Maintenance and Improvement of NINDS Infrastructure

NINDS基础设施的维护和改进

• 批准号: 9157600
• 负责人: Alan Koretsky
• 金额: $ 850.34万
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9157600
• 关键词: Animals; Area; Biophysics; Cellular biology; Chief Cell; Chlorine; Clinical; Dendrites; Development; Disease; Ensure; Equipment; Farming environment; Functional Magnetic Resonance Imaging; Goals; High Pressure Liquid Chromatography; Housing; Image; Immunology; Inherited; Institutes; Laboratories; Laboratory Research; Lead; Light Microscope; Location; Magnetic Resonance Imaging; Maintenance; Molecular; Morphogenesis; Myopathy; National Center for Complementary and Alternative Medicine; National Institute of Mental Health; National Institute of Neurological Disorders and Stroke; Neuropharmacology; Neurosciences; Neurosciences Research; Phase; Physiology; Positron-Emission Tomography; Proteomics; Recruitment Activity; Research; Research Infrastructure; Research Support; Resources; Scientist; Stroke; Synapses; System; United States National Institutes of Health; Viral; Water; Wing; Work; animal facility; cost effective; drinking; extracellular; intravital imaging; mass spectrometer; neural circuit; neurosurgery; protein aminoacid sequence; relating to nervous system; structural biology; synaptic function

NATIONAL INSTITUTES OF HEALTH NINDS Facilities Planning / Equipment Bldg 35, GF352-4 The following laboratories and research support areas underwent renovations during FY 2015: 1. Perform the lab renovation for Dr Kevin Briggman, Chief, Circuit Dynamics and Connectivity unit. Location, NIH Campus, Bldg 35. 2. Relocation and activation activities for the Porter Neuroscience Research Center Phase 2, Mixed institute laboratory building, with NINDS as the lead institute. Location, NIH Bethesda Campus, Bldg 35. 3. Perform a renovation to the freezer farm room located in the Porter Neuroscience Research Center that supports multiple ICs. Location, NIH Bethesda Campus, Bldg 35. 4. Perform a renovation to the Autoclaves in B-Wing that supports multiple PIs. Location, NIH Bethesda Campus, Bldg 49. 5. Complete the lab renovation and fit-out for Dr Quan Yuan, Chief, Dendrite Morphogenesis and Plasticity Unit. Location, NIH Bethesda Campus, Bldg 35. 6. Perform a lab renovation and fit-out for Dr Kenton Swartz, Chief, Molecular Physiology & Biophysics Section. Location, NIH Bethesda Campus, Bldg 35. 7. Relocation and activation activities for the F-Wing project, Mixed institute laboratory wing. Laboratory construction includes work for laboratories and offices for two PIs, Dr Dragan Maric Chief, FACS Facility and Dr Dorian McGavern, Chief, Viral Immunology and Intravital Imaging Section and one new NINDS PI recruit. Location, NIH Bethesda Campus, Bldg 10. 8. Complete the lab renovation and fit-out for Dr Lucy Forrest, Chief, Computational Structural Biology Unit. Location, NIH Bethesda Campus, Bldg 35. 9. Perform the lab renovation and fit-out for Dr Wei Lu, Chief, Synapse and Neural Ciruit Unit. Location, NIH Bethesda Campus, Bldg 35. 10. Perform the lab renovation and fit-out for Dr Craig Blackstone, Chief, Cell Biology Section. Location, NIH Bethesda Campus, Bldg 35. 11. Perform a lab renovation and fit-out for Dr David Sibley, Chief, Molecular Neuropharmacology Section. Location, NIH Bethesda Campus, Bldg 35. 12. Renovate the chlorine repressurization animal drinking system for the PNRC Shared Animal Facility. Location, NIH Bethesda Campus, Bldg 35. 13. Renovate the procurement and administrative offices. Location, NIH Bethesda Campus, Bldg 35. 14. Perform the lab renovation for Dr Ami Mankodi, Chief, Hereditary Muscle Diseases Unit. Location, NIH Bethesda Campus, Bldg 35. 15. Perform the renovation to the office for Dr Bibiana Bielekova, Chief, Neuroimmunological Diseases Unit. Location, NIH Bethesda Campus, Bldg 10. 16. Complete the lab renovation for Dr Alex Chesler, NCCAM, as part of a collaborative and shared space arrangement. Location, NIH Bethesda Campus, Bldg 35. 17. Perform a renovation to add two offices for Dr John Hallenbeck, Chief, Stroke Branch. Location, NIH Bethesda Campus, Bldg 10. 18. Perform a renovation to install a 17T MRI Magnet to support NINDS Intramural PIs. Location, NIH Bethesda Campus, Bldg 35. 19. Initiate a renovation plan for the 11.7T MRI Magnet facility that supports NIH Intramural PIs. Location, NIH Bethesda Campus, Bldg 10. 20. Perform a renovation to the laboratory space that houses Mass Spectrometers for Dr Joseph Steiner, Chief, Neurotherapeutic Development Unit. Location, NIH Bethesda Campus, Bldg 10. 21. Perform a renovation to the office suite for Laurie Arrants, Chief, NINDS Office for Tech Transfer. Location, NIH Bethesda Campus, Bldg 31. The following pieces of major shared equipment were purchased to support a large number of PIs: 1. Zeiss LSM 880 confocal microscope for the Light Imaging Facility, Synaptic Functions Section, and Synapse and Neural Circuit Unit. 2. Waters Breeze 2 HPLC System with Spectrophotometer for the Molecular Physiology & Biophysics Section 3. Q Exactive HF Standard Mass Spectrometer for the Clinical Proteomics Unit 4. Leica TCS SP8 Mass Spectrometer for the Viral Immunology & Intravital Imaging Unit 5. LC-MS system for sequencing for the Peptide Sequencing Facility 6. XFe96 Extracellular Flux Analyzer for the Clinical Neurosurgery Unit 7. 3T & 4T MRI scanner upgrades for the shared NIMH/NINDS fMRI Facility 8. PET CT upgrade for the Clinical Center

国立卫生研究院NINDS设施计划 /设备 BLDG 35，GF352-4 以下实验室和研究支持领域在2015财年进行了翻新： 1。对电路动力学和连接单元的负责人凯文·布里格曼（Kevin Briggman）博士进行实验室翻新。位置，NIH校园，BLDG 35。 2。搬运工神经科学研究中心第二阶段，混合研究所实验室建设的搬迁和激活活性，纳德斯为主要研究所。位置，NIH Bethesda校园，Bldg 35。 3.对位于波特神经科学研究中心的冰柜农用室进行翻新，该室支持多个IC。 位置，NIH Bethesda校园，Bldg 35。 4.对B翼的高压族进行翻新，以支持多个PI。 位置，NIH Bethesda校园，BLDG 49。 5。为树突形态发生和可塑性单位Quan Yuan博士Quan Yuan博士完成实验室翻新和装修。 位置，NIH Bethesda校园，Bldg 35。 6。为分子生理与生物物理学部分主管Kenton Swartz博士进行实验室翻新和装修。 位置，NIH Bethesda校园，Bldg 35。 7。混合研究所实验室机翼的F翼项目的搬迁和激活活动。实验室建设包括为两个PI的实验室和办公室的工作，Dragan Maric博士，FACS设施和Dorian McGavern博士，病毒免疫学和插入式成像部门的负责人Dorian McGavern博士以及一名新的NINDS PI Recruit。位置，NIH Bethesda校园，大厦10。 8。完成计算结构生物学单元的首席露西·福雷斯特（Lucy Forrest）博士的实验室翻新和装修。位置，NIH Bethesda校园，Bldg 35。 9。为魏卢（Wei Lu）博士，首席，突触和神经ciruit单位进行实验室翻新和装修。位置，NIH Bethesda校园，Bldg 35。 10。对Craig Blackstone博士进行实验室翻新和装修，酋长，细胞生物学部分。 位置，NIH Bethesda校园，Bldg 35。 11.分子神经药物学部分酋长David Sibley博士进行实验室翻新和装修。 位置，NIH Bethesda校园，Bldg 35。 12。对PNRC共享动物设施的氯抑制动物饮用系统进行翻新。 位置，NIH Bethesda校园，Bldg 35。 13。翻新采购和行政办公室。 位置，NIH Bethesda校园，Bldg 35。 14.对世袭肌肉疾病部门负责人阿米·曼科迪（Ami Mankodi）博士进行实验室翻新。 位置，NIH Bethesda校园，Bldg 35。 15.对神经免疫疾病部门负责人Bibiana Bielekova博士进行翻新。 位置，NIH Bethesda校园，大厦10。 16.作为协作和共享空间安排的一部分，为NCCAM的Alex Chesler博士完成实验室翻新。 位置，NIH Bethesda校园，Bldg 35。 17.进行翻新，为中风分支的酋长约翰·哈伦贝克博士添加两个办公室。 位置，NIH Bethesda校园，大厦10。 18.进行翻新以安装17T MRI磁铁以支持Ninds内壁内PI。 位置，NIH Bethesda校园，Bldg 35。 19。启动支持NIH壁内PIS的11.7T MRI磁铁设施的翻新计划。 位置，NIH Bethesda校园，大厦10。 20.对实验室空间进行翻新，该实验室容纳神经治疗开发单元的酋长约瑟夫·斯坦纳博士。 位置，NIH Bethesda校园，大厦10。 21.为劳里·阿兰特斯（Laurie Arrants），纳德斯（Ninds）技术转移办公室酋长劳里·阿兰特（Laurie Arrants）进行翻新。 位置，NIH Bethesda校园，大厦31。 购买了以下主要共享设备以支持大量PI： 1。Zeiss LSM 880光成像设施，突触功能部分以及突触和神经电路单元的共聚焦显微镜。 2。海水微风2 HPLC系统，分光光度计用于分子生理与生物物理学部分 3。Q精确HF标准质谱仪的临床蛋白质组学单元 4。用于病毒免疫学和插入式成像单元的Leica TCS SP8质谱仪 5。用于测序肽测序设施测序的LC-MS系统 6。XFE96临床神经外科手术单元的细胞外通量分析仪 7。3T和4T MRI扫描仪升级共享NIMH/NINDS fMRI设施 8。临床中心的PET CT升级