Maintenance and Improvement of NINDS Infrastructure

NINDS基础设施的维护和改进

• 批准号: 8557125
• 负责人: Alan Koretsky
• 金额: $ 751.98万
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8557125
• 关键词: Animals; Area; Cell Culture Techniques; Cerebrum; Chemistry; Clinical; Core Facility; Detection; Electrophysiology (science); Ensure; Equipment; Flow Cytometry; Fluorescence; Functional Imaging; Goals; Image; Institutes; Laboratories; Laboratory Research; Lasers; Lead; Light; Location; Magnetic Resonance Imaging; Maintenance; Microcirculation; Microscope; Microscopy; National Institute of Neurological Disorders and Stroke; Neurology; Neurosciences; Neurosciences Research; Operative Surgical Procedures; Phase; Photons; Physiologic pulse; Physiology; Research; Research Infrastructure; Research Support; Resources; Scientist; Spectrum Analysis; System; United States National Institutes of Health; Water; cost effective; detector; fluorescence microscope; molecular imaging; multi-photon; nervous system infection; protein aminoacid sequence

The following laboratories and research support areas underwent major renovations during FY 2012: Renovate Electrophysiology and imaging/microscopy laboratory for Dr. Kevin Briggman, Chief, Circuit Dynamics and Connectivity Unit. Location, NIH Bethesda Campus, Bldg 35 Renovate animal imaging and physiology laboratory space for Dr. Afonso Silva , Chief, Cerebral Microcirculation Unit. Location, NIH Bethesda Campus, Bldg 49 Renovate electrophysiology and cell culture laboratory for Dr. Wei Lu Silva, Chief, Cerebral Microcirculation Unit. Location, NIH Bethesda Campus, Bldg 35 Renovate chemistry laboratory for Dr. Avi Nath, Chief, Section of Infections of the Nervous Systems. Location, NIH Bethesda Campus, Bldg 10 Renovate microscopy and basic laboratory space for Dr. Afonso Silva , Chief, Cerebral Microcirculation Unit. Location, NIH Bethesda Campus, Bldg 49 Renovate basic laboratory for Dr. Russ Lonser, Chief, Surgical Neurology Branch, Location, NIH Bethesda Campus, Bldg 10 Relocation and activation activities for the Porter Neuroscience Research Center Phase 2, Mixed institute laboratory building, with NINDS has the lead institute. Location, NIH Bethesda Campus, Bldg 36 The following pieces of major shared equipment were purchased to support a large number of PIs: - Carl Zeiss LSM 780 34 Channel Spectral Detection system with GaAsP external detectors for Multi-photon and Single photon imaging for the Laboratory of Functional and Molecular Imaging - Upgrade existing Leica confocal microscope with pulsed white-light laser and capability for gated fluorescence detection for the Light Imaging Facility - 10-channel fluorescence microscope imaging system for the NINDS Flow Cytometry Core Facility - Orbitrap Elite 10000 with water recirculator for the Peptide Sequencing Facility - Infrastructure for server room for the Porter Neuroscience Research Center Phase 2, a mixed institute laboratory building, with NINDS has the lead institute - A Magnetic Resonance Imaging and Spectroscopy Console for a 17.6T Magnet for The Laboratory of Functional and Molecular Imaging

在2012财年期间，以下实验室和研究支持领域进行了重大翻新： 为电路动力学和连通性单元的负责人凯文·布里格曼（Kevin Briggman）博士的校准电生理学和成像/显微镜实验室。位置，NIH Bethesda校园，BLDG 35 为脑微循环单元酋长Afonso Silva博士翻新动物成像和生理实验室空间。位置，NIH Bethesda校园，BLDG 49 为脑微循环单元的负责人Wei Lu Silva博士翻新电生理学和细胞培养实验室。位置，NIH Bethesda校园，BLDG 35 为神经系统感染部分Avi Nath博士翻新化学实验室。位置，NIH Bethesda校园，BLDG 10 翻新显微镜和基本实验室空间，用于脑微循环单元的主管Afonso Silva博士。位置，NIH Bethesda校园，BLDG 49 翻新基本实验室为Russ Lonser博士，Russ Lonser博士，外科神经病学分支，位置，NIH Bethesda校园，BLDG 10 Ninds的搬运工神经科学研究中心第二阶段的搬迁和激活活动是主要研究所。位置，NIH Bethesda校园，大厦36 购买了以下主要共享设备以支持大量PI： -Carl Zeiss LSM 780 34通道光谱检测系统，具有GAASP外部检测器，用于多光子和单个光子成像，用于功能和分子成像实验室 - 升级使用脉冲的白色光激光器的现有Leica共聚焦显微镜以及光成像设施的门控荧光检测能力 - Ninds流式细胞仪核心设施的10通道荧光显微镜成像系统 - 用水再循环器进行肽测序设施的Orbitrap Elite 10000 - 搬运工神经科学研究中心2阶段的服务器室基础设施，与Ninds混合实验室大楼，有主要研究所 - 功能和分子成像实验室的磁共振成像和光谱控制台