症边缘，无需全身麻醉或镇静。 Octmi是由于其创始人和合作者已经开发了几个基于办公室的实时3D-OCT系统，并首先在喉部进行大规模的临床试验据我们所知，癌症。